Champak Chatterjee

Representative Publications


Miller, L.M.; Menthena, A.: Chatterjee, C.; Verdier-Pinard, P.; Novikoff, P. Horwitz, S.B.; Angeletti, R.H. "Increased levels of a unique post-translationally modified bIVb-tubulin isotype in liver cancer." Biochemistry 2008, 47, 7572-7582.
McGinty, R.K.; Kim, J.; Chatterjee, C.; Roeder, R.G.; Muir, T.W. "Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation." Nature 2008, 453, 812-816.
Chatterjee, C.; McGinty, R.K.; Pellois, J.-P.; Muir, T.W. "Auxiliary-mediated site-specific peptide ubiquitylation." Angew. Chem. Int. Ed. Engl. 2007, 46, 2814-2818.


Chatterjee, C.*; Patton, G.C.*; Cooper, L.; Paul, M.; van der Donk, W.A. Engineering dehydro amino acids and thioethers into peptides using Lacticin 481 synthetase Chemistry and Biology 2006, 13, 1109-1117.


Miller, L.M.; Chatterjee, C.; van der Donk, W.A.; Kelleher, N.L. The dehydratase activity of Lacticin 481 synthetase is highly processive J. Am. Chem. Soc. 2006, 128, 1420-121.


Chatterjee, C.; Miller, L.M.; Leung, Y.L.; Xie, L.; Yi, M.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production J. Am. Chem. Soc. 2005, 127, 15332-15333.


Xie, L.; Miller, L.M.; Chatterjee, C.; Averin, O.; Kelleher, N.L.; van der Donk, W.A. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity Science 2004, 303, 679-681.


Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A. Heterologous expression and purification of SpaB involved in subtilin biosynthesis Biochem. Biophys. Res. Commun. 2002, 295, 952-957.


Review Articles:

Chatterjee, C.; Paul, M.; Xie, L.; van der Donk, W.A. Biosynthesis and mode of action of lantibiotics Chem. Rev. 2005, 105, 633-683.

McGinty, R.K.; Chatterjee, C.; Muir, T.W. Semisynthesis of ubiquitylated proteins Methods Enzymol. 2009, 462, 225-243.

Chatterjee, C.; Muir, T. W. Chemical approaches for studying histone modifications J. Biol. Chem. 2010, doi:10.1074/jbc.R109.080291

Fierz, B.; Chatterjee, C.; McGinty, R.K.; Muir, T.W. Ubiquitylated H2B acts as a molecular wedge disrupting chromatin fibres (under revision at Nature)


Research Highlights:

Talk among histones, Nature Methods 2008, 5, 662-663.
Chemical answers to epigenetic crosstalk Nature Chemical Biology 2008, 4, 335-337.
A synthetic kiss of death ChemBioChem 2007, 8, 1221-1223.
Toward novel lantibiotics Chemical and Engineering News 2004, 82(5),10.



Selected Presentations:

2009    ACS National Meeting, Washington, D.C. Organic chemistry division, speaker
2009    Gordon Research Conference on Enzymes, Coenzymes & Metabolic Pathways, poster
2008    Fairleigh Dickinson University, Madison, NJ, speaker
2007    IIT Bombay, Department of Chemistry, speaker
2004    ACS National Meeting, Philadelphia, PA. Organic chemistry division, speaker


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