Current Research Projects

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CENTER	PROJECT INFORMATION	SIGNIFICANT CONTRIBUTORS	FUNDING AGENCY	CLINICAL TOPIC PURPOSE	CHASE CORE
[Nursing]	_{Title :} Nursing Management of IBS: Improving Outcomes _{Project Years :} August 1996 - May 2012 _{Principal Investigator :} Heitkemper, Margaret	Kevin Cain; Monica Jarrett	National Institutes of Health	_{Clinical Topic :} irritable bowel syndrome _{Purpose :} Test the effectiveness of a nutrition+probiotic therapy and a nutrition+short CBT program in patients with IBS as compared to nutrition-counseling & placebo
[Nursing]	_{Title :} Problem Solving/Physical Interventions and Aging _{Project Years :} September 2000 - August 2011 _{Principal Investigator :} Teri, Linda	Eric Larson, Rebecca Logsdon, Sue McCurry	National Institutes of Health	_{Clinical Topic :} dementia care _{Purpose :} Compare modes of intervention in dementia patients on emotional well-being and health behaviors
[Nursing]	_{Title :} Exercise & Health Promotion for MCI: A Controlled Trial _{Project Years :} September 2000 - August 2011 _{Principal Investigator :} Teri, Linda	Rebeca Logsdon, Sue McCurry	National Institutes of Health	_{Clinical Topic :} mild cognitive impairment _{Purpose :} Effectiveness of exercise versus health promotion in reducing decline in mild cognitive impairment
[Nursing]	_{Title :} Psychosocial/Behavioral Intervention in Post Stroke Depression (PSD) _{Project Years :} July 2001 - July 2014 _{Principal Investigator :} Mitchell, Pamela	Kyra Becker; Kevin Cain; Catherine Kirkness, Ruth Kohen; David Tirschwell; Linda Teri; Richard Veith	National Institutes of Health	_{Clinical Topic :} depression after stroke _{Purpose :} Compare effectiveness of in-person versus telephone delivery of brief psychosocial intervention in depression after stroke
[VA HSR&D]	_{Title :} Development of a Cardiac Assessment and Tracking System (CART-CL). _{Project Years :} January 2003 - December 2010 _{Principal Investigator :} Stephan Fihn, MD, MPH		VA Patient Care Services	_{Clinical Topic :} invasive cardiac procedures _{Purpose :} The Cardiac Assessment Reporting and Tracking System – Cath Lab (CART-CL) is a third party software package under development by medical center staff in Seattle and Denver. It is a collaborative effort among Patient Care Services, Office of Information, Office of Quality and Performance, and the Ischemic Heart Disease Quality Enhancement Research Initiative (IHD-QuERI)
[HIPRC]	_{Title :} Strengtening Injury Control Research in Ghana _{Project Years :} June 2005 - February 2011 _{Principal Investigator :} Beth Ebel, MD		Fogarty International Center (NIH)	_{Clinical Topic :} injury control surveillance prevention treatment _{Purpose :} The broad goal of this proposal is to develop a model program to strengthen the training and research capacity for injury control in Ghana. The program will educate a cadre of outstanding scientists and professionals in cutting edge research methods and training techniques. This will facilitate the development of successful and sustainable research and training activities across the spectrum of injury control, including surveillance, prevention, and treatment.
[Nursing]	_{Title :} Behavioral Treatment of Nocturnal Disturbances in AD _{Project Years :} August 2005 - July 2011 _{Principal Investigator :} McCurry, Susan	Linda Teri; Michael Vitiello	National Institutes of Health	_{Clinical Topic :} Alzheimer's _{Purpose :} Compare effectiveness of 4 modes of intervention for Alzheimer's patient with nightime disturbances
[HIPRC]	_{Title :} Injury Control Collaboration with Harborview Injury Prevention and Research Center _{Project Years :} January 2006 - January 2011 _{Principal Investigator :} Beth Ebel, MD		National Highway Traffic Safety Administration	_{Clinical Topic :} Injury Prevention _{Purpose :}
[Nursing]	_{Title :} Dyspnea Self-Management: Internet or Face-to-Face _{Project Years :} March 2006 - May 2011 _{Principal Investigator :} Nguyen, Huong	Joshua Benditt; Seth Wolpin	University of California	_{Clinical Topic :} dyspnea _{Purpose :} Effectiveness of internet dyspnea self-management versus face to face or attention control
[Nursing]	_{Title :} CAST Intervention for Reducing Adolescent Risk Behaviors _{Project Years :} June 2006 - March 2011 _{Principal Investigator :} Thompson, Frances	Carole Hooven	National Institutes of Health	_{Clinical Topic :} Adolescent risk behavior _{Purpose :} Compare effectiveness of school-based programs on adolescent risk behaviors
[Nursing]	_{Title :} Promoting Infant Mental Health in Foster Care _{Project Years :} September 2006 - August 2011 _{Principal Investigator :} Spieker, Susan	Jean Kelly, Maureen Marcenko, Monica Oxford	National Institutes of Health	_{Clinical Topic :} Infant mental health _{Purpose :} Evaluate effectiveness of community developed attachment intervention in foster care
