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Gwenn Garden, M.D., Ph.D.

Professor of Neurology
Research Affiliate, Center on Human Development and Disability
University of Washington
Box 356465
Seattle, WA 98195-6465

Dr. Garden's research involves the molecular pathogenesis of HIV dementia, employing mouse models that closely resemble the pediatric form of HIV dementia. In addition, her work examines the basic cellular biology of apoptosis (cell death) in the central nervous system, especially glial responses to neuronal injury and apoptosis. Garden seeks to understand how the brain responds to a variety of injurious stimuli that promote an inflammatory or excitotoxic reaction in the CNS. Although her research is disease-focused, results of her studies may shed light on important cellular interactions that occur in many other circumstances, including hypoxic and ischemic injury, trauma, seizures, inherited neurodegenerative disease, and mitochondrial disease.

Current research addresses the following questions: (1) Do neurons exposed to the HIV-gp120 coat protein undergo apoptosis when cultured in the presence of microglia (CNS macrophages)? (2) Do proteins involved in apoptosis have an additional role in modulating neuronal architecture? and (3) What is the interaction between apoptotic neurons and microglia?

Gwenn Garden's Department of Neurology web page

CHDD Outlook article (2002)

University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 •