Resisting HIV infection – how less might be more

Webcast Date
Keith Fowke, PhD

University of Manitoba

Dr. Fowke received his PhD in Medical Microbiology (1995) from the University of Manitoba (UM) and did a postdoctoral fellowship at the National Institutes of Health in Bethesda, Maryland (1995-1999). In 1999 he was recruited to the UM’s Department of Medical Microbiology is currently a full professor and is cross appointed with the Dept of Community Health Science (UM) and the University of Nairobi. Dr. Fowke’s laboratory focuses on defining cellular immune mechanisms of the control of, and resistance to, HIV infection and studies the immune response to influenza infection and vaccination. Dr. Fowke has a particular interest in training young investigators and has been involved in a number of workshops and international training programs.

This talk will focus on a group of HIV exposed seronegative (HESN) commercial sex workers from Nairobi, Kenya who are intensely exposed to HIV and yet remain uninfected. Recent findings suggest that these HIV resistant women have an immune systems that have reduced basal levels of T cell immune activation, a phenomena we call Immune Quiescence. The talk will explore if Immune Quiescence may be contributing to protection against HIV and what implications that may have for microbicide or vaccine design.

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