Genetic Susceptibility

Lucio G. Costa, Study Director
Clem Furlong
Toby Cole

The overall aim of this study is to investigate the developmental neurotoxicity of two of the most commonly used organophosphates: chlorpyrifos and diazinon. We will also determine the role of genetic variability in the polymorphic serum enzyme paraoxonase (PON1) in protecting against developmental neurotoxicity.

You can download a poster to read more detailed information about this research.

Photo Close-up of handpicked apple in Yakima Valley, WA—Doug Wilson, USDA.
Specific Aims
  • Acute toxicity/dose finding by establishing a dosage regimen, determining the acetylcholinesterase (AChE) inhibition associated with these dosages, and investigating the relative contributions of chronic low-level exposure and single-dose exposures to AChE inhibition.
  • Investigate the developmental neurotoxicity of chlorpyrifos following chronic postnatal exposure.
  • Investigate the developmental neurotoxicity of diazinon following postnatal exposure.
  • Compare the developmental neurotoxicity of chlorpyrifos and diazinon to directly assess the similarities and differences in toxicity that are associated with exposure to these two related compounds, and the involvement of the Q192R polymorphism in modulating sensitivity to these effects.
For more information about the work of the Paraoxonase Polymorphisms study, please see our Publications page or contact the study director, Dr. Lucio G. Costa.

You can also learn more about the impact of our work by downloading a copy of our report "Research into Action."