[HIPRC]	_{Title :} Strengthening Injury Control in the Pacific Northwest _{Project Years :} September 2006 - September 2011 _{Principal Investigator :} Beth Ebel, MD		National Highway Traffic Safety Administration	_{Clinical Topic :} injury prevention _{Purpose :} This five-year cooperative agreement supports injury prevention activities in occupant and transportation safety in the Northwest Region, and will support graduate student research in areas of mutual interest.	Health System Evaluation
[SORCE]	_{Title :} Washington State's Use of Venous Thromboembolism (VTE) Chemoprophylaxis and Rates of VTE after Abdominal Surgery _{Project Years :} January 2007 - December 2010 _{Principal Investigator :} David R. Flum, MD	Foundation for Health Care Quality	Sanofi-Aventis	_{Clinical Topic :} Surgery _{Purpose :} The purpose of this grant is to evaluate Washington State’s use of venous thromboembolism (VTE) chemoprophylaxsis, rates of VTE after abdominal surgery, and the changes in the natural history of VTE
[CECORC]	_{Title :} Improving Cognitive Outcome Precision & Responsiveness with modern Psychometrics _{Project Years :} September 2007 - August 2012 _{Principal Investigator :} Crane		National Institute on Aging	_{Clinical Topic :} Alzheimer’s disease, cognition, neuroimaging _{Purpose :} This R01 seeks to analyze data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a large study with serial neuroimaging from a carefully selected cohort of 811 elderly individuals. In addition to neuroimaging data, ADNI also collected an extensive neuropsychological battery at each time point. In this project we use tools of modern psychometrics to develop psychometrically sophisticated composite scores to use in analyses.	Patient Centered Outcomes Technology Assessment
[HIPRC]	_{Title :} Child Safety Seat Intervention for Pacific Northwest Tribes _{Project Years :} January 2008 - January 2013 _{Principal Investigator :} Beth Ebel, MD		NCMHD	_{Clinical Topic :} Injury Prevention _{Purpose :}
[PORPP] [SORCE]	_{Title :} Data Investigation of Bariatric Surgery Outcomes and Economic Savings _{Project Years :} January 2008 - September 2011 _{Principal Investigator :} David R. Flum, MD; Sean Sullivan PhD	Andrew Wright, MD; Lou Garrison, PhD; David Arterburn, MD, MPH;	DOD	_{Clinical Topic :} Obesity; Surgery _{Purpose :} The goal of this project is to use collected data and modeling techniques to create a portfolio of research on the economics of obesity and its treatments
[PORPP]	_{Title :} Risk-Benefit Framework for Genetic Tests _{Project Years :} January 2008 - September 2012 _{Principal Investigator :} David Veenstra, PhD		CDC	_{Clinical Topic :} Genetic Testing _{Purpose :} This project will develop a systematic, quantitative approach for assessing clinical risks and benefits of genetic tests, using a consensus development process with multiple stakeholders.
[PORPP]	_{Title :} SPS - Stergachis _{Project Years :} April 2008 - March 2012 _{Principal Investigator :} Andy Stergachis, PhD Lou Garrison, PhD		Management Sciences for Health	_{Clinical Topic :} Pharmacy; medicine; drugs _{Purpose :} The purpose of this proposal is to build institutional and individual capacity within developing countries to effectively and efficiently manage pharmaceutical systems, protect public health through improved governance in the pharmaceutical sector, and enable the increased use and successful implementation of population, health and nutrition priority services by improving the availability and use of medicines of assured quality.
[Nursing]	_{Title :} The ACTIve intervention to Improve Hopsice Caregiver Pain management _{Project Years :} May 2008 - April 2011 _{Principal Investigator :} Demiris, George	Ardith Doorenbos	National Institutes of Health	_{Clinical Topic :} hospice care _{Purpose :} Effectiveness of videophone in hospice intervention; compare costs of in-person vs videophone
[HIPRC]	_{Title :} Child Safety Seat Intervention for Pacific Northwest Tribes _{Project Years :} May 2008 - January 2013 _{Principal Investigator :} Beth Ebel, MD		NCMHD	_{Clinical Topic :} child safety _{Purpose :} Using a community based participatory research model, we propose to plan, implement, and evaluate child safety interventions in 6 Northwestern tribal communities in a case-crossover design. We anticipate that well designed, tribe-implemented programs will eliminate barriers, increase proper child restraint through a participatory, community-based intervention.
[CECORC]	_{Title :} English and Spanish Assessment of Cognition in Elderly _{Project Years :} August 2008 - May 2013 _{Principal Investigator :} Mungas	Crane	National Institute on Aging	_{Clinical Topic :} Neuropsychology, cognitive assessment _{Purpose :} The SENAS (Spanish and English Neuropsychological Assessment Scales) have been developed over the past several cycles of this grant. This cycle the focus turns to bias assessment, specifically differential item functioning (DIF).	Patient Centered Outcomes
