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The Biometrics Core provides a central resource of biostatistical expertise to improve the conception, design, and analysis of HIV/AIDS studies.
Any CFAR investigator can consult with Core biostatisticians and quantitative scientists for assistance with study planning and design for grant applications (eg, sample size and power calculations, development of analytical plans), study implementation (eg, data management, statistical analysis), or research communication (eg, drafting of abstracts, posters, or articles).
In addition to collaborating on specific projects with basic, clinical, and scientific researchers, the Core offers training and education in quantitative methods for all CFAR investigators and also provides a multidisciplinary forum for discussion of ideas, trends, and problem-solving tips related to advanced quantitative methods.
The Biometrics Core is collaborating on a range of research projects involving the prevention, pathogenesis, or treatment of HIV/AIDS. Examples include:
Mathematical Modeling of Viral Dynamics and/or Viral Set Point (Dr Holte)
Quantitative Study of Viral Sequences and Viral Reservoirs (Dr Holte, Mr Tapia)
Identifying Predictors of Viral Genital/Rectal Shedding During Antiretroviral Treament (Dr Holte, Mr Tapia)
Seattle Primary Infection Project (Dr Holte, Ms Yuhas)
Optimizing Pediatric HIV-1 Therapy Trials (Mr Tapia)
Comparing Adherence Interventions in Africa (Mr Tapia)
Investigating interactions between the human genital microbiome and syndromes and pathogens (Ms Yuhas)
In addition to research collaborations, the Biometrics Core engages in educational and institutional activities to support multidisciplinary research within the CFAR. These include:
CFAR Award Programs
Each year, Dr Holte provides statistical consultations to various CFAR award programs, including the CFAR Developmental Core New Investigator Awards (NIA) and HIV-Associated Malignancy Research Pilot Awards.
Biostatistics Core for the Seattle Primary Infection Project (PI, James Mullins)
Dr Holte has served as the lead statistician for the Seattle Primary Infection Project since its inception. She continues to collaborate with the group on a variety of mathematical and statistical activities.
Sarah Holte, PhD
sholte at fredhutch.org
Barbra Richardson, PhD
barbrar at u.washington.edu
Ken Tapia, MS
Core Manager, Biostatistician
ktapia at u.washington.edu
Krista Yuhas, MS
yuhask at u.washington.edu
Joshua Stern, MS
jstern77 at u.washington.edu
Pirie Hart, PhD, MBA
Senior Computer Specialist
pirie at u.washington.edu
Core Steering Committee: Ann Collier, MD; Thomas Fleming, PhD; Jim Hughes, PhD; Lisa Manhart, MPH, PhD; Scott McClelland, MD; Jennifer Slyker, PhD