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Dr. Unadkat's research interests are in elucidating mechanisms of disposition of drugs used in the treatment of AIDS and associated opportunistic infections. In particular, his laboratory conducts research on transport of anti-AIDS drugs across the placenta, intestine, and blood-brain/cerebrospinal fluid barrier. These studies have focused on mechanisms of transport by two major families of transporters: the nucleoside transporters and the ABC transporters.
Unadkat's laboratory is also involved in determining the mechanisms of metabolism of anti-AIDS drugs, including drug interaction. Translation of research findings from in vitro to in vivo is a key element in these research activities. He currently heads a specialized research center that focuses on Women’s Health. The goal is to elucidate the mechanisms by which transporters and enzymes alter maternal and fetal drug exposure during pregnancy.
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