CEEH Publications
The list below includes all publications from 2008 through January 2009 that were supported by the CEEH. A complete list of CEEH-supported publications from January 2005 through January 2009 is also available (download PDF).
Current Publications - January 2008 through January 2009 (CEEH Affiliates are in bold)
Bar, M., Wyman, S. K., Fritz, B. R., Qi, J., Garg, K. S., Parkin, R. K., Kroh, E. M., Bendoraite, A., Mitchell, P. S., Nelson, A. M., Ruzzo, W. L., Ware, C., Radich, J. P., Gentleman, R., Ruohola-Baker, H., and Tewari, M., (2008). MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells 26, 2496-2505.
Bea, F., Hudson, F. N., Neff-Laford, H., White, C. C., Kavanagh, T. J., Kreuzer, J., Preusch, M. R., Blessing, E., Katus, H. A., and Rosenfeld, M. E. (2009). Homocysteine stimulates antioxidant response element-mediated expression of glutamate-cysteine ligase in mouse macrophages. Atherosclerosis 203, 105-111.
Berg C., Fryer-Edwards K. (2008). The ethical challenges of direct-to-consumer genetic testing. Journal of Business Ethics 77(1):17-31.
Biggs, M. L., Davis, M. D., Eaton, D. L., Weiss, N. S., Barr, D. B., Doody, D. R., Fish, S., Needham, L. L., Chen, C., and Schwartz, S. M., 2008. Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 17, 2012-2018.
Botta, D., White, C. C., Vliet-Gregg, P., Mohar, I., Shi, S., McGrath, M. B., McConnachie, L. A., and Kavanagh, T. J., (2008). Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice. Drug Metab Rev 40, 465-477.
Carlsten, C., Sagoo, G. S., Frodsham, A. J., Burke, W., and Higgins, J. P., (2008). Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis. Am J Epidemiol 167, 759-774.
Cekan, P., Smith, A. L., Barhate, N., Robinson, B. H., and Sigurdsson, S. T., 2008. Rigid spin-labeled nucleoside C: a nonperturbing EPR probe of nucleic acid conformation. Nucleic Acids Res 36, 5946-5954.
Chen, C. Y., Guo, H. H., Shah, D., Blank, A., Samson, L. D., and Loeb, L. A., (2008). Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst) 7, 1731-1745.
Chen, J., Ryu, S., Gharib, S.A., Goodlett, D.R., Schnapp, L.M. (2008). Exploration of the normal human bronchoalveolar lavage fluid proteome. Proteomics Clin. Appl. 2, 585-595.
Choi, S. U., Bui, T., and Ho, R. J., (2008). pH-dependent interactions of indinavir and lipids in nanoparticles and their ability to entrap a solute. J Pharm Sci 97, 931-943.
Choi, W. S., Kruse, S. E., Palmiter, R. D., and Xia, Z., (2008). Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A 105, 15136-15141.
Cullen, A. C., Corrales, M. A., Kramer, C. B., and Faustman, E. M., 2008. The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach. Risk Anal 28, 877-890.
Enquobahrie, D. A., Rice, K., Williams, O. D., Williams, M. A., Gross, M. D.,Lewis, C. E., Schwartz, S. M., and Siscovick, D. S. (2009). IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study. Atherosclerosis 202, 513-520.
Gao, Q., Xue, S., Shaffer, S. A., Doneanu, C. E., Goodlett, D. R., and Nelson, S. D., (2008). Minimize the detection of false positives by the software program DetectShift for 18O-labeled cross-linked peptide analysis. Eur J Mass Spectrom (Chichester, Eng) 14, 275-280.
Giordano, G., Kavanagh, T. J., and Costa, L. G. (2008). Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol 232, 161-168.
Giordano, G., Klintworth, H. M., Kavanagh, T. J., and Costa, L. G., (2008). Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases. Neurochem Int 52, 1100-1105.
Giordano, G., Li, L., White, C. C., Farin, F. M., Wilkerson, H. W., Kavanagh, T. J., and Costa, L. G. (2009). Muscarinic receptors prevent oxidative stress-mediated apoptosis induced by domoic acid in mouse cerebellar granule cells. J Neurochem 109, 525-538.
Goo, Y. A., Liu, A. Y., Ryu, S., Shaffer, S. A., Malmstrom, L., Page, L., Nguyen, L. T., Doneanu, C. E., and Goodlett, D. R. (2009). Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics. Prostate 69, 49-61.
