Kristina Adams Waldorf, M.D.

Professor of Obstetrics and Gynecology
Research Affiliate, Center on Human Development and Disability
adamsk@uw.edu
University of Washington
Box 356460
Seattle, WA 98195-6460

Bacterial and viral infections in pregnancy can lead to a spectrum of complications including miscarriage, preterm birth, and injury to the fetus. Pregnancy infections can also disrupt tolerance mechanisms within the placenta and maternal periphery that are critical for maintenance of the pregnancy. Dr. Adams Waldorf’s laboratory is interested in understanding: (1) virulence and host factors that contribute to bacterial and viral trafficking into the amniotic cavity and fetus, (2) how activation of innate immune responses by pathogens within the placenta and amniotic fluid contributes to pregnancy complications and fetal injury, (3) how disruption of maternal-fetal tolerance by pathogens contributes to preterm birth, and (4) the role of novel therapeutics to prevent preterm birth and fetal injury due to pathogens. Within this context, work has been mainly focused on preterm birth and fetal injury related to Group B Streptococcus and, more recently, the Zika virus. Her group is also involved in testing new therapeutics to prevent or stop preterm labor and pregnancy infections.

University of Washington • Center on Human Development and Disability • Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@uw.edu