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Dr. Minoshima uses imaging techniques for mapping the brain’s activity and structure to study changes that occur early in the progression of Alzheimer’s disease (AD), before symptoms occur. He and his colleagues have discovered very early changes in the posterior cingulate cortex in AD, results that are now considered to be one of the critical imaging findings regarding AD. This research will contribute to better early diagnosis and treatment for AD, which affects adults with Down syndrome. Dr. Minoshima and his colleagues also apply novel in vivo imaging technology to animal models of brain disorders. By increasing understanding of basic brain function, this research is also relevant to conditions such as traumatic brain injury and temporal lobe epilepsy that can contribute to developmental disability in children.
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