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Paul B. Hopkins

Representative Publications

Chemical Cross-Linking of Drugs to DNA., R. A. Luce and P. B. Hopkins, Methods Enzymol., 340 396 (2001).


Chemical Synthesis of Cross-Link Lesions Found in Nitrous Acid Treated DNA: A General Method for the Preparation of N2-Substituted 2'-Deoxyguanosines., E. A. Harwood, P. B. Hopkins, S. Th. Sigurdsson, J. Org. Chem., 65 2959 (2000).


Sequence-Dependent Dynamics in Duplex DNA., T.M. Okonogi, S. C. Alley, A. W. Reese, P. B. Hopkins, B. H. Robinson, Biophys. J., 78 2560 (2000).


Flexibility of Duplex DNA on the Submicrosecond Timescale., T.M. Okonogi, A. W. Reese, S. C. Alley, P. B. Hopkins, B. H. Robinson, Biophys. J., 77 3256 (1999).


Monoalkylation of DNA by Reductively Activated FR66979., M. M. Paz, S. Th. Sigurdsson, and P. B. Hopkins, Bioorg. Med. Chem., 8 173 (2000).


Direct Demonstration in Synthetic Oligonucleotides that BCNU Cross-Links N1 of Deoxyguanosine to N3 of Deoxycytidine on Opposite Strands of Duplex DNA., P. L. Fischhaber, A. S. Gall, J. A. Duncan, and P. B. Hopkins, Cancer Research, 59 4363 (1999).


Quantification of Formaldehyde-Mediated Covalent Adducts of Adriamycin with DNA., R. A. Luce, S. Th. Sigurdsson, and P. B. Hopkins, Biochemistry, 38 8682 (1999).


Chemical Synthesis and Preliminary Structural Characterization of a Nitrous Acid Interstrand Cross-Linked Duplex DNA., E. A. Harwood, S. Th. Sigurdsson, N. B. F. Edfeldt, B. R. Reid, and P. B. Hopkins, J. Am. Chem. Soc., 121 5081 (1999).


Effect of Nucleosome Structure on DNA Interstrand Cross-Linking Reactions., J. T. Millard, R. J. Spencer, and P. B. Hopkins, Biochemistry, 37 5211 (1998).


Synthesis of Duplex DNA Containing a Rigidly Spin-Labeled Analogue of 2'-Deoxycytidine., P. L. Fischhaber, A. W. Reese, T. Nguyen, J. J. Kirchner, E. J. Hustedt, B. H. Robinson, and P. B. Hopkins, Nucleosides and Nucleotides, 16 365 (1997).


DNA-DNA Interstrand Cross-Linking by FR66979: Intermediates in the Activation Cascade., M. M. Paz and P. B. Hopkins, J. Am. Chem. Soc., 119 5999 (1997).


DNA-DNA Interstrand Cross-Linking by FR66979 and FR900482: Requirement of Metal Ions During Reductive Activation., M. M. Paz and P. B. Hopkins, Tetrahedron Lett. 38 343 (1997).


Bending of DNA by the Mitomycin C-Induced, GpG Intrastrand Cross-Link., S. M. Rink, R. Lipman, S. C. Alley, P. B. Hopkins, and M. Tomasz, Chem. Res. Toxicol., 9 382 (1996).


Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link., H. Huang, L. Zhu, B. R. Reid, G. P. Drobny and P. B. Hopkins, Science, 270 1842 (1995).


An NMR Study of [d(CGCGAATTCGCG)]2 Containing an Interstrand Cross-Link Derived from a Distamycin-Pyrrole Conjugate., P. A. Fagan, H. P. Spielmann, S. Th. Sigurdsson, S. M. Rink, P. B. Hopkins, and D. E. Wemmer, Nucleic Acids Res., 24 1566 (1996).


Direct Evidence for DNA-DNA Intrastrand Cross-Linking at 5'-d(GG) by Mechlorethamine., S. M. Rink and P. B. Hopkins, Bioorg. Med. Chem. Lett., 5 2845 (1995).


A Probe for Sequence-Dependent Nucleic Acid Dynamics., T. R. Miller, S. C. Alley, A. Reese, M. S. Solomon, W. McCallister, C. Mailer, B. H. Robinson, and P. B. Hopkins, J. Am. Chem. Soc., 117 9377 (1995).


DNA-DNA Interstrand Cross-Linking by cis-Diamminedichloroplatinum(II): N7(dG)-to-N7(dG) Cross-Linking at 5'-d(GC) in Synthetic Oligonucleotides., H. Huang, J. Woo, S. C. Alley and P. B. Hopkins, Bioorg. Med. Chem., 3 659 (1995). (invited contribution)


FR66979 Requires Reductive Activation to Cross-Link DNA Efficiently., H. Huang, S. R. Rajski, R. M. Williams, and P. B. Hopkins, Tetrahedron Lett., 35 9669 (1995).


Monitoring DNA Dynamics Using Spin-Labels With Different Independent Mobilities., E. J. Hustedt, J. J. Kirchner, A. Spaltenstein, P. B. Hopkins and B. H. Robinson, Biochemistry, 34 4369 (1995).


A Mechlorethamine-Induced Interstrand Cross-Link Bends Duplex DNA., S. M. Rin, P. B. Hopkins, Biochemistry, 34 1439 (1995).


Back to Research Interest

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Awards & Activities

American Association for the Advancement of Sciences (AAAS) Fellow

Arthur C. Cope Scholar Award

Fellow of the Alfred P. Sloan Foundation

Searle Scholar

National Science Foundation Predoctoral Fellow

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