[CECORC]	_{Title :} Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule _{Project Years :} September 2008 - July 2012 _{Principal Investigator :} Jeffrey G. Jarvik, MD, MPH		Oregon Health & Science University	_{Clinical Topic :} Spinal Stenosis _{Purpose :} To examine spine surgery rates for spinal stenosis among the elderly in the United States and whether they continue to rise, and if the introduction of interbody fusion cages results in acceleration of surgery rates; to examine whether or not re-operation rates are increasing over time; to determine if certain surgical procedures are associated with unusually high rates of re-operations; to document the trends for ambulatory disc surgery to replace inpatient disc surgery.	Comparative Effectiveness
[CECORC]	_{Title :} 3D-CAM: Deriving and Validating a 3-minute Diagnostic Assessment for Delirium _{Project Years :} September 2008 - June 2012 _{Principal Investigator :} Marcantonio	Crane	National Institute on Aging	_{Clinical Topic :} Delirium _{Purpose :} This study seeks to develop a 3-minute tool for identifying delirium in hospitalized patients.	Patient Centered Outcomes
[Nursing]	_{Title :} Improving Medication Adherence for Patients with Low Functional Health Literacy: An Intervention with Talking Pill Bottles _{Project Years :} September 2008 - July 2011 _{Principal Investigator :} Wolpin, Seth	Donna Berry, Ann Kurth, Annie Lam, William Lober	National Institutes of Health	_{Clinical Topic :} medication adherence _{Purpose :} Compare technologies for enhancing medication adherence in low literacy
[SeaQoL]	_{Title :} Patient reported outcomes in routine clinical care of patients infected with HIV _{Project Years :} January 2009 - January 2013 _{Principal Investigator :} Donald L. Patrick, PhD, MSPH, Heidi M. Crane, MD, MPH, Paul K. Crane, MD, MPH	Todd Edwards, PhD, Ed Wagner, MD, MPH, Leo Morales, MD, PhD, Laura Gibbons, PhD, Mari Kitahata, MD, MPH, Rosa Solario, MD, MPH, Judith Shaefer, MPH, Ann Collier, MD, James Ralston, MD, MPH,Michael Mugavero, MD, Erika Austin, PhD, Michael Saag, MD, Joseph Schumacher, PhD, James Willig, MD, Donna Porter, PhD	NIAMS	_{Clinical Topic :} HIV; Depression; Physical Health _{Purpose :} Integrate PRO Measurement Information System (PROMIS) data with other data captured during clinical care of Spanish- and English-speaking patients infected with HIV and improve medical care processes and patient outcomes in clinical practice settings
[Nursing]	_{Title :} Psychoeducation for Spouses of Women with Breast Cancer _{Project Years :} May 2009 - April 2011 _{Principal Investigator :} Lewis, Frances	Kristen Fletcher; Mary Shands; Ellen Zahlis	National Institutes of Health	_{Clinical Topic :} psychosocial aspects of cancer _{Purpose :} Compare modes of delivery of couples therapy on reduction of psychosocial morbidity, increase psychosocial functioning, and enhance the quality of life of women and spouses affected by breast cancer
[Nursing]	_{Title :} Patient and Intimate Partner Intervention to Improve Outcome After an ICD _{Project Years :} July 2009 - June 2014 _{Principal Investigator :} Dougherty, Cynthia	Peter Kudenchuk; Frances Thompson	National Institutes of Health	_{Clinical Topic :} Arrythmia _{Purpose :} This research project will test the outcomes of an intervention designed to enable patient/family participation in interdisciplinary teams (IDTs) through use of a commercially available videophone
[CECORC]	_{Title :} Patient Reported Outcomes in Routine Clinical Care of Patients Infected with HIV _{Project Years :} September 2009 - July 2013 _{Principal Investigator :} Heidi Crane, Paul Crane & Donald Patrick		NIAMSD	_{Clinical Topic :} HIV, patient reported data, quality of life _{Purpose :} This U01 is part of the PROMIS initiative – Patient Reported Outcomes Measurement Information System. PROMIS is a large multi-site Roadmap Initiative with 12 PROMIS Research Sites and 3 Coordinating Centers. The UW project is situated in clinical care settings in the CNICS (CFAR Network of Integrated Clinical Systems, where CFAR stands for Centers For AIDS Research) Network of 9 HIV clinics across the US. We are evaluating several established PROMIS domains as well as developing a new one, and working closely with clinicians and patients to integrate collection and reporting of patient reported data in real time at the point of care.	Patient Centered Outcomes Comparative Effectiveness
[CECORC]	_{Title :} Alzeheimer’s Disease Patient Registry (ADPR) The Adult Changes of Thought (ACT) _{Project Years :} September 2009 - August 2014 _{Principal Investigator :} Larson	Crane	National Institute on Aging	_{Clinical Topic :} Alzheimer’s disease _{Purpose :} The ACT study comprises a prospective cohort study of some 4400 elderly Group Health members to date. Participants are dementia free at baseline and evaluated with cognitive testing every two years. The study started in 1994 and has had continuous funding since. The study has amassed a wealth of data on participants. Specific aims this cycle focus on four brain outcomes: dementia and AD, cognitive decline, neuropathological outcomes from fixed tissues, and neuropathological outcomes from frozen brain tissues. The study has completed 400 autopsies. A systematic chart review effort is underway to collect about 150 medical conditions from paper charts that extend back an average of 30 years prior to ACT study entry. Genome wide SNPs are available for much of the cohort and efforts are underway to expand those numbers. This cycle’s specific aims focus on hyperglycemia and insulin resistance, atrial fibrillation and anticoagulation, renal functioning, and relationships between physical performance, frailty, and brain outcomes.	Patient Centered Outcomes Comparative Effectiveness
