Targeting Proviral DNA as Therapy for HIV Infection

Webcast date

October 6, 2011

Keith Jerome, MD, PhD
Fred Hutchinson Cancer Research Center/University of Washington

Chronic viral infections have plagued humanity for millennia. Now infections such as HIV are being targeted by new approaches that raise the possibility of their cure. In this talk Dr. Jerome will explain the use of DNA editing enzymes such as zinc finger nucleases and homing endonucleases to disrupt essential viral nucleic acids, or the human genes encoding receptors needed for viral entry. He will also discuss the potential of this approach for other viruses, including hepatitis B virus, herpes simplex virus, and human papillomavirus, and the challenges ahead in bringing this technology into the clinic for therapeutic use.

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