Neils H. Andersen

Representative Publications

Hyperstable Miniproteins: Additive Effects of D- and L-Ala Mutations, D. V. Williams, B. Barua, N. H. Andersen, Organic & Biomolecular Chemistry, 6,4287-4289 (2008).


Probing the Lower Size Limit for Protein-like Fold Stability: Ten-residue Microproteins with Specific, Rigid Structures in Water, B. L. Kier & N. H. Andersen, J Am Chem. Soc., 130, 14675-14683 (2008).


Lysine and arginine residues do not increase the helicity of alanine-rich peptide helices, J. M. Stewart, J. C. Lin & N. H. Andersen, Chem. Commun., 4765-4767 (2008).


Structural insights for designed alanine-rich helices: Comparing NMR helicity measures and conformational ensembles from molecular dynamics, K. Song, J. Stewart, R. M. Fesinmeyer, N. H. Andersen & C. Simmerling,  Biopolymers, 89, 747-760 (2008).

 
The Trp-cage: Optimizing the Stability of a Globular Miniprotein, B. Barua, J. C. Lin, D. V. Williams, J. W. Neidigh, P. Kummler & N. H. Andersen, Protein Engineering Design and Selection, 21, 171-185 (2008).

 
A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein, K. H. Mok, L. T. Kuhn, M. Goez, I. J. Day, J. C. Lin, N. H. Andersen & P. J. Hore, Nature, 447, 106-109 (2007).


Measuring Cooperativity in the Formation of a Three-stranded b sheet (Double Hairpin), F. M. Hudson & N. H. Andersen, Biopolymers, 83, 424-433 (2006).


Minimization and Optimization of Designed b Hairpin Folds, N. H. Andersen, K. A. Olsen, R. M. Fesinmeyer, X. Tan, F. M. Hudson, L. A. Eidenschink & S. R. Farazi, J. Am. Chem. Soc., 128, 6101-6110 (2006).


Chemical Shifts Provide Fold Populations and Register of b-Hairpins and b-Sheets, R. M. Fesinmeyer, F. M. Hudson, K. A. Olsen, G. W. N. White, A. Euser & N. H. Andersen, J. Biomolecular NMR, 33, 213-231 (2005).

 
Hairpin folding rates reflect mutations within and remote from the turn region, K. A. Olsen, R. M. Fesinmeyer, J. Stewart  & N. H. Andersen, Proc. Natl. Acad. Sci. USA, 102, 15483-15487 (2005).


Studies of Helix Fraying and Solvation Using 13C’ Isotopomers, R. M. Fesinmeyer, Eric S. Peterson, R. Brian Dyer & N. H. Andersen, Protein Sci., 14, 2324-2332 (2005).


Hairpin Folding Dynamics: The Cold-denatured State is Predisposed for Rapid Refolding, R. B. Dyer, S. J. Maness, S. Franzen, R. M. Fesinmeyer, K. A. Olsen & N. H. Andersen, Biochemistry, 44, 10406-10415 (2005).


The Helical Alanine Controversy: An (Ala)6 Insertion Dramatically Increases Helicity, J. C. Lin, B. Barua & N. H. Andersen, J. Am. Chem. Soc., 126, 13679-13684 (2004). 


Exenatide: NMR/CD Evaluation of the Medium Dependence of Conformation and Aggregation State, F. M. Hudson & Niels H. Andersen, Biopolymers (Peptide Science), 76, 298-308 (2004).


The Mechanism of b Hairpin Formation, R. B. Dyer, S. J. Maness, E. S. Peterson, S. Franzen, R. M. Fesinmeyer & N. H. Andersen, Biochemistry, 43, 11560-11566 (2004).  PMID: 15350142.


Enhanced Hairpin Stability through Loop Design, the Case of the Protein G B1 Domain Hairpin, R. M. Fesinmeyer, F. M. Hudson & N. H. Andersen, J. Am. Chem. Soc., 126, 7238-7243 (2004).


19F NMR Studies of Tryptophan/Serum Albumin Binding, Bolong Cao, Stephanie Endsley & Niels H. Andersen, Bioorganic & Medicinal Chemistry, 11, 69-75 (2003).

 
Determinants of Miniprotein Stability: Can anything replace a buried H-bonded Trp sidechain, Bipasha Barua & Niels H. Andersen, Letters in Peptide Science, 8, 221-226 (2002).


Peptide Conformational Changes Induced by Tryptophan-Phosphocholine Interactions in a Micelle, J. W. Neidigh & N. H. Andersen, Biopolymers, 65, 354-361 (2002).


Potent, Novel in Vitro Inhibitors of the Pseudomonas aeruginosa Deacetylase LpxC , T. Kline, N. H. Andersen, E. A. Harwood, J. Bowman, A. Malanda, S. Endsley, A. L. Erwin, M. Doyle, S. Fong, A. L. Harris, B. Mendelsohn, K. Mdluli, C. R. H. Raetz, C. K. Stover, P. R. Witte, A. Yabannavar & S. Zhu, J. Med. Chem., 45, 3112-3129 (2002).

  
Activation of Erythropoietin Receptor through a Novel Extracellular Binding Site, T. Naranda, R. I. Kaufman, J. Li, K. Wong, A. Boge, D. Hallen, K. Y. C. Fung, M. W. Duncan, N. Andersen, A. Goldstein & L. Olsson, Endocrinology, 143, 2293-2302 (2002).


Designing a 20-Residue Protein, J. W. Neidigh, R. M. Fesinmeyer & N. H. Andersen, Nature Struct. Biol.. 9, 425-430 (2002).


Dynamics of the Primary Processes of Protein Folding: Helix Nucleation, J. H. Werner, R. B. Dyer, R. M. Fesinmeyer & N.H. Andersen, J. Phys. Chem. B, 106, 487-494 (2002).


Extracting Information from the Temperature Gradients of Polypeptide NH Chemical Shifts:  I. The Importance of Conformational Averaging, N. H. Andersen, J. Neidigh, S. M. Harris, G. M. Lee, Z. Liu, & H. Tong, J. Am. Chem. Soc., 119, 8547-8561 (1997).

 

Empirical Parameterization of a Model for Predicting Peptide Helix/Coil Equilibrium Populations, N. H. Andersen & H. Tong, Protein. Sci., 6, 1920-1936 (1997).

 

Back to Research Interests

Back to Research Interests

Awards & Activities

NIH Career Development Award

Dreyfus Teacher-Scholar Award

Alfred P. Sloan Research Fellow

Scientific Advisory Board, Biopolymers, 2002 forward

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