Dustin Maly

Representative Publications

 

Brigham, J. L.; Perera, B. G. K.; Maly, D. J. “A hexylchloride-based catch-and-release system for chemical proteomic applications.” ACS Chem. Biol. 2013, 8, 691-699.


Andrews, S. S.; Hill, Z. B.; Perera, B. G. K.; Maly, D. J. “Label Transfer Reagents to Probe p38 MAPK Binding Partners.” ChemBioChem 2013, 14, 209-216.


Zhang, Z.; Ojo, K. K.; Johnson, S. M.; Larson, E. T.; He, P.; Geiger, J. A.; Castellanos-Gonzalez, A.; White, C. A.; Parsons, M.; Merritt, E. A.; Maly, D. J.; Verlinde, C. L. M. J.; Van Voorhis, W. C.; Fan, E. “Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.” Bioorg. Med. Chem. Lett. 2012, 22, 5264-5267.

 

Ranjitkar, P.; Perera, B. G. K.; Swaney, D.; Hari, S. B.; Larson, E. T.; Krishnamurty, R.; Merritt, E. A.; Villén, J.; Maly, D. J. “Affinity-Based Probes Based on Type II Kinase Inhibitors.” J. Am. Chem. Soc. 2012, 134, 19017-19025.

 

Johnson, S. M.; Murphy, R. C.; Geiger, J. A.; DeRocher, A. E.; Zhang, Z.; Ojo, K. K.; Larson, E. T.; Perera, B. G. K.; Dale, E. J.; He, P.; Reid, M. C.; Fox, A. M. W.; Mueller, N. R.; Merritt, E. A.; Fan, E.; Parsons, M.; Van Voorhis, W. C.; Maly, D. J. “Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity.” J. Med. Chem. 2012, 55, 2416-2426.

 

Ojo, K. K.; Pfander, C.; Mueller, N. R.; Burstroem, C.; Larson, E. T.; Bryan, C. M.; Fox, A. M. W.; Reid, M. C.; Johnson, S. M.; Murphy, R. C.; Kennedy, M.; Mann, H.; Leibly, D. J.; Hewitt, S. N.; Verlinde, C. M. J.; Kappe, S.; Merritt, E. A.; Maly, D. J.; Billker, O.; Van Voorhis, W. C. “Transmission of malaria to mosquitos blocked by bumped kinase inhibitors.” J. Clin. Invest. 2012, 122, 2301-2305.


Larson, E. T.; Ojo, K. K.; Murphy, R. C.; Johnson, S. M.; Zhang, Z.; Kim, J. E.; Leibly, D. J.; Fox, A. M. W.; Reid, M. C.; Dale, E. J.; Perera, B. G. K.; Kim, J.; Hewitt, S. N.; Hol, W. G. J.; Verlinde, C. M. J.; Fan, E.;  Van Voorhis, W. C.; Maly, D. J.; Merritt, E. A. “Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.” J. Med. Chem. 2012, 55, 2803-2810.


Hill, Z. B.; Perera, B. G. K.; Andrews, S.; Maly, D. J. “Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors.” ACS Chem. Biol. 2012, 7, 487-495.


Hari, S. B.; Ranjitkar, P.; Maly, D. J. “Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases.” Methods Mol. Biol. 2012, 928, 153-159.


Ranjitkar, P.; Maly, D. J. “Affinity purification of protein kinases that adopt a specific inactive conformation.” Methods Mol. Biol. 2012, 928, 143-151.


Goreshnik, I; Brock, A. M.; Maly, D. J. “Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.” Bioorg. Med. Chem. Lett. 2011, 21, 4951-4955.


Hill, Z. B.; Perera, B. G. K.; Maly, D. J. “Bivalent inhibitors of the tyrosine kinases ABL and SRC: determinants of potency and selectivity.” Mol. BioSyst. 2011, 7, 447-456.


Krishnamurty, R.; Brock, A. M.; Maly, D. J. “Protein kinase affinity reagents based on a 5-aminoIndazoles scaffold.” Bioorg. Med. Chem. Lett. 2011, 21, 550-554.

 

Goreshnik, I.; Maly, D. J. “A Small Molecule-Regulated Guanine Nucleotide Exchange Factor.” J. Am. Chem. Soc. 2010, 132, 938-940.


Murphy, R. C.; Ojo, K. K.; Larson, E. T.; Castellanos-Gonzalez, A.; Perera, B. G. K.; Keyloun, K. R.; Kim, J. E.; Bhandari, J. G.; Muller, N. R.; Verlinde, C. L. M. J.; White, C. A.; Merritt, E. A.; Van Voorhis, W. C.; Maly, D. J. “Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.” ACS Med. Chem. Lett. 2010, 1, 331-335.


Ojo, K. K.; Larson, E. T.; Keyloun, K. R.; Castaneda, L. J.; DeRocher, A. E.; Inampudi, K. K.; Kim, J. E.; Arakaki, T.; Murphy, R. C.; Zhang, L.; Napuli, A. J.; Maly, D. J.; Verlinde, C. L. M. J.; Buckner, F. S.; Parsons, M.; Hol, W. G. J.; Merritt, E. A.; Van Voorhis W. C. “Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.” Nat. Struct. Mol. Biol. 2010, 17, 602-607.


Gregersen, K. A. D.; Hill, Z. B.; Gadd, J. C.; Fujimoto, B.; Maly, D. J.; Chiu, D. T. “Intracellular Delivery of Bioactive Molecules Using Light-Addressable Nanocapsules.” ACS Nano 2010, 4, 7603-7611.


Krishnamurty, R.; Maly, D. J. “Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors.” ACS Chem. Biol. 2010, 5, 121-138.


Ranjitkar, P.; Brock, A. M.; Maly, D. J. “Affinity Probes that Target a Specific Inactive Conformation of Protein Kinases.” Chem. Biol. 2010, 17, 195-206.


Hill, Z. B.; Perera, B. G. K.; Maly, D. J. “A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases.” J. Am. Chem. Soc. 2009, 131, 6686-6688.


Seeliger, M. A.; Ranjitkar, P.; Kasap. C.; Shan, Y.; Shaw, D. E.; Shah, N. E.; Kuriyan, J.; Maly, D. J. “Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations.” Cancer Res. 2009, 69, 2384-2392.


Blacken, G. R.; Volný, M.; Diener, M.; Jackson, K. E.; Ranjitkar, P.; Maly, D. J.; Tureček, F. “Reactive Landing of Gas-Phase Ions as a Tool for the Fabrication of Metal Oxide Surfaces for In Situ Phosphopeptide Enrichment.” J. Am. Soc. Mass Spectrom. 2009, 20, 915-926.


Perera, G.; Maly, D. J. “Design, Synthesis and Characterization of ‘Clickable’ 4-Anilinoquinazoline Kinase Inhibitors.” Mol. BioSyst. 2008, 4, 542-550.

Back to Research Interests

Back to Research Interests

Awards & Activities

  • Pfizer Fellow of the Life Sciences Research Foundation (University of California at San Francisco, 2003-2006)
  • University of California at Berkeley Outstanding Graduate Student Instructor Award (2001)
  • Hilldale Undergraduate Research Fellowship (1996)

 

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