Current Research Projects

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PURPOSE
CHASE CORE
[Nursing]
Title :

Nursing Management of IBS: Improving Outcomes

Project Years :

August 1996 - May 2012

Principal Investigator :

Heitkemper, Margaret

Kevin Cain; Monica Jarrett

National Institutes of Health

Clinical Topic :

irritable bowel syndrome

Purpose :

Test the effectiveness of a nutrition+probiotic therapy and a nutrition+short CBT program in patients with IBS as compared to nutrition-counseling & placebo

[Nursing]
Title :

Problem Solving/Physical Interventions and Aging

Project Years :

September 2000 - August 2011

Principal Investigator :

Teri, Linda

Eric Larson, Rebecca Logsdon, Sue McCurry

National Institutes of Health

Clinical Topic :

dementia care

Purpose :

Compare modes of intervention in dementia patients on emotional well-being and health behaviors

[Nursing]
Title :

Exercise & Health Promotion for MCI: A Controlled Trial

Project Years :

September 2000 - August 2011

Principal Investigator :

Teri, Linda

Rebeca Logsdon, Sue McCurry

National Institutes of Health

Clinical Topic :

mild cognitive impairment

Purpose :

Effectiveness of exercise versus health promotion in reducing decline in mild cognitive impairment

[Nursing]
Title :

Psychosocial/Behavioral Intervention in Post Stroke Depression (PSD)

Project Years :

July 2001 - July 2014

Principal Investigator :

Mitchell, Pamela

Kyra Becker; Kevin Cain; Catherine Kirkness, Ruth Kohen; David Tirschwell; Linda Teri; Richard Veith

National Institutes of Health

Clinical Topic :

depression after stroke

Purpose :

Compare effectiveness of in-person versus telephone delivery of brief psychosocial intervention in depression after stroke

[VA HSR&D]
Title :

Development of a Cardiac Assessment and Tracking System (CART-CL).

Project Years :

January 2003 - December 2010

Principal Investigator :

Stephan Fihn, MD, MPH

VA Patient Care Services

Clinical Topic :

invasive cardiac procedures

Purpose :

The Cardiac Assessment Reporting and Tracking System – Cath Lab (CART-CL) is a third party software package under development by medical center staff in Seattle and Denver. It is a collaborative effort among Patient Care Services, Office of Information, Office of Quality and Performance, and the Ischemic Heart Disease Quality Enhancement Research Initiative (IHD-QuERI)

[HIPRC]
Title :

Strengtening Injury Control Research in Ghana

Project Years :

June 2005 - February 2011

Principal Investigator :

Beth Ebel, MD

Fogarty International Center (NIH)

Clinical Topic :

injury control
surveillance
prevention
treatment

Purpose :

The broad goal of this proposal is to develop a model program to strengthen the training and research capacity for injury control in Ghana. The program will educate a cadre of outstanding scientists and professionals in cutting edge research methods and training techniques. This will facilitate the development of successful and sustainable research and training activities across the spectrum of injury control, including surveillance, prevention, and treatment.

[Nursing]
Title :

Behavioral Treatment of Nocturnal Disturbances in AD

Project Years :

August 2005 - July 2011

Principal Investigator :

McCurry, Susan

Linda Teri; Michael Vitiello

National Institutes of Health

Clinical Topic :

Alzheimer's

Purpose :

Compare effectiveness of 4 modes of intervention for Alzheimer's patient with nightime disturbances

[HIPRC]
Title :

Injury Control Collaboration with Harborview Injury Prevention and Research Center

Project Years :

January 2006 - January 2011

Principal Investigator :

Beth Ebel, MD

National Highway Traffic Safety Administration

Clinical Topic :

Injury Prevention

Purpose :

[Nursing]
Title :

Dyspnea Self-Management: Internet or Face-to-Face

Project Years :

March 2006 - May 2011

Principal Investigator :

Nguyen, Huong

Joshua Benditt; Seth Wolpin

University of California

Clinical Topic :

dyspnea

Purpose :

Effectiveness of internet dyspnea self-management versus face to face or attention control

[Nursing]
Title :

CAST Intervention for Reducing Adolescent Risk Behaviors

Project Years :

June 2006 - March 2011

Principal Investigator :

