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Dr. Nance’s research focuses on engineering nanoparticles, both as biophysical probes and imaging biomarkers, to understand disease physiology and pathology in the central nervous system (CNS). Specifically, her lab uses nanotechnology based platforms (polymer, dendrimer, quantum dot) to understand transport limitations at the macro and micro scale in the CNS. Nance developed the first nanoparticles that could both penetrate and move within the brain to improve imaging and treatment of brain disorders including autism, stroke, and cerebral palsy. Her group is particularly interested in using nanotechnology to characterize how common disease hallmarks, such as inflammation, impaired fluid flow, and excitotoxicity, play a role in the ability to diagnose and treat neurodevelopmental disorders including autism, neonatal stroke, traumatic brain injury, and epilepsy.
For more information on her research activities please see Elizabeth Nance's page on the Chemical Engineering website
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