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Center on Human Development and Disability
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Animal Behavior Core (ABC)

Animal Behavior Core images

Dr.Burbacher Thomas M. Burbacher, Ph.D., Director, tmb@uw.edu

 

Overview

The overall objective of the Animal Behavior Core (ABC) is to provide Research Affiliates with the infrastructure needed to perform the most advanced and innovative functional outcome measures when assessing the effectiveness of intrinsic (gene-based) and/or extrinsic (surgical, drug-based) interventions in animal models of neurodevelopmental disorders. The ABC provides multi-pronged services for Research Affiliates using preclinical animal models of developmental disorders. Investigators are involved integrally in both the design and conduct of the experiments. Services assist investigators in delineating the relationships between specific genetic conditions, environmental, chemical, or pharmacologic exposures or anatomical lesions and their behavioral sequelae and provide critical data for preclinical intervention trials to assess novel therapeutic targets. The core includes specialized equipment and protocols for evaluating the behavior of both mice and rats. In collaboration with the Center for Integrative Brain Research (CIBR) at Seattle Children’s Research Institute, additional rodent behavior equipment and protocols for Research Affiliates are available. Consultation services on state-of-the-art circuit mapping protocols for evaluating cells and circuits that regulate behavior are also available through the CIBR collaboration. Finally, consultation services for non-human primate models of IDD are available through our collaboration with the Washington National Primate Research Center.

Core Services

Specific services are as follows:

  1. To provide scientific, management, and budgeting services to Research Affiliates using animal models for studies of IDD;
  2. To provide behavioral testing equipment, research space, and novel testing protocols for investigators that enable state-of-the-art assessment of behavior in rodent models of IDD;
  3. To train Research Affiliates and their staff in appropriate testing protocols;
  4. To coordinate services across other IDDRC Cores and support development of clinical applications;and
  5. To promote the development of additional innovative techniques that can be utilized in conjunction with assessments of behavioral functions in rodent models of IDD.

To optimally support these objectives, the ABC is organized into 4 service components:

Mouse Behavior Laboratory (MBL)

Rat Behavior Laboratory (RBL)

Circuit Mapping Consultation (CMC)

Non-Human Primate Consultation (NPC)

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University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@uw.edu