Thompson, Frances

Carole Hooven

National Institutes of Health

Clinical Topic :

Adolescent risk behavior

Purpose :

Compare effectiveness of school-based programs on adolescent risk behaviors

[Nursing]
Title :

Promoting Infant Mental Health in Foster Care

Project Years :

September 2006 - August 2011

Principal Investigator :

Spieker, Susan

Jean Kelly, Maureen Marcenko, Monica Oxford

National Institutes of Health

Clinical Topic :

Infant mental health

Purpose :

Evaluate effectiveness of community developed attachment intervention in foster care

[HIPRC]
Title :

Strengthening Injury Control in the Pacific Northwest

Project Years :

September 2006 - September 2011

Principal Investigator :

Beth Ebel, MD

National Highway Traffic Safety Administration

Clinical Topic :

injury prevention

Purpose :

This five-year cooperative agreement supports injury prevention activities in occupant and transportation safety in the Northwest Region, and will support graduate student research in areas of mutual interest.

  • Health System Evaluation
[SORCE]
Title :

Washington State's Use of Venous Thromboembolism (VTE) Chemoprophylaxis and Rates of VTE after Abdominal Surgery

Project Years :

January 2007 - December 2010

Principal Investigator :

David R. Flum, MD

Foundation for Health Care Quality

Sanofi-Aventis

Clinical Topic :

Surgery

Purpose :

The purpose of this grant is to evaluate Washington State’s use of venous thromboembolism (VTE) chemoprophylaxsis, rates of VTE after abdominal surgery, and the changes in the natural history of VTE

[CECORC]
Title :

Improving Cognitive Outcome Precision & Responsiveness with modern Psychometrics

Project Years :

September 2007 - August 2012

Principal Investigator :

Crane

National Institute on Aging

Clinical Topic :

Alzheimer’s disease, cognition, neuroimaging

Purpose :

This R01 seeks to analyze data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a large study with serial neuroimaging from a carefully selected cohort of 811 elderly individuals. In addition to neuroimaging data, ADNI also collected an extensive neuropsychological battery at each time point. In this project we use tools of modern psychometrics to develop psychometrically sophisticated composite scores to use in analyses.

  • Patient Centered Outcomes
  • Technology Assessment
[HIPRC]
Title :

Child Safety Seat Intervention for Pacific Northwest Tribes

Project Years :

January 2008 - January 2013

Principal Investigator :

Beth Ebel, MD

NCMHD

Clinical Topic :

Injury Prevention

Purpose :

[PORPP]
[SORCE]
Title :

Data Investigation of Bariatric Surgery Outcomes and Economic Savings

Project Years :

January 2008 - September 2011

Principal Investigator :

David R. Flum, MD; Sean Sullivan PhD

Andrew Wright, MD; Lou Garrison, PhD; David Arterburn, MD, MPH;

DOD

Clinical Topic :

Obesity; Surgery

Purpose :

The goal of this project is to use collected data and modeling techniques to create a portfolio of research on the economics of obesity and its treatments

[PORPP]
Title :

Risk-Benefit Framework for Genetic Tests

Project Years :

January 2008 - September 2012

Principal Investigator :

David Veenstra, PhD

CDC

Clinical Topic :

Genetic Testing

Purpose :

This project will develop a systematic, quantitative approach for assessing clinical risks and benefits of genetic tests, using a consensus development process with multiple stakeholders.

[PORPP]
Title :

SPS - Stergachis

Project Years :

April 2008 - March 2012

Principal Investigator :

Andy Stergachis, PhD Lou Garrison, PhD

Management Sciences for Health

Clinical Topic :

Pharmacy; medicine; drugs

Purpose :

The purpose of this proposal is to build institutional and individual capacity within developing countries to effectively and efficiently manage pharmaceutical systems, protect public health through improved governance in the pharmaceutical sector, and enable the increased use and successful implementation of population, health and nutrition priority services by improving the availability and use of medicines of assured quality.