Gorden, N. T., Arts, H. H., Parisi, M. A., Coene, K. L., Letteboer, S. J., van Beersum, S. E., Mans, D. A., Hikida, A., Eckert, M., Knutzen, D., Alswaid, A. F., Ozyurek, H., Dibooglu, S., Otto, E. A., Liu, Y., Davis, E. E., Hutter, C. M., Bammler, T. K., Farin, F. M., Dorschner, M., Topcu, M., Zackai, E. H., Rosenthal, P., Owens, K. N., Katsanis, N., Vincent, J. B., Hildebrandt, F., Rubel, E. W., Raible, D. W., Knoers, N. V., Chance, P. F., Roepman, R., Moens, C. B., Glass, I. A., and Doherty, D., 2008. CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. Am J Hum Genet 83, 559-571.
Green, P. S., Vaisar, T., Pennathur, S., Kulstad, J. J., Moore, A. B., Marcovina, S., Brunzell, J., Knopp, R. H., Zhao, X. Q., and Heinecke, J. W., (2008). Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation 118, 1259-1267.
Guizzetti, M., Moore, N. H., Giordano, G., and Costa, L. G., (2008). Modulation of neuritogenesis by astrocyte muscarinic receptors. J Biol Chem 283, 31884-31897.
Guizzetti, M., Pathak, S., Giordano, G., and Costa, L. G. (2005). Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 215, 182-190.
Guo, Y., Breeden, L. L., Fan, W., Zhao, L. P., Eaton, D. L., and Zarbl, H. (2006). Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays. Mutat Res 593, 121-142.
Guo, Y., Breeden, L. L., Zarbl, H., Preston, B. D., and Eaton, D. L. (2005). Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. Mol Cell Biol 25, 5823-5833.
Gurer-Orhan, H., Ercal, N., Mare, S., Pennathur, S., Orhan, H., and Heinecke, J. W. (2006). Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids. Biochem J 395, 277-284.
Hallstrand, T.S., Debley, J.S., Farin, F.M., Henderson, W.R., Jr. (2007). Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction. J Allergy Clin Immunol 119(5):1092-1098.
Harrelson, J. P., Atkins, W. M., and Nelson, S. D., (2008). Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics. Biochemistry 47, 2978-2988.
Hashizume, T., Xu, Y., Mohutsky, M. A., Alberts, J., Hadden, C., Kalhorn, T. F., Isoherranen, N., Shuhart, M. C., and Thummel, K. E., (2008). Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol 75, 1240-1250.
Heyer, N. J., Echeverria, D., Farin, F. M., and Woods, J. S., (2008). The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. J Toxicol Environ Health A 71, 1318-1326.
Heyer, N. J., Echeverria, D., Martin, M. D., Farin, F. M., and Woods, J. S. (2009). Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. J Toxicol Environ Health A 72, 599-609.
Hosako, H., Francisco, L. E., Martin, G. S., and Mirkes, P. E. (2009). The roles of p53 and p21 in normal development and hyperthermia-induced malformations. Birth Defects Res B Dev Reprod Toxicol 86, 40-47.
Hussain, S. K., Madeleine, M. M., Johnson, L. G., Du, Q., Malkki, M., Wilkerson, H. W., Farin, F. M., Carter, J. J., Galloway, D. A., Daling, J. R., Petersdorf, E. W., and Schwartz, S. M., (2008). Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2. Cancer Epidemiol Biomarkers Prev 17, 1790-1799.
Jones, J. W., Shaffer, S. A., Ernst, R. K., Goodlett, D. R., and Turecek, F., (2008). Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach. Proc Natl Acad Sci U S A 105, 12742-12747.
