Case Studies and Models

As described on this website’s homepage, the overall goal of this project is to develop a formal clinical risk-benefit framework to facilitate the translational pathway for genomic technologies using three case studies. Specifically, these case studies are:

  1. Developing a quantitative risk-benefit framework for evaluating the clinical utility of genetic tests in collaboration with stakeholder groups, utilizing warfarin pharmacogenomics as a case example
  2. Assessing the generalizability of the risk-benefit framework by applying it to gene expression profiling in women with early stage breast cancer
  3. Assessing the generalizability of the risk-benefit framework by applying it to Factor V Leiden testing for pregnant women with clotting or adverse pregnancy outcomes

The hyperlinks below will direct you to the case study specific pages and models that display work completed on the Genetic Test Risk-Benefit Framework for Genetic Tests project to date:


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