[Nursing]
Title :

The ACTIve intervention to Improve Hopsice Caregiver Pain management

Project Years :

May 2008 - April 2011

Principal Investigator :

Demiris, George

Ardith Doorenbos

National Institutes of Health

Clinical Topic :

hospice care

Purpose :

Effectiveness of videophone in hospice intervention; compare costs of in-person vs videophone

[HIPRC]
Title :

Child Safety Seat Intervention for Pacific Northwest Tribes

Project Years :

May 2008 - January 2013

Principal Investigator :

Beth Ebel, MD

NCMHD

Clinical Topic :

child safety

Purpose :

Using a community based participatory research model, we propose to plan, implement, and evaluate child safety interventions in 6 Northwestern tribal communities in a case-crossover design. We anticipate that well designed, tribe-implemented programs will eliminate barriers, increase proper child restraint through a participatory, community-based intervention.

[CECORC]
Title :

English and Spanish Assessment of Cognition in Elderly

Project Years :

August 2008 - May 2013

Principal Investigator :

Mungas

Crane

National Institute on Aging

Clinical Topic :

Neuropsychology, cognitive assessment

Purpose :

The SENAS (Spanish and English Neuropsychological Assessment Scales) have been developed over the past several cycles of this grant. This cycle the focus turns to bias assessment, specifically differential item functioning (DIF).

  • Patient Centered Outcomes
[CECORC]
Title :

Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule

Project Years :

September 2008 - July 2012

Principal Investigator :

Jeffrey G. Jarvik, MD, MPH

Oregon Health & Science University

Clinical Topic :

Spinal Stenosis

Purpose :

To examine spine surgery rates for spinal stenosis among the elderly in the United States and whether they continue to rise, and if the introduction of interbody fusion cages results in acceleration of surgery rates; to examine whether or not re-operation rates are increasing over time; to determine if certain surgical procedures are associated with unusually high rates of re-operations; to document the trends for ambulatory disc surgery to replace inpatient disc surgery.

  • Comparative Effectiveness
[CECORC]
Title :

3D-CAM: Deriving and Validating a 3-minute Diagnostic Assessment for Delirium

Project Years :

September 2008 - June 2012

Principal Investigator :

Marcantonio

Crane

National Institute on Aging

Clinical Topic :

Delirium

Purpose :

This study seeks to develop a 3-minute tool for identifying delirium in hospitalized patients.

  • Patient Centered Outcomes
[Nursing]
Title :

Improving Medication Adherence for Patients with Low Functional Health Literacy: An Intervention with Talking Pill Bottles

Project Years :

September 2008 - July 2011

Principal Investigator :

Wolpin, Seth

Donna Berry, Ann Kurth, Annie Lam, William Lober

National Institutes of Health

Clinical Topic :

medication adherence

Purpose :

Compare technologies for enhancing medication adherence in low literacy

[SeaQoL]
Title :

Patient reported outcomes in routine clinical care of patients infected with HIV

Project Years :

January 2009 - January 2013

Principal Investigator :

Donald L. Patrick, PhD, MSPH, Heidi M. Crane, MD, MPH, Paul K. Crane, MD, MPH

Todd Edwards, PhD, Ed Wagner, MD, MPH, Leo Morales, MD, PhD, Laura Gibbons, PhD, Mari Kitahata, MD, MPH, Rosa Solario, MD, MPH, Judith Shaefer, MPH, Ann Collier, MD, James Ralston, MD, MPH,Michael Mugavero, MD, Erika Austin, PhD, Michael Saag, MD, Joseph Schumacher, PhD, James Willig, MD, Donna Porter, PhD

NIAMS

Clinical Topic :

HIV; Depression; Physical Health

Purpose :

Integrate PRO Measurement Information System (PROMIS) data with other data captured during clinical care of Spanish- and English-speaking patients infected with HIV and improve medical care processes and patient outcomes in clinical practice settings

[Nursing]
Title :

Psychoeducation for Spouses of Women with Breast Cancer

Project Years :

May 2009 - April 2011

Principal Investigator :

Lewis, Frances

Kristen Fletcher; Mary Shands; Ellen Zahlis

National Institutes of Health

Clinical Topic :

psychosocial aspects of cancer

Purpose :

Compare modes of delivery of couples therapy on reduction of psychosocial morbidity, increase psychosocial functioning, and enhance the quality of life of women and spouses affected by breast cancer

[Nursing]
Title :

Patient and Intimate Partner Intervention to Improve Outcome After an ICD

Project Years :

July 2009 - June 2014

Principal Investigator :

