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The international pilot awards are for development and implementation of innovative and collaborative HIV-related research projects in developing countries by junior faculty. Pilot awards provide an opportunity to initiate new research or to leverage new directions for research within ongoing projects that will provide important preliminary data to seed future larger proposals by junior investigators in international settings. Studies with potential to obtain pilot data for development of future grant proposals are given priority.
To be eligible, a PI must be a junior investigator at a UW/FHCRC CFAR affiliated institution: Fred Hutchinson Cancer Research Center, Seattle BioMed, Seattle Children’s, University of Hawaii and affiliated international institutions (listed here).
Contact email@example.com if you have questions about eligibility.
Types of projects
Research topics could include any aspect of HIV and HIV-related research, but may not include prospective human interventional trials (e.g. clinical trials of new drugs, treatments, or devices; or off-label use of a licensed drug). Studies of animal models, stored samples from existing cohorts, small pathogenesis studies or in vitro trials are acceptable. Project must be primarily conducted in an international location.
If your proposed study design involves testing a biomedical or behavioral intervention (including approved drugs and/or standard of care), please contact the International Core Program Manager by Friday, October 2, 2015 to determine whether the proposed project would be eligible for funding at firstname.lastname@example.org. Please include a brief description of 1) the study group(s), 2) the planned intervention and how it will be assigned, and 3) your proposed outcomes.
Direct costs: $15,000 US over one year. Previously funded projects will not be considered. Funding cannot be applied to alterations or renovations of any facilities or IRB/ERC fees. If the proposal requires a sub-contract, subcontractor F&A costs must be budgeted as a direct cost. Please note that the CFAR has negotiated indirect cost waivers with several local institutions, including Fred Hutch, CIDR (formerly Seattle BioMed) and Seattle Children’s. For international institutions, the allowable F&A rate to be budgeted as a direct cost is 8%. For domestic organizations without an established F&A rate, the default F&A rate is 10%. If the proposal funds work through UW Kenya, the 13% UW Kenya recharge fee must be budgeted as a direct cost.
Intervention Eligibility Check: If your proposed study design involves testing a biomedical or behavioral intervention (including approved drugs and/or standard of care), please contact the International Core Program Manager by Friday, October 2, 2015 to determine whether the proposed project would be eligible for funding at email@example.com. Please include a brief description of 1) the study group(s), 2) the planned intervention and how it will be assigned, and 3) your proposed outcomes.
Letters of Support: Applications must include letters of support from all key personnel including faculty co-investigator(s).
CFAR Membership: All applicants are required to be UW/FHCRC CFAR Members. Information about membership can be found at http://depts.washington.edu/cfar/get-involved/cfar-membership or by contacting Michelle Ward (firstname.lastname@example.org).
Biostatistical Consultation: All applicants strongly advised to discuss their proposal with one of CFAR’s biostatisticians prior to/during the preparation of their application, as the proposals will be evaluated for statistical content. If you are a local investigator, please contact Sarah Holte (email@example.com) to schedule your in-person biostatistical review. You will be required to submit a draft of your methods 48 hours before your consultation. If you are an international investigator, please send a copy of your draft methods to Julia Dettinger (firstname.lastname@example.org) and she will arrange your written consultation with a CFAR biostatistician.
Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced?
Approach: Are the conceptual framework, design, methods, and analyses adequate and appropriate to the aims of the project?
Innovation: Does the project employ novel concepts, approaches or method? Are the aims original and innovative?
Investigators (including relationship to UW/FHCRC CFAR): Is the investigator appropriately trained and well suited to carry out this work? CFAR prioritizes junior investigators and the investigators must meet the eligibility criteria described above.
Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Is there evidence of institutional support? Though projects in any country are eligible, CFAR International target countries include Peru, Kenya, Mozambique, Senegal, Uganda and China.
Feasibility: Is the study feasible given the duration of one year and a budget of $15,000?
Potential for new collaborations: Although we prioritize CFAR links and target particular countries, we are also encouraging relationships with new investigators who are not currently linked to CFAR. We welcome new investigators who bring expertise in new, relevant disciplines to forge interdisciplinary collaborations.
Potential for new research projects and career development: The projects should aid in the development of the investigator by providing important data for a larger NIH (or other) funded study such as an R01.
Per NIH policy, UW/FHCRC CFAR may not release pilot research funds until awardees complete the NIH administrative clearance process. Clearance will require final IRB approval from all participating institutions and documentation of human subjects training from all investigators. This process often takes several months, so please consider it in your timeline. More information on NIH requirements for international studies can be found at:
**Projects that are unable to complete the NIH clearance process within one year of award date are at risk of losing funding**
CFAR support must be acknowledged in all publications derived from CFAR funding. Suggested wording is available here.
A progress report is required annually and upon completion of the project. This should include information about publications, collaborations, and future grants related to your CFAR project.
After fulfilling all pre-submission requirements, submit your application by October 19, 2015 to email@example.com using the following application form. The application, any letters of support, biosketches and any other supporting documentation must be combined into a single PDF. Application sections can be expanded or shortened, however proposal narratives (the application form sections 1 – 12, excluding the budget and biosketches) should be no longer than five pages.
Use of CFAR Resources:
We encourage all applicants to use or contact CFAR Cores or link to CFAR Scientific Working Groups (see below). Information about other CFAR cores and services can be found at http://depts.washington.edu/cfar/find-a-service.
Sociobehavioral Study Consultation: Applicants have the opportunity to have an expert from the Sociobehavioral and Prevention Research Core consult with them regarding their study design. In order to receive this consultation, applicants should contact firstname.lastname@example.org.
Immunological Study Consultation: Applicants proposing an immunology or other appropriate basic research study have the opportunity to have an expert from the Immunology Core consult with them regarding their experimental design. In order to receive this consultation, applicants should contact email@example.com.
Implementation Science Study Consultation: Applicants proposing a study in the field of implementation science have the opportunity to have an expert from the Implementation Science Working Group consult with them regarding their study. In order to receive this consultation, applicants should contact firstname.lastname@example.org.
Health Economics Impact Study Team (HEIST): Applicants proposing to incorporate health economics methods into their study have the opportunity to have an expert in health economics consult with them regarding experimental design. In order to receive this consultation, applicants should contact email@example.com.