[HSERV] [PORPP]	_{Title :} CER Administrative Supplement- Workforce Development (ARRA) _{Project Years :} September 2009 - September 2012 _{Principal Investigator :} Disis, Mary	Sean Sullivan, PhD; Larry Kessler, ScD; Pam Mitchell, PhD	National Center for Research Resources	_{Clinical Topic :} Comparative Effectiveness Research (CER) _{Purpose :} The specific aims for this project are: 1) Develop, implement and evaluate a state-of-the-art CER lecture series (ie. grand rounds) 2). Develop curriculum and hands-on training activities for a weeklong summer Symposposim for CER education designed to educate clinical and translational scientists at all levels of career development, including train-the-trainer component to promote dissemination and adoption of CER in our partner communities, and 3) Disseminate the educational materials broadly in the form of a web-based electronic toolkit
[PORPP]	_{Title :} Comparative Effectiveness Research in Genomics and Personalized Medicine _{Project Years :} September 2009 - August 2012 _{Principal Investigator :} David Veenstra, PhD	Lou Garrison, PhD	Center for Comparative Effectiveness Research in Cancer Genomics – CANCERGEN	_{Clinical Topic :} Cancer; Genomics _{Purpose :} Evaluation of the clinical and economic outcomes of genomic test.
[HSERV] [PORPP]	_{Title :} ADVancing Innovative Comparative Effectiveness research-cancer diagnostics - ADVICE _{Project Years :} October 2009 - August 2012 _{Principal Investigator :} Larry Kessler ScD; Sean Sullivan PhD	Scott Ramsey, MD	NCI	_{Clinical Topic :} Cancer _{Purpose :} Establish a resource for CER on cancer diagnostics using multiple existing data sources
[VA HSR&D]	_{Title :} Quality Information Resource Center. _{Project Years :} October 2009 - September 2010 _{Principal Investigator :} Stephan Fihn, MD, MPH		VA Patient Care Services	_{Clinical Topic :} risk models _{Purpose :} Goal is to build predictive risk models that will be used to classify patients into clinically relevant risk categories for case management.
[VA HSR&D]	_{Title :} Patient Centered Medical Home Demonstration Lab Coordinating Center. _{Project Years :} April 2010 - March 2012 _{Principal Investigator :} Stephan Fihn, MD, MPH		VA Patient Care Services	_{Clinical Topic :} Patient Centered Medical Home (PCMH) Demonstration Laboratories _{Purpose :} To facilitate the work of the Patient Centered Medical Home (PCMH) Demonstration Laboratories, the Primary Care Program Office has decided to designate the oversight of the five Laboratories to a Coordinating Center.
[PORPP]	_{Title :} CHGE _{Project Years :} April 2010 - March 2015 _{Principal Investigator :} Wylie Burke, MD Lou Garrison, PhD Dave Veenstra, PhD		NIH/NHGRI	_{Clinical Topic :} _{Purpose :} proj_purpose	proj_expert
[SORCE]	_{Title :} Surgical Disparities in American Indian/Alaska Native Populations in Lung, Breast, Prostate, and Colorectal Cancer _{Project Years :} May 2010 - April 2014 _{Principal Investigator :} David R. Flum, MD, MPH	Tom Varghese, MD, MSc; Sara Javid, MD; Mike Porter, MD, MPH; Lori Arviso Alvord, MD; Ardith Doorenboos, RN, PhD; Arden Morris, MD, MPH	NCI	_{Clinical Topic :} Cancer; Surgery _{Purpose :} A project as part of a population health center grant, this project examine influences ranging from organizational to individual factors on outcomes among AI/ANs undergoing surgery for the most common cancers
[PORPP]	_{Title :} ARRA CHASE Training _{Project Years :} June 2010 - June 2013 _{Principal Investigator :} Sean Sullivan, PhD Dave Veenstra, PhD		AHRQ	_{Clinical Topic :} _{Purpose :} The issues facing healthcare systems in the United States today are complex and raise questions as to whether we are generating and utilizing evidence of the relative benefits and harms of medical interventions wisely to improve health across the population. The answers to these questions require sophisticated, interdisciplinary research. A new cadre of researchers is needed that can not only design and conduct innovative and pragmatic comparative effectiveness research (CER) studies, but also implement findings from CER in a variety of complex healthcare settings. Comparative effectiveness research is the conduct and synthesis of research comparing alternative interventions designed to diagnose, treat and monitor health conditions in “real world” settings. The purpose of CER is to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision-makers about which interventions are most effective for which patients under specific circumstances. An important aspect of CER is responding to priority areas for stakeholders with targeted and timely research intended to inform decision-making. In response to this K12 FOA, we plan to provide intensive, supervised research and methodology training in order to foster scientists able to undertake comparative effectiveness research.
