Genomics Core People
Samuel Miller, MD, Director, Genomics Core
Dr. Miller is a Professor of Medicine, Microbiology, and Genome Sciences. He is a physician, infectious diseases specialist, and experienced researcher in bacterial pathogenesis and host-pathogen interaction. He has over 15 years experience as a PI in the research area of Genomic Sciences. He is also experienced in the area of cystic fibrosis (CF), and is the former Director of the Cystic Fibrosis Research and Development Program at the University of Washington, now directed by E. Pete Greenberg, and on which he retains direction of the Genomics Core. Dr. Miller also functions as the Director of a Research Center of Excellence in Biodefense and Emerging Infectious Diseases for the region.
Mitch Brittnacher – Research Scientist, leads the Bioinformatics and Statistics group working with the Miller laboratory. He will direct and assist in performing the extensive bioinformatics and statistical analysis required following the DNA sequence and RNA transcript analysis. Dr. Brittnacher has created an important database structure that integrates specific characteristics of Pseudomonas aeruginosa with clinical data and will work closely with Drs. Jacobs and Miller, and other cores to integrate clinical and bacterial data to make important correlations, and in interacting with clinicians and statistical resources directed by the clinical and Immunology cores, and will be responsible for data integration.
Hillary Hayden – Senior Research Scientist. Dr. Hayden oversees the operation, completion and publication of projects. She is team lead for operation of the Illumina MiSeq and HiSeq, and all other high-throughput robotics and molecular biological processes for validation of libraries and sequence polymorphisms. She analyzes data from new-generation sequencers, develops algorithms for data analysis, and maintains comprehensive QC analyses for projects. She assists with sample selection, project initiation and database maintenance, assists in ordering, price negotiation, and grant preparation.
Elizabeth Sims – Research Scientist. Ms. Sims
generates all libraries for use in next generation sequencing, as well
as standard cycle sequencing. Operates and maintains the equipment for
libraries (Illumina Genome Analyzer). Maintains supplies and does all
standard molecular and chemical manipulations for projects.
Hemantha Kulasekara – Research Scientist. Dr. Kulasekara is a Research Scientist working with Dr. Miller. Dr. Kulasekara has generated all the microarray data on P. aeruginosa adaptation to the CF airway. He has extensive experience in microarray and transcript analysis and will assist Dr. Jacobs in advising core users on sample preparation for Illumina and microarray analysis and will advise users on biological significance. He will also work closely with Dr. Brittnacher's group to help users identify biologically relevant information for data integration and various data bases.