Libin Xu, Ph.D.
Assistant Professor of Medicinal Chemistry
Research Affiliate, Center on Human Development and Disability
University of Washington
Seattle, WA 98195-7910
Dr. Xu’s research is designed to understand the role of oxidized sterols (oxysterols) in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a cholesterol biosynthesis disorder that affects central nervous system development. SLOS manifests in a broad spectrum of phenotypes including multiple congenital malformations, neurological defects, intellectual disability, and behavior problems. Over 70% of SLOS children display autism spectrum disorder. Xu’s goals are to examine the effect of these oxysterols on lipidome by mass spectrometry and transcriptome by qPCR and sequencing. His research contributes to a broader understanding of intellectual and developmental disabilities, particularly disorders of metabolism that affect brain function and development. Also of interest are the mechanisms of action of common ammonium environmental toxins in neuronal cells using metabolomic and transcriptomic approaches.
Dr. Xu’s laboratory website
University of Washington • Center on Human Development
and Disability • Box 357920 • Seattle WA 98195-7920 USA • 206-543-7701
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January 11, 2019