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Sidney M. Gospe, Jr., M.D., Ph.D.

Professor of Neurology and Pediatrics
Research Affiliate, Center on Human Development and Disability
sgospe@uw.edu
206-987-2078
University of Washington
Box 359300, B-5552
Seattle, WA 98195-9300

Dr. Gospe

Dr. Gospe's research concentrates on neurotoxicology, such as the effects of exposure to environmental tobacco smoke on brain development, both pre- and postnatally. Estimates show that one-third to one-half of pregnant women are exposed to secondhand smoke in the workplace or the home. While studies of active smoking by pregnant women show numerous adverse effects, limited clinical studies also show adverse effects of maternal exposure to secondhand smoke, including fetal growth retardation and cognitive impairment. Gospe is undertaking studies to help determine the risks and effects of exposure to sidestream smoke on brain development, and whether the infant brain is more vulnerable to environmental tobacco smoke during certain periods of development.  His earlier work concentrated on the effects of maternal exposure to toluene.

Gospe is also interested in pyridoxine (vitamin B6)-dependent seizures (PDS), a rare familial cause of infantile seizures and associated developmental disability. He collaborates in biochemical and molecular studies of patients with PDS and has established a national registry for patients with this uncommon inherited disorder.


University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 •chdd@uw.edu