The Nguyen Lab investigates the interplay between genetic and epigenetic factors that drive responses to kidney disease and injury. By bridging scientific investigation with patient-centered care, we aim to redefine outcomes for children with kidney disease and ultimately halt the progression of chronic kidney failure.<\/p>\n\n\n\n
At the Nguyen Lab, we are driven to discover new ways to promote functional kidney repair and prevent the progression of chronic kidney disease. The kidney can be damaged by disease as well as common events such as infection, surgery, and medication. When injured, its ability to fully recover is compromised, often leading to progressive and irreversible chronic kidney disease. While current treatments can slow this decline, there are no therapies that can repair damaged tissue, highlighting the urgent need for new insights. Our research decodes the complex interplay between genetics and epigenetics in the kidney\u2019s response to injury and disease. By understanding the regulatory elements and gene expression pathways involved, we aim to redirect the cellular response away from scarring and toward tissue regeneration. We conduct this work by combining findings from both basic and translational research. We study animal models that have the remarkable ability to regenerate tissue after injury, and we apply these insights to human genetics, with the goal of identifying mechanisms for functional repair. Our collaborative work unites clinicians and scientists, translating our genetic discoveries into tangible solutions for patients. This effort is deeply integrated with my mission as the co-director of the Kidney Genetics Clinic at Seattle Children’s, where we are dedicated to improving care by expanding genetic diagnoses with equitable access, comprehensive education, and advanced research.<\/p>\n","protected":false},"excerpt":{"rendered":"
The Nguyen Lab investigates the interplay between genetic and epigenetic factors that drive responses to kidney disease and injury. By bridging scientific investigation with patient-centered care, we aim to redefine outcomes for children with kidney disease and ultimately halt the progression of chronic kidney failure. At the Nguyen Lab, we are driven to discover new … <\/p>\n