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Niels H. Andersen

Representative Publications

Folding Landscape Exploration by Capping b Structures and Circular Permutation, B. Kier, A. Byrne, J. Anderson, M. Scian, I. Shu & N. H. Andersen, 32nd EPS Symp. Vol., in press.

Probing Alpha-Synuclein Molecular Binding Sites and their Effects on Aggregation by NMR Spectroscopy, A.Byrne, M. Bisaglia, L. & N. H. Andersen, 32nd EPS Symp. Vol., in press.

Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction, M. Scian, J. C. Lin, I. Le Trong, G. I. Makhatadze, R. E. Stenkamp & N. H. Andersen, Proc. Natl. Acad. Sci. USA, 109, in press (2012).

Designed Hairpin Peptides Interfere with Amyloidogenesis Pathways: Fibril Formation and Cytotoxicity Inhibition, Interception of the Preamyloid State, K. N. L. Huggins, M. Bisaglia, L. Bubacco, M. Tatarek-Nossol, A. Kapurniotu & N. H. Andersen, Biochemistry, 50, 8202-8212 (2011).


Concerning the Optimal Salt Bridge for Trp-cage Stabilization, D. V. Williams, A. Byrne, J. M. Stewart & N. H. Andersen, Biochemistry, 50, 1143-1152 (2011).

β-Sheet 13C Structuring Shifts Appear only at the H-bonded Sites of Hairpins, I. Shu, J. M. Stewart, M. Scian, B. L. Kier & N. H. Andersen, J. Am. Chem. Soc., 133, 1196-1199 (2011). 

Designed Hairpins Modulate the Amyloidogenesis of a Synuclein: Oligomerization Inhibition and Diversion to Non-amyloid Aggregates, N. H. Andersen, K. N. L. Huggins, M. Bisaglia & L. Bubacco, 31st EPS Symp. Vol., 22-23 (2010).

Stabilizing Capping Motif for β Hairpins and Sheets, B. L. Kier, I. Shu, L. A. Eidenschink & N. H. Andersen, Proc. Natl. Acad. Sci. USA, 107, 10466-10471 (2010).

Terminal side-chain packing of a designed β-hairpin influences its conformation and stability, L. Eidenschink, E. Crabbe & N. H. Andersen, Biopolymers, 91, 557-564 (2009).

Solution-state Structures of Human Pancreatic Amylin and Pramlintide, J. R. Cort, Z. Liu, G. M. Lee, K. N. L. Huggins, S. Janes, K. Prickett & N. H. Andersen, Protein Engineering Design and Selection, 22, 497-513 (2009).

Development of Calcitonin Salmon Nasal Spray: Similarity of peptide formulated in chlorobutanol compared to benzalkonium chloride as preservative, H. R. Costantino, H. Culley, L. Chen, D. Morris, M. Houston, S. Roth, M. J. Phoenix, C. Foerder, J. S. Philo, T. Arakawa, L. A. Eidenschink, N. H. Andersen, G. Brandt & S. C. Quay, J. Pharmaceutical Sciences, 98, 3691-3706 (2009). 

Very Short Peptides with Stable Folds: Building on the Inter-relationship of Trp/Trp, Trp/cation, and Trp/backbone-amide Interaction Geometries, L. A. Eidenschink, B. L. Kier, K. Huggins & N. H. Andersen, Proteins: Structure, Function & Bioinformatics, 75, 308-322 (2009).


Hyperstable Miniproteins: Additive Effects of D- and L-Ala Mutations, D. V. Williams, B. Barua, N. H. Andersen, Organic & Biomolecular Chemistry, 6,4287-4289 (2008).

Probing the Lower Size Limit for Protein-like Fold Stability: Ten-residue Microproteins with Specific, Rigid Structures in Water, B. L. Kier & N. H. Andersen, J Am Chem. Soc., 130, 14675-14683 (2008).

Lysine and arginine residues do not increase the helicity of alanine-rich peptide helices, J. M. Stewart, J. C. Lin & N. H. Andersen, Chem. Commun., 4765-4767 (2008).

Structural insights for designed alanine-rich helices: Comparing NMR helicity measures and conformational ensembles from molecular dynamics, K. Song, J. Stewart, R. M. Fesinmeyer, N. H. Andersen & C. Simmerling,  Biopolymers, 89, 747-760 (2008).

The Trp-cage: Optimizing the Stability of a Globular Miniprotein, B. Barua, J. C. Lin, D. V. Williams, J. W. Neidigh, P. Kummler & N. H. Andersen, Protein Engineering Design and Selection, 21, 171-185 (2008).

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein, K. H. Mok, L. T. Kuhn, M. Goez, I. J. Day, J. C. Lin, N. H. Andersen & P. J. Hore, Nature, 447, 106-109 (2007).

Measuring Cooperativity in the Formation of a Three-stranded b sheet (Double Hairpin), F. M. Hudson & N. H. Andersen, Biopolymers, 83, 424-433 (2006).

