Anush Oganesian is a Research Assistant Professor in the Department of Anesthesiology at the University of Washington. She received her BS/MS in Molecular Biology/Chemistry from the Yerevan University in Armenia and her PhD in Biochemistry/Organic Chemistry from the Institute of Element Organic Compounds, Academy of Sciences in Moscow, Russia. Anush did her post-doctorial training at the University of Washington with Linda Sandell in the Department of Orthopedics studying the extracellular matrix proteins including the N-propeptide of type IIA procollagen and its interaction with TGFß1 and BMP-2 proteins. She continued her postdoctoral training in the laboratory of Daniel Bowen-Pope in the Department of Pathology focusing on biochemical characterization, functional studies and signal transduction pathways regulated by PTPRQ and Phogrin, novel transmembrane protein tyrosine phosphatases with PTEN-like lipid-phosphatase activities.
Her Current Research is focused primarily on
1) Molecular pharmacology, signal transduction pathways and trafficking of human alpha1a-adrenergic receptors and the role of extracellular matrix proteins, such as MMPs (matrix metalloproteases) and ADAMs (a disintegrin and metalloproteinase) in G-protein-coupled receptor (GPCR) signaling in cardiomyocytes and smooth muscle cells;
2) Naturally occurring alpha1aAR SNPs associated with human diseases and elucidation of signaling pathways triggered by these genetic variants, cross-talks between mutant GPCRs and tyrosine kinases and phosphatases, cellular and molecular mechanisms implicated in pathogenesis of hypertension and cardiomyopathy;
3) Use of proteomics for identification of novel interacting partners for mutant and normal gene products and their role in disease etiology, development, and prevention.