{"id":105,"date":"2017-01-17T21:56:34","date_gmt":"2017-01-17T21:56:34","guid":{"rendered":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/?page_id=105"},"modified":"2021-07-20T15:29:37","modified_gmt":"2021-07-20T22:29:37","slug":"projects-maves-lab","status":"publish","type":"page","link":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/","title":{"rendered":"Projects"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><span style=\"text-decoration: underline;\">Investigating the Developmental Biology and Epigenetics of Muscular Dystrophy<\/span><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"220\" height=\"180\" src=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg\" alt=\"\" class=\"wp-image-334\" title=\"Early slow-twitch (red) and fast-twitch (green) muscle cells in a zebrafish embryo.\"\/><\/figure><\/div>\n\n\n\n<p>The Maves Lab is taking advantage of a zebrafish model of Duchenne muscular dystrophy (the <em>dmd<\/em> mutant strain) to investigate the developmental biology and epigenetics of DMD as well as to identify new drug therapies for DMD. We also work closely with Dr. David Mack\u2019s lab (<a href=\"https:\/\/iscrm.uw.edu\/faculty\/david-l-mack\/\">https:\/\/iscrm.uw.edu\/faculty\/david-l-mack\/<\/a>) to take advantage of human iPSC and rat models of DMD<\/p>\n\n\n\n<p><a href=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs\/maves-lab\/projects\/using-zebrafish-to-identify-drug-combination-therapies-and-biomarkers-for-duchenne-muscular-dystrophy\/\">Read more&#8230;<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator alignwide\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span style=\"text-decoration: underline;\">Pinpointing How Genes Influence Muscle Cell Differentiation<\/span><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"220\" height=\"180\" src=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/greenleaf.jpg\" alt=\"\" class=\"wp-image-335\" title=\"High-magnification image of muscle fibers in a zebrafish larva.\"\/><\/figure><\/div>\n\n\n\n<p>The Maves Lab is making key discoveries about how muscle cell differentiation is controlled. We are interested in understanding the transcriptional regulation of skeletal muscle fiber type differentiation (fast-twitch vs slow-twitch fibers).<\/p>\n\n\n\n<p><a href=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs\/maves-lab\/projects\/understanding-skeletal-muscle-fiber-type-differentiation\/\">Read more&#8230;<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span style=\"text-decoration: underline;\">CRISPR Editing and Screening for Novel Genes that Cause Heart Defects<\/span><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"225\" src=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2021\/01\/fishies-300x225-1.jpg\" alt=\"\" class=\"wp-image-2175\" title=\"The Maves lab uses zebrafish to study why certain muscle fibers are susceptible to muscular dystrophy.\"\/><\/figure><\/div>\n\n\n\n<p>The lab is using CRISPR genome editing to engineer mutations in zebrafish in genes that are associated with congenital heart defects in humans. The goal is to understand how mutations in these genes lead to heart developmental malformations. In particular, we are studying the roles of Pbx and Meis transcription factors in heart development. We are also using CRISPR genome screening in zebrafish to test the functions of new genes that have been implicated in human congenital heart defects. Recently our screening has identified several new genes required for heart development. Our goal is to gain insight into the complex genetics of congenital heart defects.\u00a0<\/p>\n\n\n\n<p> <a style=\"text-align: justify;\" href=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs\/maves-lab\/projects\/using-zebrafish-and-crispr-cas9-to-understand-the-mechanisms-of-heart-development-and-the-genetics-of-congenital-heart-defects\/\">Read more&#8230;<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigating the Developmental Biology and Epigenetics of Muscular Dystrophy The Maves Lab is taking advantage of a zebrafish model of Duchenne muscular dystrophy (the dmd mutant strain) to investigate the developmental biology and epigenetics of DMD as well as to identify new drug therapies for DMD. We also work closely with Dr. David Mack\u2019s lab &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Projects\" class=\"read-more button\" href=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#more-105\" aria-label=\"More on Projects\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":12,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":{"0":"post-105","1":"page","2":"type-page","3":"status-publish","5":"no-featured-image-padding"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Projects - Maves Lab<\/title>\n<meta name=\"description\" content=\"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projects - Maves Lab\" \/>\n<meta property=\"og:description\" content=\"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"Center for Developmental Biology and Regenerative Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-20T22:29:37+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website\",\"url\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/\",\"name\":\"Center for Developmental Biology and Regenerative Medicine\",\"description\":\"CDBRM\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg\",\"contentUrl\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg\",\"width\":220,\"height\":180},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#webpage\",\"url\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/\",\"name\":\"Projects - Maves Lab\",\"isPartOf\":{\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#primaryimage\"},\"datePublished\":\"2017-01-17T21:56:34+00:00\",\"dateModified\":\"2021-07-20T22:29:37+00:00\",\"description\":\"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.\",\"breadcrumb\":{\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"CDBRM Home\",\"item\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Labs\",\"item\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Maves Lab\",\"item\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Projects\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Projects - Maves Lab","description":"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/","og_locale":"en_US","og_type":"article","og_title":"Projects - Maves Lab","og_description":"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.","og_url":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/","og_site_name":"Center for Developmental Biology and Regenerative Medicine","article_modified_time":"2021-07-20T22:29:37+00:00","og_image":[{"url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg"}],"twitter_card":"summary","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebSite","@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website","url":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/","name":"Center for Developmental Biology and Regenerative Medicine","description":"CDBRM","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"ImageObject","@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#primaryimage","inLanguage":"en-US","url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg","contentUrl":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/muscle.jpg","width":220,"height":180},{"@type":"WebPage","@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#webpage","url":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/","name":"Projects - Maves Lab","isPartOf":{"@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website"},"primaryImageOfPage":{"@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#primaryimage"},"datePublished":"2017-01-17T21:56:34+00:00","dateModified":"2021-07-20T22:29:37+00:00","description":"The Maves Lab is making key discoveries about how muscle cell differentiation is controlled.","breadcrumb":{"@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/projects-maves-lab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"CDBRM Home","item":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/"},{"@type":"ListItem","position":2,"name":"Research Labs","item":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/"},{"@type":"ListItem","position":3,"name":"Maves Lab","item":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/"},{"@type":"ListItem","position":4,"name":"Projects"}]}]}},"_links":{"self":[{"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/105"}],"collection":[{"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/comments?post=105"}],"version-history":[{"count":55,"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/105\/revisions"}],"predecessor-version":[{"id":2340,"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/105\/revisions\/2340"}],"up":[{"embeddable":true,"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/12"}],"wp:attachment":[{"href":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/media?parent=105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}