AIDS-Associated Infections and Malignancies Core

About

Cancer is increasingly recognized as an important complication of HIV infection, with ~10% of HIV-infected persons expected to develop cancer at some point in their lifetime. For many HIV-associated malignancies (HIVAM), few good strategies for prevention or treatment exist. Seattle has developed an extraordinary community of researchers in both cancer and HIV, and over the last five years the AIDS-Associated Infections and Malignancies (AAIMs) Scientific Working Group has been highly successful in bringing together these research communities to address HIVAM. We are now expanding the activities of the AAIMs group to become a Core in the UW/FHCRC CFAR, with three Specific Aims: 1)  Enable studies of HIVAM through the development and deployment of assays for the molecular detection and quantification of viral oncogens; 2) Facilitate the diagnosis of HIVAM, as well as detailed studies of HIVAM pathogenesis, in CFAR-affiliated HIV cohorts through the provision of a suite of molecular and immunohistochemical tumor assays; 3)  Disseminate data instruments to accurately identify and characterize cancer endpoints among HIV-infected persons participating in CFAR-affiliated research studies. We have assembled a group of international experts from the Fred Hutchinson Cancer Research Center and the University of Washington to serve on the Core’s Steering Committee, including the services offered by the highly successful Molecular Diagnostics Laboratories in Seattle and Uganda, an expanded core pathology diagnostic services offered by the Hutchinson Center and the Seattle Cancer Care Alliance, and the expertise in data collection of the Statistical Center for HIV/AIDS Research & Prevention.

Services

HHV8 Real Time Quantitative PCR on all types of sample: Plasma, Serum, Saliva, Swabs, Whole Blood, etc.

Activities

Sample Processing, Biorepository, and Molecular Diagnostic services available in Sub-Saharan Africa (Kampala, Uganda)


The approximately 500 square foot Biorepository contains -20 Scientific Freezers, -80 Ultra Low Scientific Freezers, Liquid Nitrogen Storage Tanks, and controlled room temperature storage. We are also able to assist with shipping of samples.


Sample processing services include standard plasma, serum, and buffy coat separation, PBMC isolation by Ficoll separation, granulocyte isolation, solid tissue formalin fixing, snap-freezing of tissues and cells, and cryopreservation capabilities.


Currently we offer HHV8 Real Time Quantitative PCR and anticipate adding similar tests for both HIV and EBV in 2014.

People

Corey Casper Director


Judd Walson Co-Director

Contact

Postal Mailing Address
Fred Hutchinson Cancer Research Center
UCI/Hutchinson Center Cancer Alliance
M1-B140
P.O. Box 19024
Seattle, WA 98109-1024

Shipping Address (FedEX, UPS, etc.)
Fred Hutchinson Cancer Research Center
UCI/Hutchinson Center Cancer Alliance
M1-B140, 1100 Fairview Avenue North
Seattle, WA 98109

Director
Corey Casper , M.D., MPH
(206) 667-4600
ccasper@fhcrc.org

Co-Director
Judd Walson, M.D., MPH
(206) 543-4278
walson@uw.edu

Core Manager
James Ferrenberg
(206) 667-7779
jferrenb@fhcrc.org