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Research |
Dr. Unadkat's research interests are in elucidating mechanisms of disposition of drugs used in the treatment of AIDS and associated opportunistic infections. In particular, his laboratory conducts research on transport of anti-AIDS drugs across the placenta, intestine, and blood-brain/cerebrospinal fluid barrier. These studies have focused on mechanisms of transport by two major families of transporters: the nucleoside transporters and the ABC transporters. Unadkat's laboratory is also involved in determining the mechanisms of metabolism of anti-AIDS drugs, including drug interaction. Translation of research findings from in vitro to in vivo is a key element in these research activities. He currently heads a specialized research center that focuses on Women’s Health. The goal is to elucidate the mechanisms by which transporters and enzymes alter maternal and fetal drug exposure during pregnancy. University of Washington • Center on Human Development and Disability Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701 • chdd@u.washington.edu Copyright © 1996—2008 Center on Human Development and Disability. Updated: July 20, 2006 | |||