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Center on Human Development and Disability
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developmental neuroscience

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Brain Imaging Core

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CHDD Research Domain:
Developmental Neuroscience

Developmental neuroscience—the study of how the developing brain functions—is critical to preventing and ameliorating intellectual and other developmental disabilities. CHDD research affiliates collaborate on investigations of the brain that range from the molecular and cellular level to the systems level, where behavioral significance can be assessed.

Key developmental processes such as the genesis of neurons and their migration and differentiation are being studied to better understand normal brain function and development and during neurodegenerative processes. This research is integrated with studies of a variety of developmental disorders such as brain trauma and injury, hypoxia and ischemia, epilepsy, HIV, tumors and autism.

Investigations of genetic factors in brain development provide insight into neuropathological processes that can occur during development and during neurodegenerative processes. Studies focused on brain cell structure and interaction are uncovering mechanisms by which cells recognize each other, establish synaptic contacts and evolve plastic synaptic function, an important aspect of understanding the immature brain's response to insult. Another area of investigation is aimed at elucidating factors that influence neuronal activity and cell death, including genetic mechanisms, behavioral experiences, glial cell functions and conditions in the extracellular environment of the brain.

State-of-the-art imaging techniques are an important part of CHDD's neuroscience research program. New techniques for cellular-level imaging permit assessment of functional changes without interference in the function of tissues being studied. At the systems level, CHDD investigators are using magnetic resonance imaging and magnetic resonance spectroscopy to investigate anatomical and functional changes in the brain associated with various developmental disorders, including fetal alcohol syndrome, epilepsy, hearing-impairment, autism and learning disabilities.

Investigators:


Elizabeth Aylward, Ph.D.
Seattle Children's Research Institute
Nigel Bamford, M.D.
206-616-4150
Neurology, Pediatrics
Olivia Bermingham-McDonogh, Ph.D.
206-616-4652
Biological Structure
Donald Born, M.D., Ph.D.
206-543-8769
Pathology
Eliot Brenowitz, Ph.D.
206-543-8534
Psychology and Biology
Mark Bothwell, Ph.D.
206-543-7924
Physiology and Biophysics
William Catterall, Ph.D.
206-543-1925
Pharmacology
Lucio Costa, Ph.D.
206-543-2831
Environmental and Occupational Health Sciences
Stephen Dager, M.D.
206-616-1558
Psychiatry and Behavioral Sciences
Raimondo D'Ambrosio, Ph.D.
206-897-4710
Psychiatry and Behavioral Sciences
Gwenn Garden, M.D., Ph.D.
206-616-9402
Neurology
Adam Geballe, M.D.
206-667-5122
Medicine
Christine Gleason, M.D.
206-543-3200
Pediatrics
Sidney Gospe, Jr., M.D., Ph.D.
206-528-5101
Neurology, Pediatrics
Joan M. Goverman, Ph.D.
206-685-7604
Immunology
Thomas J. Grabowski, Jr., M.D.
206-616-0021
Radiology, Neurology
Robert Hevner, M.D., Ph.D.
206-341-5620
Pathology
Philip Horner, Ph.D.
206-341-5715
Neurological Surgery
Suman Jayadev, M.D.
206-221-2930
Neurology
Sandra Juul, M.D., Ph.D.
206-221-6814
Pediatrics
David Kimelman, Ph.D.
206-543-5730
Biochemistry
Natalia Kleinhans, Ph.D.
206-221-6634
Radiology
James Leverenz, M.D.
206-277-1047
Neurology
Kenneth Maravilla, M.D.
206-543-3320
Radiology
Ryan M. McAdams, M.D.
206-616-5681
Pediatrics

Satoshi Minoshima, M.D., Ph.D.

206-543-3320
Radiology
Richard Morrison, Ph.D.
206-543-9654
Neurological Surgery
Pierre D. Mourad, Ph.D.
206-543-9125
Neurological Surgery
Sean Murphy, Ph.D.
206-543-5434
Neurological Surgery
Michael Mustari, Ph.D.
206-616-3476
Ophthalmology
Edward J. Novotny, Jr., M.D.
206-987-3056
Neurology and Pediatrics
Elizabeth Oesterle, Ph.D.
206-616-4108
Otolaryngology/Head and Neck Surgery
Jeffrey Ojemann , Ph.D.
206-987-2544
Neurological Surgery
Jaime Olavarria, Ph.D.
206-543-8675
Psychology
Bensheng Qiu, Ph.D.
206-616-0745
Radiology
Jay Parrish, Ph.D.
206-685-1203
Biology
David J. Perkel, Ph.D.
206-221-2477
Biology, Otolaryngology/Head and Neck Surgery
James Phillips, Ph.D.
206-543-0265
Otolaryngology/Head and Neck Surgery
Nicholas Poolos, M.D., Ph.D.
206-341-5423
Neurology
Thomas A. Reh, Ph.D.
206-543-5069
Biological Structure
Jan-Marino (Nino) Ramirez, Ph.D.
206-884-8188
Neurological Surgery
Bruce Ransom, MD, Ph.D.
206-543-2340
Neurology
Todd Richards, Ph.D.
206-598-6725
Radiology
Robert Rostomily, M.D.
206-543-3570
Neurological Surgery
Edwin Rubel, Ph.D.
206-543-8360
Otolaryngology/Head and Neck Surgery
Jay Rubinstein, M.D., Ph.D.
206-616-6655
Otolaryngology/Head and Neck Surgery
Hannele Ruohola-Baker, Ph.D.
206-543-8468
Biochemistry
Dennis Shaw, M.D.
206-987-2134
Radiology
Nephi Stella, Ph.D.
206-221-5220
Pharmacology, Psychiatry and Behavioral Sciences
Jennifer Stone, Ph.D.
206-616-4108
Otolaryngology/Head and Neck Surgery
Colin Studholme, Ph.D.
206-221-7022
Pediatrics and Bioengineering
Jeffrey Tsai, M.D., Ph.D.
Neurology
John P. Welsh, Ph.D.
206-987-2102
Integrative Brain Research & Pediatrics
Jonathan Weinstein, M.D., Ph.D.
206-221-5362
Neurology
Zhengui Xia, Ph.D.
206-616-9433
Environmental and Occupational Health Sciences, Pharmacology

University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 •chdd@uw.edu