Dougherty, Cynthia

Peter Kudenchuk; Frances Thompson

National Institutes of Health

Clinical Topic :

Arrythmia

Purpose :

This research project will test the outcomes of an intervention designed to enable patient/family participation in interdisciplinary teams (IDTs) through use of a commercially available videophone

[CECORC]
Title :

Patient Reported Outcomes in Routine Clinical Care of Patients Infected with HIV

Project Years :

September 2009 - July 2013

Principal Investigator :

Heidi Crane, Paul Crane & Donald Patrick

NIAMSD

Clinical Topic :

HIV, patient reported data, quality of life

Purpose :

This U01 is part of the PROMIS initiative – Patient Reported Outcomes Measurement Information System. PROMIS is a large multi-site Roadmap Initiative with 12 PROMIS Research Sites and 3 Coordinating Centers. The UW project is situated in clinical care settings in the CNICS (CFAR Network of Integrated Clinical Systems, where CFAR stands for Centers For AIDS Research) Network of 9 HIV clinics across the US. We are evaluating several established PROMIS domains as well as developing a new one, and working closely with clinicians and patients to integrate collection and reporting of patient reported data in real time at the point of care.

  • Patient Centered Outcomes
  • Comparative Effectiveness
[CECORC]
Title :

Alzeheimer’s Disease Patient Registry (ADPR) The Adult Changes of Thought (ACT)

Project Years :

September 2009 - August 2014

Principal Investigator :

Larson

Crane

National Institute on Aging

Clinical Topic :

Alzheimer’s disease

Purpose :

The ACT study comprises a prospective cohort study of some 4400 elderly Group Health members to date. Participants are dementia free at baseline and evaluated with cognitive testing every two years. The study started in 1994 and has had continuous funding since. The study has amassed a wealth of data on participants. Specific aims this cycle focus on four brain outcomes: dementia and AD, cognitive decline, neuropathological outcomes from fixed tissues, and neuropathological outcomes from frozen brain tissues. The study has completed 400 autopsies. A systematic chart review effort is underway to collect about 150 medical conditions from paper charts that extend back an average of 30 years prior to ACT study entry. Genome wide SNPs are available for much of the cohort and efforts are underway to expand those numbers. This cycle’s specific aims focus on hyperglycemia and insulin resistance, atrial fibrillation and anticoagulation, renal functioning, and relationships between physical performance, frailty, and brain outcomes.

  • Patient Centered Outcomes
  • Comparative Effectiveness
[HSERV]
[PORPP]
Title :

CER Administrative Supplement- Workforce Development (ARRA)

Project Years :

September 2009 - September 2012

Principal Investigator :

Disis, Mary

Sean Sullivan, PhD; Larry Kessler, ScD; Pam Mitchell, PhD

National Center for Research Resources

Clinical Topic :

Comparative Effectiveness Research (CER)

Purpose :

The specific aims for this project are: 1) Develop, implement and evaluate a state-of-the-art
CER lecture series (ie. grand rounds) 2). Develop
curriculum and hands-on training activities for a weeklong summer Symposposim for CER education designed to educate clinical and translational scientists at all levels of career development,
including train-the-trainer component to promote dissemination and adoption of CER in our partner
communities, and 3) Disseminate the educational materials broadly in the form of a web-based
electronic toolkit

[PORPP]
Title :

Comparative Effectiveness Research in Genomics and Personalized Medicine

Project Years :

September 2009 - August 2012

Principal Investigator :

David Veenstra, PhD

Lou Garrison, PhD

Center for Comparative Effectiveness Research in Cancer Genomics – CANCERGEN

Clinical Topic :

Cancer; Genomics

Purpose :

Evaluation of the clinical and economic outcomes of genomic test.

[HSERV]
[PORPP]
Title :

ADVancing Innovative Comparative Effectiveness research-cancer diagnostics - ADVICE

Project Years :

October 2009 - August 2012

Principal Investigator :

Larry Kessler ScD; Sean Sullivan PhD

Scott Ramsey, MD

NCI

Clinical Topic :

Cancer

Purpose :

Establish a resource for CER on cancer diagnostics using multiple existing data sources

[VA HSR&D]
Title :

Quality Information Resource Center.