Kathiresan, S., Voight, B. F., Purcell, S., Musunuru, K., Ardissino, D., Mannucci, P. M., Anand, S., Engert, J. C., Samani, N. J., Schunkert, H., Erdmann, J., Reilly, M. P., Rader, D. J., Morgan, T., Spertus, J. A., Stoll, M., Girelli, D., McKeown, P. P., Patterson, C. C., Siscovick, D. S., O'Donnell, C. J., Elosua, R., Peltonen, L., Salomaa, V., Schwartz, S. M., Melander, O., Altshuler, D., Merlini, P. A., Berzuini, C., Bernardinelli, L., Peyvandi, F., Tubaro, M., Celli, P., Ferrario, M., Fetiveau, R., Marziliano, N., Casari, G., Galli, M., Ribichini, F., Rossi, M., Bernardi, F., Zonzin, P., Piazza, A., Yee, J., Friedlander, Y., Marrugat, J., Lucas, G., Subirana, I., Sala, J., Ramos, R., Meigs, J. B., Williams, G., Nathan, D. M., MacRae, C. A., Havulinna, A. S., Berglund, G., Hirschhorn, J. N., Asselta, R., Duga, S., Spreafico, M., Daly, M. J., Nemesh, J., Korn, J. M., McCarroll, S. A., Surti, A., Guiducci, C., Gianniny, L., Mirel, D., Parkin, M., Burtt, N., Gabriel, S. B., Thompson, J. R., Braund, P. S., Wright, B. J., Balmforth, A. J., Ball, S. G., Hall, A. S., Linsel-Nitschke, P., Lieb, W., Ziegler, A., Konig, I., Hengstenberg, C., Fischer, M., Stark, K., Grosshennig, A., Preuss, M., Wichmann, H. E., Schreiber, S., Ouwehand, W., Deloukas, P., Scholz, M., Cambien, F., Li, M., Chen, Z., Wilensky, R., Matthai, W., Qasim, A., Hakonarson, H. H., Devaney, J., Burnett, M. S., et al. (2009). Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41, 334-341.
Lauterbach, M., Martins, I. P., Castro-Caldas, A., Bernardo, M., Luis, H., Amaral, H., Leitao, J., Martin, M. D., Townes, B., Rosenbaum, G., Woods, J. S., and Derouen, T., (2008). Neurological outcomes in children with and without amalgam-related mercury exposure: seven years of longitudinal observations in a randomized trial. J Am Dent Assoc 139, 138-145.
Lefebvre, K. A., Tilton, S. C., Bammler, T. K., Beyer, R. P., Srinouanprachan, S., Stapleton, P. L., Farin, F. M., and Gallagher, E. P., (2009). Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci 107, 65-77.
Lutz, J. D., Dixit, V., Yeung, C. K., Dickmann, L. J., Zelter, A., Thatcher, J. E., Nelson, W. L., and Isoherranen, N. (2009). Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase. Biochem Pharmacol 77, 258-268.
Madeleine, M. M., Johnson, L. G., Smith, A. G., Hansen, J. A., Nisperos, B. B., Li, S., Zhao, L. P., Daling, J. R., Schwartz, S. M., and Galloway, D. A., (2008). Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. Cancer Res 68, 3532-3539.
Matsuo, A. Y., Gallagher, E. P., Trute, M., Stapleton, P. L., Levado, R., and Schlenk, D., (2008). Characterization of Phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch). Comp Biochem Physiol C Toxicol Pharmacol 147, 78-84.
McConn, D. J., 2nd, Lin, Y. S., Mathisen, T. L., Blough, D. K., Xu, Y., Hashizume, T., Taylor, S. L., Thummel, K. E., and Shuhart, M. C. (2009). Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis. Clin Pharmacol Ther 85, 387-393.
Meiner, V., Friedlander, Y., Milo, H., Sharon, N., Ben-Avi, L., Shpitzen, S., Leitersdorf, E., Siscovick, D. S., and Schwartz, S. M., (2008). Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction. Ann Hum Genet 72, 732-741.
Mikheev, A. M., Mikheeva, S. A., Maxwell, J. P., Rivo, J. V., Rostomily, R., Swisshelm, K., and Zarbl, H., (2008). Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat 112, 263-273.
Mikheev, A. M., Nabekura, T., Kaddoumi, A., Bammler, T. K., Govindarajan, R., Hebert, M. F., and Unadkat, J. D., (2008). Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study. Reprod Sci 15, 866-877.
Mitchell, E. S., Farin, F. M., Stapleton, P. L., Tsai, J. M., Tao, E. Y., Smith-DiJulio, K., and Woods, N. F., (2008). Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition. Menopause 15, 105-111.
Moore, N. H., Costa, L. G., Shaffer, S. A., Goodlett, D. R., and Guizzetti, M. (2009). Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation. J Neurochem 108, 891-908.
Peretz, A., Kaufman, J. D., Trenga, C. A., Allen, J., Carlsten, C., Aulet, M. R., Adar, S. D., and Sullivan, J. H.,(2008). Effects of diesel exhaust inhalation on heart rate variability in human volunteers. Environ Res 107, 178-184.
Peretz, A., Sullivan, J. H., Leotta, D. F., Trenga, C. A., Sands, F. N., Allen, J., Carlsten, C., Wilkinson, C. W., Gill, E. A., and Kaufman, J. D., (2008). Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ Health Perspect 116, 937-942.
