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Carcinogenesis
Research
Core 2
Thomas
Vaughan,
MD, Director
Christopher Kemp, PhD, Co-Director
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Investigators
in this Research Core study carcinogens
found in the environment, workplaces, and our diets, and genetic
variations in the ways our bodies protect themselves against
carcinogens.
Overview
Investigator Directory
2005
Research Highlights
Overview
Because
the development of cancer is a complex multi-stage process that
is influenced by genetic, environmental, and endogenous (internal)
risk factors, understanding how our environment influences the
chances of getting cancer requires an interdisciplinary approach.
The goal of the Carcinogenesis Research Core is to stimulate
interdisciplinary
research into the complex gene-environment interactions that
define individual cancer risk.
The
Carcinogenesis Research Core emphasizes
basic studies of molecular and genetic mechanisms of how chemicals
and other factors in our environment cause cancer (carcinogenesis).
Results from these studies are expected to yield new insights
into specific genes that contribute to the development and
growth
of cancer cells in the body. Studies in human populations with
cancer (basic epidemiology studies) will also contribute to
understanding
of environmental and endogenous risk factors that increase
or decrease cancer risk.
By fostering and supporting research in these areas, the
Core hopes to move closer to its central goals: understanding
how
an
individual’s genetic constitution predicts risk from a given
exposure, and developing interventions to reduce an individual’s
lifetime risk of cancer.
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Specific
Aims
- Increase
communication and interactions among Core and CEEH investigators,
with particular emphasis on developing a common language
for interdisciplinary studies designed to define the role
of gene-environment interactions in the etiology of cancers.
- Foster
the development of interactive grants to carry out interdisciplinary
research on the role of gene/environment interactions in
the pathogenesis of human cancers..
- Serve
as a conduit for access of Core faculty to emerging genomic
and proteomic technologies by facilitating cooperative
interactions and collaborations.
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Vaughan,
Thomas Core Director |
Epidemiology,
Fred Hutchison Cancer Research Center (FHCRC) |
Kemp,
Christopher
Core Co-Director |
FHCRC |
| De
Roos, Anneclaire |
Epidemiology |
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Eaton,
David L.
(CEEH Director) |
Environmental
and Occupational Health Sciences |
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Fausto,
Nelson |
Pathology |
Ladiges,
Warren
(FC4 Director) |
Comparative
Medicine |
| Lampe,
Joanna |
Epidemiology |
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Loeb,
Lawrence |
Pathology |
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Monnat,
Ray |
Pathology |
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Nickerson,
Debbie |
Genome
Sciences, Bioengineering |
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Potter,
John |
Epidemiology |
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Preston,
Bradley |
Pathology |
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Rossing,
Mary Anne |
Epidemiology |
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Schwartz,
Stephen |
Epidemiology |
| Williams,
Michelle |
FHCRC,
Epidemiology |
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Ulrich,
Neli |
FHCRC,
Epidemiology |
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