Project Years :

October 2009 - September 2010

Principal Investigator :

Stephan Fihn, MD, MPH

VA Patient Care Services

Clinical Topic :

risk models

Purpose :

Goal is to build predictive risk models that will be used to classify patients into clinically relevant risk categories for case management.

[VA HSR&D]
Title :

Patient Centered Medical Home Demonstration Lab Coordinating Center.

Project Years :

April 2010 - March 2012

Principal Investigator :

Stephan Fihn, MD, MPH

VA Patient Care Services

Clinical Topic :

Patient Centered Medical Home (PCMH) Demonstration Laboratories

Purpose :

To facilitate the work of the Patient Centered Medical Home (PCMH) Demonstration Laboratories, the Primary Care Program Office has decided to designate the oversight of the five Laboratories to a Coordinating Center.

[PORPP]
Title :

CHGE

Project Years :

April 2010 - March 2015

Principal Investigator :

Wylie Burke, MD Lou Garrison, PhD Dave Veenstra, PhD

NIH/NHGRI

Clinical Topic :

Purpose :

proj_purpose

  • proj_expert
[SORCE]
Title :

Surgical Disparities in American Indian/Alaska Native Populations in Lung, Breast, Prostate, and Colorectal Cancer

Project Years :

May 2010 - April 2014

Principal Investigator :

David R. Flum, MD, MPH

Tom Varghese, MD, MSc; Sara Javid, MD; Mike Porter, MD, MPH; Lori Arviso Alvord, MD; Ardith Doorenboos, RN, PhD; Arden Morris, MD, MPH

NCI

Clinical Topic :

Cancer; Surgery

Purpose :

A project as part of a population health center grant, this project examine influences ranging from organizational to individual factors on outcomes among AI/ANs undergoing surgery for the most common cancers

[PORPP]
Title :

ARRA CHASE Training

Project Years :

June 2010 - June 2013

Principal Investigator :

Sean Sullivan, PhD Dave Veenstra, PhD

AHRQ

Clinical Topic :

Purpose :

The issues facing healthcare systems in the United States today are complex and raise questions as to whether we are generating and utilizing evidence of the relative benefits and harms of medical interventions wisely to improve health across the population. The answers to these questions require sophisticated, interdisciplinary research. A new cadre of researchers is needed that can not only design and conduct innovative and pragmatic comparative effectiveness research (CER) studies, but also implement findings from CER in a variety of complex healthcare settings. Comparative effectiveness research is the conduct and synthesis of research comparing alternative interventions designed to diagnose, treat and monitor health conditions in “real world” settings. The purpose of CER is to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision-makers about which interventions are most effective for which patients under specific circumstances. An important aspect of CER is responding to priority areas for stakeholders with targeted and timely research intended to inform decision-making. In response to this K12 FOA, we plan to provide intensive, supervised research and methodology training in order to foster scientists able to undertake comparative effectiveness research.

[SORCE]
Title :

Feasibility, Efficacy, and Mechanisms of Surgical vs. Medical Diabetes Treatment

Project Years :

July 2010 - June 2013

Principal Investigator :

David R. Flum, MD, MPH; David E. Cummings, MD

Mario Kratz, PhD; Karen Foster Schubert, MD; David Arterburn, MD, MPH

NIDDK

Clinical Topic :

Diabetes; Surgery

Purpose :

Identify and overcome barriers to execute a randomized clinical trial in the USA of gastric bypass surgery vs. an optimal medical/lifestyle intervention to treat type 2 diabetes mellitus in patients with a BMI of 30-40 kg/m2.

[PORPP]
Title :

Pharmacogenetics

Project Years :

July 2010 - June 2015

Principal Investigator :

Ken Thummel, PhD Dave Veenstra, PhD

NIGMS

Clinical Topic :

Purpose :

