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Dr. Murphy studies mechanisms that can protect the brain from damage caused by strokes. Strokes can occur at any age, and are especially devastating in infants. He currently focuses on the potential of two drugs, progesterone and granulocyte stimulating factor (G-CSF), that suppress specific aspects of harmful, post-stroke brain inflammation in animals, resulting in smaller areas of tissue death and preservation of cognitive and motor skills. Murphy also studies the effects of these drugs on the development of new neural cells after stroke. Other research involves targeting of iNOS and nNOS isoforms to discrete cellular compartments, NO in neuroprotection and neurogenesis, and NO and the host response to infection.
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