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Dr. Rubelís hearing research laboratory utilizes a variety of methods to understand development, plasticity, pathology and repair of the inner ear and auditory pathways of the brain. His lab investigates both the fundamental neurobiology of hearing and translational opportunities directed toward preventing and treating hearing loss. Dr. Rubelís projects include: examining the cellular biology underlying structural and functional development and plasticity of the brain stem auditory pathways, studying how immune signals influence responses to hearing loss in the inner ear and brainstem, and discovering drugs and genes responsible for inner hair cell death due to ototoxic drugs or aging. One long-term goal is to develop drugs to prevent hearing loss. One drug developed by this collaborative project is in the late stages of development for clinical trials.
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