Sexually Transmitted Infections and Topical Microbicides Cooperative Research Center
Project 1: Comparative Genomics of Clinical C. trachomatis Strains
The genome sequences of seven Chlamydiaceae strains have now been completed, and each provides important and novel insights into many aspects of chlamydial biology and pathogenesis. In parallel, laboratory and clinical studies have revealed significant differences in host-pathogen interaction among the different Chlamydia trachomatis serovars. More...
Project 2: Immunogenetic Correlates of Severity of Genital HSV-2
Our objectives are:
To identify major histocompatibility complex (MHC) class I and II alleles associated with severe vs. mild HSV-2 infection. To determine if HLA class I-restricted cellular immune responses exert selective pressure on HSV-2 amino acid sequences. To create a host DNA repository of samples from HSV-2 infected persons with well-characterized clinical and virologic severity of disease. More...
Project 3: Male Microbicide Safety, Acceptance & Efficacy Against STI
While topical microbicides have a long history of use for prophylaxis against STIs in men, dating back to World Wars I and II, no subsequent clinical trials have examined the efficacy of topical microbicides used on the external genitalia of men to prevent transmission and/or acquisition of STIs, including HIV infection. More...
Project 4: M. genitalium Susceptibility and Treatment
Mycoplasma genitalium has recently been implicated in both male and female reproductive tract infections and may account for up to 25% of all cases of nongonococcal urethritis (NGU). This organism was independently associated with NGU in virtually all studies using DNA amplification methods and, given the strength of this association, it is now appropriate to identify effective treatment regimens for M. genitalium-associated urethritis. More...
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