Professor Gail Jarvik M.D., Ph.D. received her Ph.D. at the University of Michigan and her M.D. at the University of Iowa in the Medical Scientist Training program. She completed residency in internal medicine at University of Pennsylvania and fellowship in medical genetics at the University of Washington. Dr. Jarvik holds the Arno G. Motulsky Endowed Chair in Medicine and heads the Division of Medical Genetics and the Northwest Institute of Genetic Medicine. Dr. Jarvik is interested in the genetic basis of complexly inherited genetic disease and has a long-standing interest in biomedical ethics.
Dr. Jarvik’s ongoing research focuses on four areas:
1. Application of high throughput sequencing to clinical medicine as part of the
CSER consortium and Center of Mendelian Genetics (CMG).
2. Genome-wide association study (GWAS) of phenotypes from clinical electronic medical records in the eMERGE consortium. This consortium includes over 25,000 subjects at 7 sites. Phenotypes of interest include white blood cell count and differential as well as carotid artery disease.
3. Genetic predictors of carotid artery disease. In addition to the eMERGE data, Dr. Jarvik uses densely genotyped and phenotyped case-control cohorts to study the genetic epidemiology of carotid artery disease. Oxidation and inflammation are areas of interest.
4. Exomic analysis of lipid disorders in large families. We are using a whole exome approach to identify rare, high penetrance mutations that influence lipid traits. Phenotypes include apolipoprotein B, HDL-C, and phospholipid transfer protein. Large families allow the phenotyping of multiple subjects sharing the same rare variants.
Dr. Jarvik also collaborates on GWAS studies of multiple phenotypes and exomic analyses of Mendelian disorders.