UW Center for AIDS and STD
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Projects

The UW STI CRC includes four projects supported by four cores that will provide invaluable, centralized and efficient support in the clinical, laboratory, statistical and administrative domains. The projects are tightly integrated both intellectually and operationally. In these projects, we systematically describe the genital microbiome as a fundamental component of the pathogenesis and natural history of the conditions of interest. Critically, our proposals go beyond the descriptive epidemiology that has characterized much of the human microbiome work to date in that they pose specific mechanistic pathways for how these bacterial community members might be altered by external and internal influences (such as sexual behaviors, concurrent infection with HSV-2, menses, and exogenous hormones), and the implications these shifts have for diagnosis, prevention, and management.