Michael Gale, Jr., Ph.D. Professor of Immunology Research Affiliate, Center on Human Development and Disability mgale@uw.edu 206-543-8514 University of Washington Box 358059 Seattle, WA 98195-8059

Dr. Gale’s lab is focused on understanding the molecular processes of innate immunity, including its role in immune recognition, control of RNA virus infection, and immune programming. The overarching goal in the Gale lab is to define the processes of innate immunity that direct a successful innate immunity and overall immune response for the control of disease, and to understand the processes of virus-induced immune pathology. A primary interest is defining the innate immune action of fetal cells for protection against virus infection, particularly the target cells of Zika virus infection in fetal tissue to prevent neuronal damage and corresponding cognitive consequences. A major goal of this work is to define the molecular basis of pathogen sensing and signaling of innate immunity, to define therapeutic targets to enhance innate immunity for the control of emerging virus infection, and enhancing vaccine efficacy. The Gale lab leverages research findings toward developing small molecule therapeutics for application in antiviral treatment and vaccine enhancement to combat emerging viruses.

For more information on Michael Gale's research activities please see the Department of Immunology website.

University of Washington • Center on Human Development and Disability • Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@uw.edu

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