CHDD
CHDD popup menu
 
chdd logo
Center on Human Development and Disability
About CHDD | IDDRC | UCEDD   

CHDD is located on the Lake Washington Ship Canal

Home Page

Collaborative
Research Areas


Research Affiliates

Core Services

Animal
Behavior
Core


Behavioral
Evaluation
Center


Brain
Imaging
Core


Clinical
Translational
Core


Genetics
Core

Wendy Raskind, M.D., Ph.D.

Professor of Medicine and Psychiatry and Behavioral Sciences
Research Affiliate, Center on Human Development and Disability
wendyrun@uw.edu
206-543-3177
University of Washington
Box 357720
Seattle, WA 98195-7720

Dr. Raskind

The focus of research in the Raskind laboratory is to identify and study genes responsible for human inherited disorders, both simple and complex. Raskind and colleagues investigate a variety of neurogenetic disorders, including dystonias, myokymia, myopathies, and ataxias. Probands are ascertained, families are recruited, and linkage analyses are carried out. After the location of the gene responsible for the disease is mapped and the interval containing the gene is narrowed, candidate genes are prioritized and evaluated for mutations. Recently, Raskind and colleagues have discovered that mutations in a serine/threonine kinase gene (protein kinase C gamma) are responsible for an autosomal dominant spinocerebellar ataxia (SCA14). As part of a broad approach to understanding this disease, in-vitro functional assays and creation of mouse models are underway.

In addition to diseases that are inherited in a “simple” Mendelian fashion, Raskind studies behavioral disorders that have complex inheritance patterns. In particular, she is investigating the genetics of dyslexia and related learning disabilities. Phenotypes are targeted on the basis of performance on tests that evaluate reading, writing, and spelling ability, as well as those that assess executive function. Multigenerational families are being studied to characterize, model, and map genetic subtypes of dyslexia.


Wendy Raskind's Genome Sciences web page


University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@uw.edu