[SORCE]	_{Title :} Feasibility, Efficacy, and Mechanisms of Surgical vs. Medical Diabetes Treatment _{Project Years :} July 2010 - June 2013 _{Principal Investigator :} David R. Flum, MD, MPH; David E. Cummings, MD	Mario Kratz, PhD; Karen Foster Schubert, MD; David Arterburn, MD, MPH	NIDDK	_{Clinical Topic :} Diabetes; Surgery _{Purpose :} Identify and overcome barriers to execute a randomized clinical trial in the USA of gastric bypass surgery vs. an optimal medical/lifestyle intervention to treat type 2 diabetes mellitus in patients with a BMI of 30-40 kg/m2.
[PORPP]	_{Title :} Pharmacogenetics _{Project Years :} July 2010 - June 2015 _{Principal Investigator :} Ken Thummel, PhD Dave Veenstra, PhD		NIGMS	_{Clinical Topic :} _{Purpose :} Genetic testing offers the opportunity to identify sources of inter-individual variability in drug disposition and response, with the goal of individualizing therapy (drug selection and dose) and improving patient and public health outcomes. A small number of pharmacogenetic tests are already in clinical use, and other promising examples are emerging, including tests to improve the safety of warfarin, tamoxifen and tacrolimus therapy. Despite this promise, most studies have been undertaken in resource-intensive, tertiary care centers and their relevance for rural health care practice is unknown. Information gaps are especially notable for Alaska Native and American Indian (AN/AI) communities living in rural locations; addressing these gaps requires attention to scientific, health service and cultural issues. With these uncertainties and knowledge gaps in mind, we propose to create a new Center on Pharmacogenetics in Rural and Underserved Populations. This Center will work in partnership with indigenous communities in Anchorage and the Yukon-Kuskowkim Delta in Alaska and on the Flathead Reservation in Montana, and with rural providers in these locations and in rural Washington, to ensure that there is adequate community understanding, biological knowledge, and medical infrastructure to respond appropriately to national recommendations or mandates related to pharmacogenetics. Our Center will utilize community-based participatory research methods to evaluate community and clinical perspectives on pharmacogenetics; pursue foundational research in AN/AI and rural communities related to genetic variation and response to warfarin, tamoxifen and tacrolimus therapy; evaluate gene-environment interactions related to coagulation factors in one indigenous community; and lay the groundwork for a research infrastructure linking rural practices to pharmacogenetics researchers.
[HIPRC]	_{Title :} Costs and Benefits of Teen Driver Intervention _{Project Years :} July 2010 - June 2015 _{Principal Investigator :} Beth Ebel, MD		NIH	_{Clinical Topic :} crash and injury among teen drivers _{Purpose :} The project goal is to study the costs and benefits of in-vehicle monitored driving for new teen drivers. T
[PORPP]	_{Title :} ARRA BOLD CHOICE _{Project Years :} July 2010 - September 2013 _{Principal Investigator :} Gail P. Jarvik, MD Sean Sullivan, PhD		AHRQ	_{Clinical Topic :} _{Purpose :} The overall goal of this project is to establish a sustainable and rich registry to evaluate prospectively the effectiveness, safety, and cost-effectiveness of interventions for patients over age 65 with low back pain.
[PORPP]	_{Title :} Benefit-Risk Balance _{Project Years :} August 2010 - August 2012 _{Principal Investigator :} Lou Garrison, PhD		Amylin Pharmaceuticals, Inc.	_{Clinical Topic :} Cancer _{Purpose :} Exenatide—both twice daily and once weekly--have well established clinical benefit. Two concerns about the potential risks (or harms) at this point are for pancreatitis and thyroid cancer. Given the rarity of events, detecting any signals against background noise is a challenge for epidemiologists and pharmacovigilance experts. However, a health outcomes model can help assess whether the risks should be a concern as compared to benefits.
[PORPP] [SORCE]	_{Title :} SCOAP CER Translation Network _{Project Years :} September 2010 - September 2013 _{Principal Investigator :} David Flum, MD, MPH Sean Sullivan, PhD		AHRQ	_{Clinical Topic :} _{Purpose :} The state of Washington has in place a regional health information organization (RHIO) that collects patient level clinical data in the context of the surgical setting – the Surgical Care and Outcomes Assessment Program (SCOAP). Currently, centers contribute data to SCOAP through manual abstraction. The first aim of this grant is to connect each of these disparate electronic health records, creating a common data platform using Microsoft’s Amalga Unified Intelligence SystemTM (Amalga UISTM), thereby creating the E-HOAP CER Network. The second aim is to demonstrate the usability of the E-HOAP network by conducting a comparative study of treating peripheral vascular disease with stents versus surgery.
