- Discover CFAR
- Find a Service
- Find Funding
- News & Events
- Get Involved
The Computational Biology Core assists researchers in viral sequence analysis.
Investigators at CFAR can partner with Core faculty for accurate and meaningful interpretation of HIV sequence data. Access to advanced computational tools and software expertise ensures high-level quality control in phylogenetic and bioinformatics studies of viral gene and protein sequences. The Core’s array of technologies and data mining methods expands every year to keep pace with the growing HIV-1 database and its affiliated research opportunities in pathogenesis, vaccine development, and therapeutic design.
Essential to its ongoing project-specific work, the Core continually updates its toolkit of analytical technologies and software. We encourage dialogue with tool users and always seek to improve and innovate in response to researchers’ needs. All activities—from project-related work to analytical tool development—serve as practical case studies in the Core’s formal training sessions in sequence analysis.
The Computational Biology Core has contributed analytical expertise to dozens of recent research projects undertaken by CFAR investigators and others in the AIDS/HIV research community. The nature of that project-specific support is exemplified in:
The list of currently available tools in the Services section
The list of Manuscripts Supported by the Computational Biology Core can be found here.
The Core also maintains a long-term goal of creating an all-encompassing database for sequence storage, detailed annotation, integrated analyses, and project management—from bedside to bench to bioinformatics.
In this development work, Core faculty focus on emerging issues related to the massive data output from next-generation HIV sequencing technologies. At the same time, we strive to make our new web-based tools as intuitive and integrated as possible. Examples of this ongoing work include:
Viroverse, a Comprehensive HIV Research Database
HIV-Specific Analysis Tools to Refine Pyrosequencing Output