CHDD
CHDD popup menu
 
chdd logo
Center on Human Development and Disability
About CHDD | IDDRC | UCEDD   

CHDD is located on the Lake Washington Ship Canal

Home Page

Collaborative
Research Areas


Research Affiliates

Core Services

Animal
Behavior
Core


Behavioral
Evaluation
Center


Brain
Imaging
Core


Clinical
Translational
Core


Genetics
Core

Clement Furlong, Ph.D.

Professor of Medicine and Genome Sciences
Research Affiliate, Center on Human Development and Disability
clem@uw.edu
206-543-1193
Box 357720
University of Washington
Seattle, WA 98195

Dr. Furlong

Dr. Furlong is interested in the effects of toxin exposure on the nervous system during both pre and post-natal neural development. Of special interest is the evaluation of the effects of a detoxifying enzyme paraoxinase 1 (PON1) on the response to common organophosphate pesticides in the environment. A well-described polymorphism in PON1 significantly impairs the ability of this enzyme to detoxify common pesticides. Furlong and colleagues have recently identified more than 200 additional polymorphisms in this enzyme, potentially explaining the idiosyncratic toxicity of these chemicals in human populations.

In addition, the level of PON1 is very low during the perinatal period, suggesting that exposures during early child development could have much more profound effects than can be observed in adult populations. In particular, he has studied the effects of pre-natal and peri-natal exposure to pesticides normally detoxified by PON1 on wild type and PON1 knock out mice. These studies have revealed that multiple metabolic pathways important for neural development are altered by exposure to pesticides, and that dysfunction is magnified in PON1 deficient animals. Furlong continues to evaluate the effects of pesticide and other environmental neurotoxins on CNS development using a number of rodent models and sophisticated analysis of behavior as well as systems biology approaches.


University of Washington • Center on Human Development and Disability • Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 •chdd@uw.edu