[HIPRC]	_{Title :} Comparative Effectiveness of Two Interventions for Teen Distracted Driving. _{Project Years :} September 2010 - August 2012 _{Principal Investigator :} Beth Ebel, MD		CDC	_{Clinical Topic :} Teen driving _{Purpose :} The project proposes to measure the comparative effectiveness of several in-vehicle technologies aiming to reduce teen distracted driving.
[PORPP]	_{Title :} Pragmatic Trial of Colony Stimulating Factors with Intermediate Risk Chemotherapy _{Project Years :} September 2010 - August 2013 _{Principal Investigator :} Scott Ramsey, MD	Sean D. Sullivan, PhD	AHRQ	_{Clinical Topic :} cancer; chemotherapy treatment _{Purpose :} This pragmatic clinical trial will compare the clinical and economic effectiveness of a guideline-informed, protocol-based intervention for prescribing primary prophylactic colony stimulating factors (CSFs) with usual care in patients with breast, non-small cell lung, or colorectal cancer receiving their first course of neoadjuvant, adjuvant, or palliative cytotoxic chemotherapy.
[CECORC]	_{Title :} Back Pain Outcomes Using Longitudinal Data _{Project Years :} September 2010 - September 2013 _{Principal Investigator :} Jeffrey G. Jarvik, MD, MPH		Agency for Healthcare Research and Quality	_{Clinical Topic :} Low Back Pain _{Purpose :} The overall goal of this project is to establish a sustainable and rich registry to evaluate prospectively the effectiveness, safety, and cost-effectiveness of interventions for patients over age 65 with low back pain.	Economic Evaluation Comparative Effectiveness
[PORPP] [SORCE]	_{Title :} Life Sciences Discovery Fund - SCOAP _{Project Years :} October 2010 - June 2012 _{Principal Investigator :} David Flum, MD, MPh Sean Sullivan, PhD		LSDF	_{Clinical Topic :} _{Purpose :} There is significant variation in the safety and outcomes of nearly every intervention in healthcare, but this is especially true for emerging healthcare. This variability in use and outcome represents a gap in quality and represents a significant financial burden to the healthcare system and society at large.
[SORCE]	_{Title :} Surgical Care and Outcomes Assessment Program Comparative Effectiveness Research Network (SCOAP CERTN) _{Project Years :} October 2010 - September 2013 _{Principal Investigator :} David R. Flum, MD, MPH	Alexander Clowes, MD E. Beth Devine, PhD Todd Edwards, PhD Larry Kessler, ScD Mark Meissner, MD Donald Patrick, PhD Sean Sullivan, PhD Peter Tarczy Hornoch, MD Erik Van Eaton, MD David Yanez, PhD Mehlia Yetisgen-Yildiz, PhD	AHRQ	_{Clinical Topic :} vascular medicine _{Purpose :} This project will develop infrastructure and improve the methodology for collecting prospective data from electronic medical records through SCOAP to generate new evidence on the comparative effectiveness of healthcare interventions and drive clinical quality improvement in vascular disease.	Comparative Effectiveness Patient Centered Outcomes Dissemination & Translation
[HIPRC]	_{Title :} Feasibility Study of Distracted Driving Interventions. _{Project Years :} December 2010 - November 2012 _{Principal Investigator :} Beth Ebel, MD		NIH	_{Clinical Topic :} teen driving _{Purpose :} This project is designed as a feasibility to study to plan a large-scale intervention study of interventions to reduce teen distracted driving.
[HIPRC]	_{Title :} Strengthening Injury Control Research in Ghana _{Project Years :} March 2011 - February 2016 _{Principal Investigator :} Ebel		Fogarty International Center (NIH)	_{Clinical Topic :} injury control _{Purpose :} The broad goal of this proposal is to develop a model program to strengthen the training and research capacity for injury control in Ghana.
[PORPP]	_{Title :} PEPFAR - Kiarie Yr 4 _{Project Years :} September 2011 - September 2012 _{Principal Investigator :} Michael Chung, MD Lou Garrison, PhD		University of Nairobi	_{Clinical Topic :} _{Purpose :} The University of Nairobi and the University of Washington propose to develop a HIV/AIDS Training Program that will increase Kenyan national capacity in management, health economics, and monitoring and evaluation/informatics. Guided by Kenyan national guidelines and the goals of the President’s Emergency Plan for AIDS Relief, the collaboration will develop short-courses that will train 1,000 participants over 5 years as well as mentor 12 fellows during 2-year fellowships. The University of Nairobi will lead the application and form the foundation for training and mentorship of fellows and students with its physical, administrative, and educational infrastructure in management and health economics. The University of Washington will contribute its wealth of courses and lecturers with expertise in management, informatics, and health economics by broadcasting its lectures over the internet from Seattle to a live Kenyan audience. Subcontracted by the University of Nairobi, the University of Washington will support the fellowship through the Department of Global Health, the Center for Public Health Informatics, and the Population Leadership Program. I-TECH (International Training and Education Center for HIV), which is situated in the Department of Global Health, will also help develop the curriculum for the fellowship with its significant international experience creating HIV training programs around the world. The University of Washington will establish a program in Seattle to administer and coordinate the delivery of lectures using Adobe Connect, a webcasting modality based on the internet. With this format, lectures from the UW will be conveyed to students and fellows situated in multiple sites around Kenya.
