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Dr. McAdam’s research focuses on three areas. The first is aimed at identifying arterio- and renovascular effects of perinatal asphyxia, hypothermia, recombinant erythropoietin treatments, and umbilical arterial catheter placement in 9 month old nonhuman primates that have undergone perinatal asphyxia and treatment. Second, he studies the effects of neonatal stress on adult aorta and carotid wall intima media and thickness. The objective of this study is to evaluate the long-term vascular effects of neonatal stress. Finally, Dr. McAdams and his group are investigating the mechanisms of infection-associated preterm birth using a chronically cathertized nonhuman primate model to expand our understanding of host-pathogen interactions within the fetal membranes. This work will hopefully provide insights into the early gene pathways activated in acute and chronic lung disease offering opportunities for future therapeutic intervention.
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