Genetic testing offers the opportunity to identify sources of inter-individual variability in drug disposition and

response, with the goal of individualizing therapy (drug selection and dose) and improving patient and public
health outcomes. A small number of pharmacogenetic tests are already in clinical use, and other promising examples are emerging, including tests to improve the safety of warfarin, tamoxifen and tacrolimus therapy. Despite this promise, most studies have been undertaken in resource-intensive, tertiary care centers and their relevance for rural health care practice is unknown. Information gaps are especially notable for Alaska Native and American Indian (AN/AI) communities living in rural locations; addressing these gaps requires attention to scientific, health service and cultural issues. With these uncertainties and knowledge gaps in mind, we propose to create a new Center on Pharmacogenetics in Rural and Underserved Populations. This Center will work in partnership with indigenous communities in Anchorage and the Yukon-Kuskowkim Delta in Alaska and on the Flathead Reservation in Montana, and with rural providers in these locations and in rural Washington, to ensure that there is adequate community understanding, biological knowledge, and medical infrastructure to respond appropriately to national recommendations or mandates related to pharmacogenetics. Our Center will utilize community-based participatory research methods to evaluate community and clinical perspectives on pharmacogenetics; pursue foundational research in AN/AI and rural communities related to genetic variation and response to warfarin, tamoxifen and tacrolimus therapy; evaluate gene-environment interactions related to coagulation factors in one indigenous community; and lay the groundwork for a research infrastructure linking rural practices to pharmacogenetics researchers.

[HIPRC]
Title :

Costs and Benefits of Teen Driver Intervention

Project Years :

July 2010 - June 2015

Principal Investigator :

Beth Ebel, MD

NIH

Clinical Topic :

crash and injury among teen drivers

Purpose :

The project goal is to study the costs and benefits of in-vehicle monitored driving for new teen drivers. T

[PORPP]
Title :

ARRA BOLD CHOICE

Project Years :

July 2010 - September 2013

Principal Investigator :

Gail P. Jarvik, MD Sean Sullivan, PhD

AHRQ

Clinical Topic :

Purpose :

The overall goal of this project is to establish a sustainable and rich registry to evaluate prospectively the effectiveness, safety, and cost-effectiveness of interventions for patients over age 65 with low back pain.

[PORPP]
Title :

Benefit-Risk Balance

Project Years :

August 2010 - August 2012

Principal Investigator :

Lou Garrison, PhD

Amylin Pharmaceuticals, Inc.

Clinical Topic :

Cancer

Purpose :

Exenatide—both twice daily and once weekly--have well established clinical benefit. Two concerns about the potential risks (or harms) at this point are for pancreatitis and thyroid cancer. Given the rarity of events, detecting any signals against background noise is a challenge for epidemiologists and pharmacovigilance experts. However, a health outcomes model can help assess whether the risks should be a concern as compared to benefits.

[PORPP]
[SORCE]
Title :

SCOAP CER Translation Network

Project Years :

September 2010 - September 2013

Principal Investigator :

David Flum, MD, MPH Sean Sullivan, PhD

AHRQ

Clinical Topic :

Purpose :

The state of Washington has in place a regional health information organization (RHIO) that collects patient level clinical data in the context of the surgical setting – the Surgical Care and Outcomes Assessment Program (SCOAP). Currently, centers contribute data to SCOAP through manual abstraction. The first aim of this grant is to connect each of these disparate electronic health records, creating a common data platform using Microsoft’s Amalga Unified Intelligence SystemTM (Amalga UISTM), thereby creating the E-HOAP CER Network. The second aim is to demonstrate the usability of the E-HOAP network by conducting a comparative study of treating peripheral vascular disease with stents versus surgery.

[HIPRC]
Title :

Comparative Effectiveness of Two Interventions for Teen Distracted Driving.

Project Years :

September 2010 - August 2012

Principal Investigator :

Beth Ebel, MD

CDC

Clinical Topic :

Teen driving

Purpose :

The project proposes to measure the comparative effectiveness of several in-vehicle technologies aiming to reduce teen distracted driving.

[PORPP]
Title :

Pragmatic Trial of Colony Stimulating Factors with Intermediate Risk Chemotherapy

Project Years :

September 2010 - August 2013

Principal Investigator :

Scott Ramsey, MD

Sean D. Sullivan, PhD

AHRQ

Clinical Topic :

cancer; chemotherapy treatment

Purpose :

This pragmatic clinical trial will compare the clinical and economic effectiveness of a guideline-informed, protocol-based intervention for prescribing primary prophylactic colony stimulating factors (CSFs) with usual care in patients with breast, non-small cell lung, or colorectal cancer receiving their first course of neoadjuvant, adjuvant, or palliative cytotoxic chemotherapy.

