Champak Chatterjee

Representative Publications

 

Whedon, S. D.; Markandeya, N.; Rana, A. S.; Weller, C. E.; Senger, N. A.; Turecek, F.; Strieter, E. R.; Chatterjee, C. Selenocysteine as a latent bioorthogonal electrophilic probe for deubiquitylating enzymes. J. Am. Chem. Soc. 2016, 138, 13774–13777.

 

Dhall, A.; Wei, S.; Fierz, B.; Woodcock, C. L.; Lee, T. H.; Chatterjee, C. Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions. J. Biol. Chem. 2014, 289, 33827–33837.

 

Smirnov, D.; Dhall, A.; Sivanesam, K.; Sharar, R. J.; Chatterjee, C. Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2013, 135, 2887–2890.

 

Meier, F.; Abeywardana, T.; Dhall, A.; Marotta, N. P.; Varkey, J.; Langen, R.; Chatterjee, C.; Pratt, M. R. Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation. J. Am. Chem. Soc. 2012, 134, 5468–5471.

 

Fierz, B.; Chatterjee, C.; McGinty, R.K.; Bar-Dagan, M.; Raleigh, D.P.; Muir, T.W. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat. Chem. Biol. 2011, 7, 113–119.

 

Chatterjee, C.; McGinty, R.K.; Fierz, B.; Muir, T. W. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nat. Chem. Biol. 2010, 6, 267–269.

 

McGinty, R.K.; Kohn, M.; Chatterjee, C.; Chiang, K.P; Pratt, M.R.; Muir, T.W. Structure activity analysis of semisynthetic nucleosomes: Mechanistic insights of the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem. Biol. 2009, 4, 958–968.

 

Levengood, M.R.; Kerwood, C.C.; Chatterjee, C.; van der Donk, W.A. Investigations of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. ChemBioChem 2009, 10, 911–919.

 

Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A. The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry 2008, 47, 7342–7351.

 

Furgerson Ihnken, L.A.; Chatterjee, C.; van der Donk, W.A. In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry 2008, 47, 7352–7363.

 

Miller, L.M.; Menthena, A.: Chatterjee, C.; Verdier-Pinard, P.; Novikoff, P. Horwitz, S.B.; Angeletti, R.H. Increased levels of a unique post-translationally modified bIVb-tubulin isotype in liver cancer. Biochemistry 2008, 47, 7572–7582.

 

McGinty, R.K.; Kim, J.; Chatterjee, C.; Roeder, R.G.; Muir, T.W. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature 2008, 453, 812–816.

 

Chatterjee, C.; McGinty, R.K.; Pellois, J.-P.; Muir, T.W. Auxiliary-mediated site-specific peptide ubiquitylation. Angew. Chem., Int. Ed. 2007, 46, 2814–2818.

 

Chatterjee, C.*; Patton, G.C.*; Cooper, L.; Paul, M.; van der Donk, W.A. Engineering dehydro amino acids and thioethers into peptides using Lacticin 481 synthetase. Chemistry & Biology 2006, 13, 1109–1117.

 

Miller, L.M.; Chatterjee, C.; van der Donk, W.A.; Kelleher, N.L. The dehydratase activity of Lacticin 481 synthetase is highly processive. J. Am. Chem. Soc. 2006, 128, 1420-1421.

 

Chatterjee, C.; Miller, L.M.; Leung, Y.L.; Xie, L.; Yi, M.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J. Am. Chem. Soc. 2005, 127, 15332-15333.

 

Xie, L.; Miller, L.M.; Chatterjee, C.; Averin, O.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science 2004, 303, 679–681.

 

Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A. Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem. Biophys. Res. Commun. 2002, 295, 952–957.

 

Review Articles

Weller, C.E.; Pilkerton, M.E.; Chatterjee, C. Chemical strategies to understand the language of ubiquitin signaling. Biopolymers 2014, 101, 144-55.

 

Dhall, A.; Chatterjee, C. Chemical approaches to understand the language of histone modifications. ACS Chem. Biol. 2011, 6, 987-999.

 

Chatterjee, C.; Muir, T. W. Chemical approaches for studying histone modifications. J. Biol. Chem. 2010, 285, 11045–11050.

 

McGinty, R.K.; Chatterjee, C.; Muir, T.W. Semisynthesis of ubiquitylated proteins. Methods Enzymol. 2009, 462, 225–243.

 

Chatterjee, C.; Paul, M.; Xie, L.; van der Donk, W.A. Biosynthesis and mode of action of lantibiotics. Chem. Rev. 2005, 105, 633–684.

 

Research Highlights

All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting, ChemBioChem 2015, 16, 2531-6.

Talk among histones, Nature Methods 2008, 5, 662-663.
Chemical answers to epigenetic crosstalk, Nature Chemical Biology 2008, 4, 335–337.
A synthetic kiss of death, ChemBioChem 2007, 8, 1221–1223.
Toward novel lantibiotics, Chemical and Engineering News 2004, 82(5),10.

 

Selected Presentations

2017   The 7th Chemical Protein Synthesis Meeting, Haifa, Israel

2017   Chemistry-Biology Interface Mini-Symposia Series, University of Pennsylvania Philadelphia (student invited)

2016   Gordon Research Conference on Chemistry and Biology Peptides, Ventura, California

2015    Frontiers in Chromatin Biology and Chemical Epigenetic/Epigenomics, Pacifichem, Hawaii

2009    ACS National Meeting, Washington, D.C. Organic chemistry division, speaker
2009    Gordon Research Conference on Enzymes, Coenzymes & Metabolic Pathways, poster
2008    Fairleigh Dickinson University, Madison, NJ, speaker
2007    IIT Bombay, Department of Chemistry, speaker
2004    ACS National Meeting, Philadelphia, PA. Organic chemistry division, speaker

 

Back to Research Interests

 

Site Map | Contact Us