Lucio G. Costa, Study Director
Clem Furlong, Investigator
The general aim of this study is to determine the role of the enzyme paraoxonase (PON1) in the developmental toxicity and neurotoxicity of organophosphorus (OP) insecticides.
Paraoxonase Polymorphisms
Specific Aims
- To investigate the acute toxicity of a number of OPs in wild type and PON1 knockout mice.
- To investigate whether human PON1, either the Arg192 or Gln192 isozyme, would offer protection against the toxicity of OPs in PON1-/- mice.
- To determine the acute toxicity of OPs in developing mice.
- To assess the developmental neurotoxicity of OPs in wild type and PON1 knockout mice.
- To determine PON1 status in infants and children.
For more information about the work of the Paraoxonase Polymorphisms study, please see our Publications page or contact the study director, Dr. Lucio G. Costa.
You can also learn more about the impact of our work by downloading a copy of our report "Research into Action."
Photo Close-up of handpicked apple in Yakima Valley, WA—Doug Wilson, USDA.