[CECORC]
Title :

Back Pain Outcomes Using Longitudinal Data

Project Years :

September 2010 - September 2013

Principal Investigator :

Jeffrey G. Jarvik, MD, MPH

Agency for Healthcare Research and Quality

Clinical Topic :

Low Back Pain

Purpose :

The overall goal of this project is to establish a sustainable and rich registry to evaluate prospectively the effectiveness, safety, and cost-effectiveness of interventions for patients over age 65 with low back pain.

  • Economic Evaluation
  • Comparative Effectiveness
[PORPP]
[SORCE]
Title :

Life Sciences Discovery Fund - SCOAP

Project Years :

October 2010 - June 2012

Principal Investigator :

David Flum, MD, MPh Sean Sullivan, PhD

LSDF

Clinical Topic :

Purpose :

There is significant variation in the safety and outcomes of nearly every intervention in healthcare, but this is especially true for emerging healthcare. This variability in use and outcome represents a gap in quality and represents a significant financial burden to the healthcare system and society at large.

[SORCE]
Title :

Surgical Care and Outcomes Assessment Program Comparative Effectiveness Research Network (SCOAP CERTN)

Project Years :

October 2010 - September 2013

Principal Investigator :

David R. Flum, MD, MPH

Alexander Clowes, MD E. Beth Devine, PhD Todd Edwards, PhD Larry Kessler, ScD Mark Meissner, MD Donald Patrick,
PhD Sean Sullivan, PhD Peter Tarczy Hornoch, MD Erik Van Eaton, MD David Yanez, PhD Mehlia Yetisgen-Yildiz, PhD

AHRQ

Clinical Topic :

vascular medicine

Purpose :

This project will develop infrastructure and improve the methodology for collecting prospective data from electronic
medical records through SCOAP to generate new evidence on the comparative effectiveness of healthcare interventions
and drive clinical quality improvement in vascular disease.

  • Comparative Effectiveness
  • Patient Centered Outcomes
  • Dissemination & Translation
[HIPRC]
Title :

Feasibility Study of Distracted Driving Interventions.

Project Years :

December 2010 - November 2012

Principal Investigator :

Beth Ebel, MD

NIH

Clinical Topic :

teen driving

Purpose :

This project is designed as a feasibility to study to plan a large-scale intervention study of interventions to reduce teen distracted driving.

[HIPRC]
Title :

Strengthening Injury Control Research in Ghana

Project Years :

March 2011 - February 2016

Principal Investigator :

Ebel

Fogarty International Center (NIH)

Clinical Topic :

injury control

Purpose :

The broad goal of this proposal is to develop a model program to strengthen the training and research capacity for injury control in Ghana.

[PORPP]
Title :

PEPFAR - Kiarie Yr 4

Project Years :

September 2011 - September 2012

Principal Investigator :

Michael Chung, MD Lou Garrison, PhD

University of Nairobi

Clinical Topic :

Purpose :

The University of Nairobi and the University of Washington propose to develop a HIV/AIDS Training Program
that will increase Kenyan national capacity in management, health economics, and monitoring and evaluation/informatics. Guided by Kenyan national guidelines and the goals of the President’s Emergency Plan for AIDS Relief, the collaboration will develop short-courses that will train 1,000 participants over 5 years as well as mentor 12 fellows during 2-year fellowships. The University of Nairobi will lead the application and form the foundation for training and mentorship of fellows and students with its physical, administrative, and educational infrastructure in management and health economics. The University of Washington will contribute its wealth of courses and lecturers with expertise in management, informatics, and health economics by broadcasting its lectures over the internet from Seattle to a live Kenyan audience. Subcontracted by the University of Nairobi, the University of Washington will support the fellowship through the Department of Global Health, the Center for Public Health Informatics, and the Population Leadership Program. I-TECH (International Training and Education Center for HIV), which is situated in the Department of Global Health, will also help develop the curriculum for the fellowship with its significant international experience creating HIV training programs around the world. The University of Washington will establish a program in Seattle to administer and coordinate the delivery of lectures using Adobe Connect, a webcasting modality based on the internet. With this format, lectures from the UW will be conveyed to students and fellows situated in multiple sites around Kenya.

