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Dr. Tapscott's research focuses on genetic regulation of the development of muscle and the nervous system, as well as on molecular mechanisms of genetic muscle disease such as myotonic dystrophy and Duchenne muscular dystrophy. He and colleagues are interested in determining whether stem cells derived from bone marrow or skeletal muscle can be developed as a possible source of skeletal muscle for the treatment of Duchenne muscular dystrophy.
Current research interests include chromatin structure and the regulation of gene transcription in determining how master regulatory factors drive programs of cell differentiation; the molecular characteristics of neurogenic bHLH proteins in the activation of neural promoters and induction of neurogenesis; chromatin structure and gene expression in myotonic dystrophy and fragile X syndrome; and the possible use of muscle stem cells in the treatment of Duchenne muscular dystrophy.
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