Michael Laflamme is an Assistant Professor in the Department of Pathology at the University of Washington. He completed the Medical Scientist (MD/PhD) Training Program at Emory University, where he examined the regulation of calcium homeostasis by b-adrenergic signaling in adult ventricular cardiomyocytes. Dr. Laflamme then completed his residency in Anatomic Pathology at the University of Washington Medical Center, where he also received subspecialty diagnostic training in cardiovascular pathology. During Dr. Laflamme's postdoctoral fellowship, also completed at the University of Washington, he conducted research on the role of exogenous and endogenous stem cells in myocardial repair.
His own laboratory's current focus is on exploring the regenerative potential
of cardiomyocytes derived from human pluripotent stem cells, including both embryonic
stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Our group is
particularly interested in better understanding their electrophysiological behavior,
both in vitro and in vivo. Toward this end, we have ongoing studies on the following
1) determining the mechanisms of excitation-contraction coupling in stem cell-derived cardiomyocytes and testing approaches to promote their functional maturation;
2) identifying and manipulating signaling pathways that regulate cardiac subtype “specialization” with the eventual goal of deriving purified populations of stem cell-derived nodal/pacemaker or ventricular myocytes;
3) testing novel strategies to promote the electromechanical integration of stem cell-derived cardiac implants in preclinical models of myocardial infarction; and
4) determining the electrocardiographic consequences of their transplantation.