Assistant Professor of Chemistry
Ph.D. University of Texas at Austin, 2007
(Organic, Organometallic, and Polymer Chemistry)
Mechanochemical Transduction in Polymeric Systems:
Investigations in the Boydston group focus on developing polymers and materials that undergo controlled, autonomic responses to environmental stimuli, particularly mechanical impetus. Our group seeks to understand how polymer architecture and composition influence mechanochemical reactivity, and how mechanochemical transduction can be used to design functional materials. Main focus areas include the development of new mechano-responsive functional groups, environmental influences on mechanochemical efficiency, and amplification of chemical reactions driven by the application of force. At the fundamental level, we are interested in how different force-guided structural changes (e.g., bending versus stretching versus torsion) translate into chemo-mechanical coupling efficiency and selectivity, how chemical catalysis can be combined with mechanical impetus, the use of mechanical energy to initiate spontaneous reaction cascades, and how branch points in macromolecular structures distribute forces resulting from stress and strain. We are motivated by potential for mechanochemical reactivity to impact important areas such as drug delivery, sensory materials, and self-reinforcing materials.
Organocatalyzed Electro-organic Synthesis:
Achieving improved and broadened synthetic capabilities is key to the development of advanced materials and efficient syntheses of target molecules. Redox reactions are some of the most important and fundamental processes to the synthetic chemist. Our group is targeting new reactions at the interface of electro-organic synthesis and organocatalysis to effect oxidations and reductions of organic substrates in a metal-free manner. By conducting experiments under a controlled cell potential, we are able to intercept reactive intermediates generated during organocatalyzed transformations and electrochemically change their oxidation states. Notably, electrochemical techniques can provide unique selectivity and reaction efficiency not achieved by stoichiometric oxidants and reductants.
Peterson, G. I.; Boydston, A. J. "Modeling the Mechanochemical Degradation of Star Polymers." Macromol. Theory Simul. 2014, accepted.
Church, D. C.; Peterson, G. I.; Boydston, A. J. “Comparison of Mechanochemical Chain Scission Rates for Linear versus Three-Arm Star Polymers in Strong Acoustic Fields.” ACS Macro Lett. 2014, 3, 648-651.
Diesendruck, C. E.; Peterson, G. I.; Kulik, H. J.; Kaitz, J. A.; Mar, B. D.; May, P. A.; White, S. R.; Martínez, T. J.; Boydston, A. J.; Moore, J. S. “Mechanically-Triggered Heterolytic Unzipping of a Low Ceiling Temperature Polymer.” Nat. Chem. 2014, 6, 623-628.
Ogawa, K. A.; Boydston, A. J. "Electrochemical Characterization of Azolium Salts." Chem. Lett. 2014, 43, 907-909.
Ogawa, K. A.; Boydston, A. J. "Anodic Oxidation of Aldehydes to Thioesters." Org. Lett. 2014, 16, 1928-1931.
Larsen, M. B.; Boydston, A. J. "Successive Mechanochemical Activation and Small Molecule Release in an Elastomeric Material." J. Am. Chem. Soc. 2014, 136, 1276-1279.