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Chronic inflammation associated with HIV/AIDs can damage the central nervous system (CNS), even in individuals treated with anti-viral therapies. As a result, as many as half of the children who contract AIDs may develop some degree of cognitive disability. Dr. Jayadev studies a class of proteins, presenilins, involved in inflammatory cascades that can influence neurodegenerative processes, injuring brain and nerve cells. These proteins are also critical to prenatal development. Therefore her work may contribute to a better understanding of human development, as well as treatments to reduce CNS inflammation in persons with HIV/AIDS.
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