Ren, X., Zhang, X., Kim, A. S., Mikheev, A. M., Fang, M., Sullivan, R. C., Bumgarner, R. E., and Zarbl, H., (2008). Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain. Carcinogenesis 29, 177-185.
Richter, R. J., Jarvik, G. P., and Furlong, C. E. (2009). Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol 235, 1-9.
Richter, R.J. Jarvik, G. P. and Furlong, C. E. (2008). Determination of Paraoxonase 1 Status Without the Use of Toxic Organophosphate Substrates. Circ Cardiovasc Genet;1;147-152.
Riehle, K. J., Campbell, J. S., McMahan, R. S., Johnson, M. M., Beyer, R. P., Bammler, T. K., and Fausto, N., (2008). Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 205, 91-103.
Robinson, J. F., Yu, X., Hong, S., Griffith, W. C., Beyer, R., Kim, E., and Faustman, E. M. (2009). Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Toxicol Sci 107, 206-219.
Ryu, S., Gallis, B., Goo, Y.A., Shaffer, S.A., Radulovic, D., Goodlett, D.R., (2008). Comparison of a label-free quantitative proteomic method based on peptide ion current area to the isotope coded affinity tag method. Cancer Informatics 6, 243-255.
Scherl, A., Shaffer, S. A., Taylor, G. K., Hernandez, P., Appel, R. D., Binz, P. A., and Goodlett, D. R., (2008). On the benefits of acquiring peptide fragment ions at high measured mass accuracy. J Am Soc Mass Spectrom 19, 891-901.
Scherl, A., Shaffer, S. A., Taylor, G. K., Kulasekara, H. D., Miller, S. I., and Goodlett, D. R., (2008). Genome-specific gas-phase fractionation strategy for improved shotgun proteomic profiling of proteotypic peptides. Anal Chem 80, 1182-1191.
Scherl, A., Tsai, Y. S., Shaffer, S. A., and Goodlett, D. R., (2008). Increasing information from shotgun proteomic data by accounting for misassigned precursor ion masses. Proteomics 8, 2791-2797.
Searles-Nielsen, S., Mueller, B. A., De Roos, A. J., and Checkoway, H., (2008). Newborn screening archives as a specimen source for epidemiologic studies: feasibility and potential for bias. Ann Epidemiol 18, 58-64.
Shao, J, White CC, Dabrowski MJ, Kavanagh TJ, Eckert ML, Gallagher EP. (2008). The Role of Mitochondrial and Oxidative Injury in BDE 47 Toxicity to Human Fetal Liver Hematopoietic Stem Cells. Toxicol Sci 101(1):81-90
Smith, A. L., Cekan, P., Rangel, D. P., Sigurdsson, S. T., Mailer, C., and Robinson, B. H., (2008). Theory for spin-lattice relaxation of spin probes on weakly deformable DNA. J Phys Chem B 112, 9219-9236.
Smith, H. E., Jones, J. P., 3rd, Kalhorn, T. F., Farin, F. M., Stapleton, P. L., Davis, C. L., Perkins, J. D., Blough, D. K., Hebert, M. F., Thummel, K. E., and Totah, R. A., 2008. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. Pharmacogenet Genomics 18, 943-953.
Stevens, R. C., Suzuki, S. M., Cole, T. B., Park, S. S., Richter, R. J., and Furlong, C. E., (2008). Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Proc Natl Acad Sci U S A 105, 12780-12784.
Templeton, I. E., Thummel, K. E., Kharasch, E. D., Kunze, K. L., Hoffer, C., Nelson, W. L., and Isoherranen, N., (2008). Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clin Pharmacol Ther 83, 77-85.
Wolf, N., Pendergrass, W., Singh, N., Swisshelm, K., and Schwartz, J., 2008. Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. Mol Vis 14, 274-285.
Woods, J. S., Martin, M. D., Leroux, B. G., DeRouen, T. A., Bernardo, M. F., Luis, H. S., Leitao, J. G., Kushleika, J. V., Rue, T. C., and Korpak, A. M., 2008. Biomarkers of kidney integrity in children and adolescents with dental amalgam mercury exposure: findings from the Casa Pia children's amalgam trial. Environ Res 108, 393-399.
Yu, X., Hong, S., and Faustman, E. M., (2008). Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures. Toxicol Sci 104, 385-396.
Yu, X., Robinson, J. F., Gribble, E., Hong, S. W., Sidhu, J. S., and Faustman, E. M., (2008). Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol 233, 389-403.
Zhang, X., and Zarbl, H., (2008). Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue. Cancer Prev Res (Phila Pa) 1, 119-127.