Minimization and Optimization of Designed b Hairpin Folds, N. H. Andersen, K. A. Olsen, R. M. Fesinmeyer, X. Tan, F. M. Hudson, L. A. Eidenschink & S. R. Farazi, J. Am. Chem. Soc., 128, 6101-6110 (2006).

Chemical Shifts Provide Fold Populations and Register of b-Hairpins and b-Sheets, R. M. Fesinmeyer, F. M. Hudson, K. A. Olsen, G. W. N. White, A. Euser & N. H. Andersen, J. Biomolecular NMR, 33, 213-231 (2005).

Hairpin folding rates reflect mutations within and remote from the turn region, K. A. Olsen, R. M. Fesinmeyer, J. Stewart  & N. H. Andersen, Proc. Natl. Acad. Sci. USA, 102, 15483-15487 (2005).

Studies of Helix Fraying and Solvation Using 13C’ Isotopomers, R. M. Fesinmeyer, Eric S. Peterson, R. Brian Dyer & N. H. Andersen, Protein Sci., 14, 2324-2332 (2005).

Hairpin Folding Dynamics: The Cold-denatured State is Predisposed for Rapid Refolding, R. B. Dyer, S. J. Maness, S. Franzen, R. M. Fesinmeyer, K. A. Olsen & N. H. Andersen, Biochemistry, 44, 10406-10415 (2005).

The Helical Alanine Controversy: An (Ala)6 Insertion Dramatically Increases Helicity, J. C. Lin, B. Barua & N. H. Andersen, J. Am. Chem. Soc., 126, 13679-13684 (2004). 

Exenatide: NMR/CD Evaluation of the Medium Dependence of Conformation and Aggregation State, F. M. Hudson & Niels H. Andersen, Biopolymers (Peptide Science), 76, 298-308 (2004).

The Mechanism of b Hairpin Formation, R. B. Dyer, S. J. Maness, E. S. Peterson, S. Franzen, R. M. Fesinmeyer & N. H. Andersen, Biochemistry, 43, 11560-11566 (2004).  PMID: 15350142.

Enhanced Hairpin Stability through Loop Design, the Case of the Protein G B1 Domain Hairpin, R. M. Fesinmeyer, F. M. Hudson & N. H. Andersen, J. Am. Chem. Soc., 126, 7238-7243 (2004).

19F NMR Studies of Tryptophan/Serum Albumin Binding, Bolong Cao, Stephanie Endsley & Niels H. Andersen, Bioorganic & Medicinal Chemistry, 11, 69-75 (2003).

Determinants of Miniprotein Stability: Can anything replace a buried H-bonded Trp sidechain, Bipasha Barua & Niels H. Andersen, Letters in Peptide Science, 8, 221-226 (2002).

Peptide Conformational Changes Induced by Tryptophan-Phosphocholine Interactions in a Micelle, J. W. Neidigh & N. H. Andersen, Biopolymers, 65, 354-361 (2002).

Potent, Novel in Vitro Inhibitors of the Pseudomonas aeruginosa Deacetylase LpxC , T. Kline, N. H. Andersen, E. A. Harwood, J. Bowman, A. Malanda, S. Endsley, A. L. Erwin, M. Doyle, S. Fong, A. L. Harris, B. Mendelsohn, K. Mdluli, C. R. H. Raetz, C. K. Stover, P. R. Witte, A. Yabannavar & S. Zhu, J. Med. Chem., 45, 3112-3129 (2002).

Activation of Erythropoietin Receptor through a Novel Extracellular Binding Site, T. Naranda, R. I. Kaufman, J. Li, K. Wong, A. Boge, D. Hallen, K. Y. C. Fung, M. W. Duncan, N. Andersen, A. Goldstein & L. Olsson, Endocrinology, 143, 2293-2302 (2002).

Designing a 20-Residue Protein, J. W. Neidigh, R. M. Fesinmeyer & N. H. Andersen, Nature Struct. Biol.. 9, 425-430 (2002).

Dynamics of the Primary Processes of Protein Folding: Helix Nucleation, J. H. Werner, R. B. Dyer, R. M. Fesinmeyer & N.H. Andersen, J. Phys. Chem. B, 106, 487-494 (2002).

Extracting Information from the Temperature Gradients of Polypeptide NH Chemical Shifts:  I. The Importance of Conformational Averaging, N. H. Andersen, J. Neidigh, S. M. Harris, G. M. Lee, Z. Liu, & H. Tong, J. Am. Chem. Soc., 119, 8547-8561 (1997).


Empirical Parameterization of a Model for Predicting Peptide Helix/Coil Equilibrium Populations, N. H. Andersen & H. Tong, Protein. Sci., 6, 1920-1936 (1997).


Back to Research Interests

Back to Research Interests

Awards & Activities

NIH Career Development Award

Dreyfus Teacher-Scholar Award

Alfred P. Sloan Research Fellow

Scientific Advisory Board, Biopolymers, 2002 forward

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