Thomas Hawn


Associate Professor of Medicine, Division of Infectious Diseases
Adjunct Associate Professor, Department of Global Health

CFAR ROLE:
HIV Co-Morbidities Subcore Director (Immunology Core)

RESEARCH INTERESTS:
We are investigating immunologic mechanisms of disease pathogenesis with an emphasis on genetic, cellular, and molecular studies of the innate immune response. These studies are directed towards understanding why individuals have different susceptibility to infections and whether these insights can lead to novel treatment and vaccine strategies. We are using several approaches to understand this question. First, we are pursuing case-control human genetic studies to find associations of polymorphisms in innate immune response genes with disease susceptibility. Second, we are using ex vivo and in vitro immunologic, cellular and molecular assays to understand how these genes and their variants mediate a protective immune response. Finally, we are complementing these studies with in vivo infection models in mice with targeted gene deletions to elucidate mechanisms of disease pathogenesis. We are using these methods to study the pulmonary innate immune response to Mycobacterium tuberculosis, M. leprae, and Legionella pneumophila.

EDUCATION:
MD (Johns Hopkins University)
PhD (Johns Hopkins University)
AB (Princeton University)

SELECTED PUBLICATIONS:
Hayashi, F, Smith, KD, Ozinsky, A., Hawn, TR, Yi, EC, Goodlett, DR, Eng, JK, Akira, S, Underhill, DM, Aderem, A. The innate immune response to bacterial flagellin is mediated by toll-like receptor-5. Nature. 2001 Apr 26;410(6832):1099-1103. [ PubMed Abstract ]

Hawn, TR, Verbon, A, Lettinga, KD, Zhao, LP, Li, SS, Laws, RJ, Skerrett, SJ, Beutler, B, Schroeder, L, Nachman, A, Ozinsky, A, Smith, KD, Aderem, A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med. 2003 Nov 17;198(10):1563-1572. [ PubMed Abstract ]

Hawn, TR, Verbon, A, Janer, M, Zhao, LP, Beutler, B, Aderem, A. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2487-9. [ PubMed Abstract ]

Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, Siddiqui MR, Kaplan G, Hawn TR. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008 May 7;2(5):e231. PMC2330092. [ PubMed Abstract ]

Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog. 2008 Dec;4(12):e1000229. PMC2585058. [ PubMed Abstract ]

Berrington WR, Macdonald M, Khadge S, Sapkota BR, Janer M, Hagge DA, Kaplan G, Hawn TR. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J Infect Dis. 2010 May 1;201(9):1422-35. PMID: 20350193. [ PubMed Abstract ]

Berrington, WR, Iyer, R., Wells, RD, Smith, KD, Skerrett, SJ, Hawn, TR. (2010) NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophlia. Eur. J. Immunol. 2010 Dec;40:12. 3519-27. [ PubMed Abstract ]

Randhawa, AK, Shey, MS, Keyser, A, Peixoto, B, Wells, RD, de Kock, M, Lerumo, L, Hughes, J, Hussey, G, Hawkridge, A, Kaplan, G, Hanekom, WA, Hawn, TR, and the SATVI team. (2011). Association of Human TLR1 & TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants.PLoS Pathogens. 7: e1002174 (PMC3154845). [ PubMed Abstract ]

Tobin DM, Vary JC Jr, Ray JP, Walsh GS, Dunstan SJ, Bang ND, Hagge DA, Khadge S, King MC, Hawn TR, Moens CB, Ramakrishnan L. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell. 2010 Mar 5;140(5):717-30. PMID: 20211140. [ PubMed Abstract ]

Horne, DJ, Randhawa, AK, Chau, TTH, Bang, ND, Yen, NTB, Farrar, JJ, Dunstan, SJ, Hawn, TR (2012) Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated with Susceptibility to Tuberculosis. J. Inf. Dis. 205: 586-94. [ PubMed Abstract ]

Shah, JA, Vary, JC, Chau, TTH, Bang, ND, Yen, NTB, Farrar, JJ, Dunstan, SJ, Hawn, TR. (2012)  Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.  J. Immunol.  189(4):1737-46.

Seshadri C, Shenoy, M, Wells, RD, Hensley, T, Andersen-Nissen, E, McElrath, MJ, Cheng, TY, Moody, DB, Hawn TR. (2013)  Human CD1a-deficiency is Common and Genetically Regulated.  J. Immunol.  191(4):1586-93

LINKS:
Faculty page

CONTACT
750 Republic St., Box 358061
Seattle, WA 98195-8061
thawn at uw.edu