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Center on Human Development and Disability
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Stephen E. P. Smith, Ph.D.

Assistant Professor of Pediatrics
Research Affiliate, Center on Human Development and Disability
seps@uw.edu
206-884-7324
University of Washington
Box 356320
Seattle, WA 98195-6320

Stephen E. P. Smith

Dr. Smith’s research focuses on how the diverse genetic and environmental insults converge on common cellular or molecular processes to cause the core symptoms of autism spectrum disorder. Smith’s lab uses a combination of approaches, including a powerful new proteomic technique (Quantitative Multiplex Immunoprecipitation), to develop a mechanistic understanding of how networks of interacting proteins, which have each been independently genetically linked to autism, transmit synapse-modifying signals at the glutamate synapse and modulate social behavior in mice and humans. Smith’s ultimate goal is to define common mechanisms of action shared among different autism risk factors in order to identify biologically meaningful subgroups of patients with autism; to identify novel drug targets that correct synaptic deficits in autism; and to explore fundamental mechanisms of glutamate synapse homeostasis and function.

Stephen E. P. Smith's SEPS lab webpage


University of Washington • Center on Human Development and Disability • Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@uw.edu