A key component of the CFTRC is a pilot and feasibility program that funds 2 pilots for up to 2 years at $75,000/year of direct costs. The pilots must be focused within the goals of the program and can involve investigators from throughout the UW and its affiliate institutions. Outlined below are examples of relevant research topics for this program.
- Promote and expedite the translation of basic laboratory observations into a) better understanding of clinical disease b) improved diagnostic tools for assesing early disease manifestations in CF and/or c) new therapeutic approaches for treating gastrointestinal, hepatic, metabolic (including CF related diabetes mellitus) and lung disease in CF.
- Better understand the impact of bacterial genetic factors and phenotypic characteristics on progression of CF lung disease and GI health and utilize these findings to develop improved therapeutic approaches.
- Better understand host inflammatory responses to bacterial infection to optimize antiinflammatory and anti-infective approaches.
Better understand early infection in infants diagnosed with CF through newborn screening.
Eligibility and related guidelines: Investigators
eligible for pilot and feasibility funding generally fall into three
- New investigators without current or past NIH research support (R01, P01) as a principal investigator (current or past support from other sources should have been modest).
- Established investigators with no previous work in CF who wish to apply their expertise to a problem in this area.
- Established investigators who propose testing innovative ideas that represent clear departure from ongoing research interests.