[PORPP]	_{Title :} Variations in Health _{Project Years :} September 2011 - September 2012 _{Principal Investigator :} Sean Sullivan, PhD		Merck & Co, Inc.	_{Clinical Topic :} _{Purpose :} Patients suffering from poorly controlled moderate to severe asthma have been shown to have increased healthcare utilization patterns, including more hospitalizations with longer lengths of stay, increased visits to primary care providers and emergency departments, and use of more medications, compared to patients whose asthma is well-controlled. These patterns of increased utilization lead to overall higher medical costs, as well as reduced quality of life and increased absenteeism from work or school. In this work, we will characterize patients whose asthma is well-controlled, partly controlled, and uncontrolled (defined by Global Initiative for Asthma (GINA) guidelines) in terms of asthma treatment patterns, care-seeking behavior, and costs, including direct costs of care and indirect costs such as missed days of school/work and quality of life. We will also assess patient views on how well their asthma is controlled and whether these vary by level of control according to guideline definitions.
[PORPP]	_{Title :} Comparative Effectiveness Research _{Project Years :} December 2011 - November 2014 _{Principal Investigator :} Lou Garrison, PhD Beth Devine, PhD		PhRMA Foundation	_{Clinical Topic :} CER _{Purpose :} In 2006, the Institute of Medicine (IOM) with the support from the Commonwealth Fund began a thorough appraisal of the state of evidence-based medicine and the nature of a learning health care system. The concept and term “comparative effectiveness research” (CER) has emerged out of that inquiry along with the recognition that much of current medical practice does not have a strong evidentiary base. This has led to funding for CER under the ARRA and the Patient-Centered Outcomes Research Institute (PCORI) under. And a recent IOM report has highlighted the talent shortage in CER and training needs (IOM, 2011). The answers to the questions raised by CER require rapid, high-quality, stakeholder-informed interdisciplinary research. A new cadre of researchers is needed that cannot only design and conduct innovative and pragmatic CER studies, but also implement findings from CER in a variety of complex healthcare settings. With this in mind, we are pleased to submit this proposal to address the need cited in the Request for Proposals from the Foundation of the Pharmaceutical Research and Manufacturer’s Association, specifically to “train adequate numbers of individuals capable of conducting CER and implementing the findings of such research.” While we are already training many students who will eventually become CER practitioners, this grant will motivate and support development of a more focused curriculum in CER and will incentivize doctoral students to pursue this area of specialization.
[PORPP]	_{Title :} Exome Sequending U01 _{Project Years :} December 2011 - November 2015 _{Principal Investigator :} Gail P. Jarvik, MD Dave Veenstra, PhD		NIH	_{Clinical Topic :} _{Purpose :} This program is designed to investigate aspects of using exomic data clinically, considering clinical, technical, informatics, and bioethical components. Specifically, we propose a randomized controlled trial of exome testing vs. usual care in medical genetics clinic patients indicated for colorectal cancer/polyposis (CRC) genetic testing. We will return CRC gene test results and also incidental findings that are medically actionable. We will evaluate the effectiveness of this technology and also subject reporting on their own experiences. We will consider the input of referring physicians and patients using focus groups. We will also perform gene discovery studies for subjects without identifiable CRC mutations. An important component of our work is determination of which results to return and how best to incorporate these into the medical record. These studies will facilitate the future practice of genomic medicine.
[PORPP]	_{Title :} Pacific Northwest Evidence-Based Practice Center _{Project Years :} August 2012 - June 2017 _{Principal Investigator :} Sean Sullivan	Rafael Alfonso, David Au, Anirban Basu, Thomas Benedetti, Brian Bresnahan, Alex Cahana, Josh Carlson, Randall Curtis, Patchen Dellinger, Beth Devine, David Eschenbach, Ruth Etzioni, Dave Flum, Lou Garrison, Laurie Gold, John Gore, Lurdes Inuoe, Jerry Jarvik, Wayne Katon, Larry Kessler, Scott Ramsey, Fred Rivara, Dennis Turk, Judith Turner, Jurgen Unutzer, Thomas Varghese, David Veenstra, Heidi Wirtz, Fred Wolf	AHRQ	_{Clinical Topic :} cancer, diagnostic/imaging, musculoskeletal/spine, functional limitations/disabilities, depression/dementia _{Purpose :} proj_purpose	proj_expert

