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Stephen Dager, M.D.

Professor of Radiology
Research Affiliate, Center on Human Development and Disability
University of Washington
Box 354940
Seattle, WA 98195-4940

Dr. Dager

Dr. Dager's research focuses on the development and application of innovative functional imaging techniques to investigate psychiatric and developmental disorders. In investigating the neurobiology of autism and developmental delay, he and his colleagues are studying the time course of brain development using magnetic resonance imaging (MRI) techniques to carefully characterize neuroanatomical changes in relationship to noninvasive measurements of the underlying brain tissue–based chemistry using magnetic resonance spectroscopy (MRS). For this work, Dager’s group is studying young children longitudinally soon after a clinical diagnosis is established. The goal of this research is to better understand both typical brain developmental processes and atypical processes involved in autism and developmental delay.

Dager’s other research projects address characterization of brain pharmacokinetics in both children and adults, including brain uptake, volume of distribution, brain steady-state concentration, and brain elimination half-life, for medications, such as prozac and luvox, that are commonly used to treat autism (as well as other disorders such as depression, anxiety, and obsessive compulsive disorder).  Other research seeks to elucidation brain metabolic mechanisms underlying pathological anxiety states, panic disorder, and bipolar disorder (manic-depressive illness). A current project will characterize the neurocircuitry involved in heroin craving and the effects of treatment intervention.

Stephen Dager's Department of Radiology web site

CHDD Outlook 2013 Issue#5- Brain Imaging and Autism

University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 •