Lisa M. Frenkel

Professor, Pediatrics and Laboratory Medicine; Adjunct Professor, Global Health; University of Washington

CFAR Role:
Associate Director, Clinical and Retrovirology Research Core

Research Interests:
Dr. Frenkel's research focuses on understanding HIV-1-drug-resistance, prevention of mother-to-child-transmission, characteristics of HIV-1 that is transmitted, and mechanisms that allow HIV-1 infection to persist despite suppressive antiretroviral therapy. Her group is also working to develop and transfer practical and economical assays to facilitate HIV-1 diagnosis in infants, and to monitor antiretroviral treatment and drug-resistant mutants in resource-poor communities. Their projects include collaborative studies with colleagues in Kenya, Peru, Thailand, South Africa, the USA and Zimbabwe.

Education:
BA, Kansas University, Lawrence, Kansas, 1973-77
MD, Kansas University Medical School, Kansas City, Kansas, 1977-81
Pediatric Residency, University of California, Los Angeles, California, 1981-84
Infectious Disease Fellowship, University of California, Los Angeles, California, 1984-87

Selected Publications:

Micek MA, Blanco AJ, Beck IA, Dross S, Matunha L, Montoya P, Seidel K, Gantt S, Matediane E, Jamisse L, Gloyd S, Frenkel LM. Nevirapine Resistance by Timing of HIV Type 1 Infection in Infants Treated with Single-Dose Nevirapine. Clin Infect Dis. 2010; 5p(10):1405-1414. PMCID: PMC3038662. [PubMed]

Gantt S, Carlsson J, Heath L, Bull ME, Shetty AK, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA, Mullins JI, Frenkel LM. Genetic analyses of HIV-1 env sequences demonstrate limited 1 compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis. J Virol. 2010; 84(20):10812-10819. PMID: 20660189. PMCID: PMC2950573. [PubMed]

Micek MA, Blanco AJ, Carlsson J, Beck IA, Dross S, Matunha L, Seidel K, Montoya P, Tantt S, Matediana E, Jamisse L, Gloyd S, Frenkel LM. 2011. Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine. J Infect Dis 205(12):1811-1815. PMCID: PMC3415891. [PubMed]

Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kakia A, Odoyo J, Mucunguzi A, Nakku-Joloba E, Twesigye R, Ngure K, Apaka C, Tamooh H, Gabona F, Mujugira A, Panteleeff D, Thomas KK, Kidoguchi L, Krows M, Revall J, Morrison S, Haugen H, Emmanuel-Ogier M, Ondrejcek L, Coombs RW, Frenkel L, Hendrix C, Bumpus NN, Bangsberg D, Haberer JE, Stevens WS, Lingappa JR, Celum C for the Parterns PrEP Study Team. 2012. Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women. N Engl J Med 367(5):399-410. PMID: 22784037. [PubMed]

Wagner T, McKernan J, Tobin N, Tapia K, Mullins J, Frenkel L. 2012. An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells. J Virol. 2013, in press. PMCID: PMC Journal – In Process. [PubMed]

Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM. 2012. Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses, but genital lineages do not persist over time.J Infect Dis. 2013 Jan 11. [Epub ahead of print] PMID: 23315326 PMC Journal – In Process. [PubMed]

Links:
Seattle Children's Profile
Laboratory Medicine Faculty Page

Contact
1900 9th Ave
Seattle WA 98101
Tel: 206-987-5140
Fax: 206-884-7311
lfrenkel at uw.edu