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Current Research Projects

Nursing Management of IBS: Improving Outcomes

Problem Solving/Physical Interventions and Aging

Exercise & Health Promotion for MCI: A Controlled Trial

Psychosocial/Behavioral Intervention in Post Stroke Depression (PSD)

Development of a Cardiac Assessment and Tracking System (CART-CL).

Strengtening Injury Control Research in Ghana

Behavioral Treatment of Nocturnal Disturbances in AD

Injury Control Collaboration with Harborview Injury Prevention and Research Center

Dyspnea Self-Management: Internet or Face-to-Face

CAST Intervention for Reducing Adolescent Risk Behaviors

Promoting Infant Mental Health in Foster Care

Strengthening Injury Control in the Pacific Northwest

Washington State's Use of Venous Thromboembolism (VTE) Chemoprophylaxis and Rates of VTE after Abdominal Surgery

Improving Cognitive Outcome Precision & Responsiveness with modern Psychometrics

Child Safety Seat Intervention for Pacific Northwest Tribes

Data Investigation of Bariatric Surgery Outcomes and Economic Savings

Risk-Benefit Framework for Genetic Tests

SPS - Stergachis

The ACTIve intervention to Improve Hopsice Caregiver Pain management

Child Safety Seat Intervention for Pacific Northwest Tribes

English and Spanish Assessment of Cognition in Elderly

Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule

3D-CAM: Deriving and Validating a 3-minute Diagnostic Assessment for Delirium

Improving Medication Adherence for Patients with Low Functional Health Literacy: An Intervention with Talking Pill Bottles

Patient reported outcomes in routine clinical care of patients infected with HIV

Psychoeducation for Spouses of Women with Breast Cancer

Patient and Intimate Partner Intervention to Improve Outcome After an ICD

Patient Reported Outcomes in Routine Clinical Care of Patients Infected with HIV

Alzeheimer’s Disease Patient Registry (ADPR) The Adult Changes of Thought (ACT)

CER Administrative Supplement- Workforce Development (ARRA)

Comparative Effectiveness Research in Genomics and Personalized Medicine

ADVancing Innovative Comparative Effectiveness research-cancer diagnostics - ADVICE

Quality Information Resource Center.

Patient Centered Medical Home Demonstration Lab Coordinating Center.

CHGE

Surgical Disparities in American Indian/Alaska Native Populations in Lung, Breast, Prostate, and Colorectal Cancer

ARRA CHASE Training

Feasibility, Efficacy, and Mechanisms of Surgical vs. Medical Diabetes Treatment

Pharmacogenetics

Costs and Benefits of Teen Driver Intervention

ARRA BOLD CHOICE

Benefit-Risk Balance

SCOAP CER Translation Network

Comparative Effectiveness of Two Interventions for Teen Distracted Driving.

Pragmatic Trial of Colony Stimulating Factors with Intermediate Risk Chemotherapy

Back Pain Outcomes Using Longitudinal Data

Life Sciences Discovery Fund - SCOAP

Surgical Care and Outcomes Assessment Program Comparative Effectiveness Research Network (SCOAP CERTN)

Feasibility Study of Distracted Driving Interventions.

Strengthening Injury Control Research in Ghana

PEPFAR - Kiarie Yr 4

Variations in Health

Comparative Effectiveness Research

Exome Sequending U01

Pacific Northwest Evidence-Based Practice Center