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University of Washington
School of Medicine
Box 358050
850 Republican Street
Brotman Building 453
Seattle, WA 98195-8050

Jay Heinecke, MD


Dr. Jay Heinecke

Metabolism, Endocrinology and Nutrition &emdash; Professor of Medicine

Research in the Heinecke laboratory focuses on the role of macrophages in the pathogenesis of atherosclerosis, diabetes and obesity. A central effort of the research group is the identification of mechanisms that mediate site-specific modification of proteins by activated phagocyte. There is also a strong interest in using tandem mass spectrometry to identify the shed and secreted proteome of macrophages.

The research group employs a variety of techniques, including mass spectrometry, high-performance liquid chromatography and high resolution nuclear magnetic resonance spectroscopy, to identify and quantify proteins and oxidized biomolecules. Genetically engineered mice are used to establish the physiological importance of oxidative stress and macrophages in atherosclerosis and obesity. Another major effort centers on the application of proteomics techniques to translational studies of human cardiovascular disease.