Research
Emphasis Areas

Research Affiliates

Core Services
Behavioral Science Core

Brain Imaging Core

Cellular Morphology Core

Genetics Core

Infant Primate Research Laboratory Core

Instrument Development Laboratory Core

George Martin, M.D.

Professor Emeritus of Pathology
Research Affiliate, Center on Human Development and Disability
gmmartin@u.washington.edu
206-543-5088
University of Washington, Box 357470
Seattle, WA 98195-7470

Dr. Martin's research interests are related to the pathobiology of aging in three broad areas of concentration: the genetic basis for susceptibility and resistance to dementias of the Alzheimer type; the nature of gene action in the pathogenesis of Werner syndrome, a rare autosomal recessive disorder; and DNA damage associated with aging. The research involves the synthesis of cell lines and transgenic mice and investigations of genetic variants in human populations.

Current research has a strong focus on the functions of an adaptor protein within a network of interacting proteins involved in the pathogenesis of dementias of the Alzheimer type. The protein, commonly referred to as FE65, binds to the C-terminal domain of the beta amyloid precursor protein. Recent evidence indicates that it has a major role as a component of a transcriptional complex.

George Martin's web page

University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@u.washington.edu