[PORPP]
Title :

Variations in Health

Project Years :

September 2011 - September 2012

Principal Investigator :

Sean Sullivan, PhD

Merck & Co, Inc.

Clinical Topic :

Purpose :

Patients suffering from poorly controlled moderate to severe asthma have been shown to have increased healthcare utilization patterns, including more hospitalizations with longer lengths of stay, increased visits to primary care providers and emergency departments, and use of more medications, compared to patients whose asthma is well-controlled. These patterns of increased utilization lead to overall higher medical costs, as well as reduced quality of life and increased absenteeism from work or school. In this work, we will characterize patients whose asthma is well-controlled, partly controlled, and uncontrolled (defined by Global Initiative for Asthma (GINA) guidelines) in terms of asthma treatment patterns, care-seeking behavior, and costs, including direct costs of care and indirect costs such as missed days of school/work and quality of life. We will also assess patient views on how well their asthma is controlled and whether these vary by level of control according to guideline definitions.

[PORPP]
Title :

Comparative Effectiveness Research

Project Years :

December 2011 - November 2014

Principal Investigator :

Lou Garrison, PhD Beth Devine, PhD

PhRMA Foundation

Clinical Topic :

CER

Purpose :

In 2006, the Institute of Medicine (IOM) with the support from the Commonwealth Fund began a thorough appraisal of the state of evidence-based medicine and the nature of a learning health care system. The concept and term “comparative effectiveness research” (CER) has emerged out of that inquiry along with the recognition that much of current medical practice does not have a strong evidentiary base. This has led to funding for CER under the ARRA and the Patient-Centered Outcomes Research Institute (PCORI) under. And a recent IOM report has highlighted the talent shortage in CER and training needs (IOM, 2011). The answers to the questions raised by CER require rapid, high-quality, stakeholder-informed interdisciplinary research. A new cadre of researchers is needed that cannot only design and conduct innovative and pragmatic CER studies, but also implement findings from CER in a variety of complex healthcare settings. With this in mind, we are pleased to submit this proposal to address the need cited in the Request for Proposals from the Foundation of the Pharmaceutical Research and Manufacturer’s Association, specifically to “train adequate numbers of individuals capable of conducting CER and implementing the findings of such research.” While we are already training many students who will eventually become CER practitioners, this grant will motivate and support development of a more focused curriculum in CER and will incentivize doctoral students to pursue this area of specialization.

[PORPP]
Title :

Exome Sequending U01

Project Years :

December 2011 - November 2015

Principal Investigator :

Gail P. Jarvik, MD Dave Veenstra, PhD

NIH

Clinical Topic :

Purpose :

This program is designed to investigate aspects of using exomic data clinically, considering clinical, technical, informatics, and bioethical components. Specifically, we propose a randomized controlled trial of exome testing vs. usual care in medical genetics clinic patients indicated for colorectal cancer/polyposis (CRC) genetic testing. We will return CRC gene test results and also incidental findings that are medically actionable. We will evaluate the effectiveness of this technology and also subject reporting on their own experiences. We will consider the input of referring physicians and patients using focus groups. We will also perform gene discovery studies for subjects without identifiable CRC mutations. An important component of our work is determination of which results to return and how best to incorporate these into the medical record. These studies will facilitate the future practice of genomic medicine.

[PORPP]
Title :

Pacific Northwest Evidence-Based Practice Center

Project Years :

August 2012 - June 2017

Principal Investigator :

Sean Sullivan

Rafael Alfonso, David Au, Anirban Basu, Thomas Benedetti, Brian Bresnahan, Alex Cahana, Josh Carlson, Randall Curtis, Patchen Dellinger, Beth Devine, David Eschenbach, Ruth Etzioni, Dave Flum, Lou Garrison, Laurie Gold, John Gore, Lurdes Inuoe, Jerry Jarvik, Wayne Katon, Larry Kessler, Scott Ramsey, Fred Rivara, Dennis Turk, Judith Turner, Jurgen Unutzer, Thomas Varghese, David Veenstra, Heidi Wirtz, Fred Wolf

AHRQ

Clinical Topic :

cancer, diagnostic/imaging, musculoskeletal/spine, functional limitations/disabilities, depression/dementia

Purpose :

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