Pradipsinh K. Rathod

Representative Publications

  • Herricks, T.; Seydel, K.B.; Molyneux, M.; Taylor, T.; Rathod, P.K. "Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients." Cellular Microbiology 2012 (in press). PMID:22892025
  • Marwaha, A.; White, J.; El Mazouni, F.; Creason, S.A.; Kokkonda, S.; Buckner, F.S.; Charman, S.A.; Phillips, M.A.; Rathod, P.K. "Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase." J. Med. Chem. 2012, 55(17), 7425-7436. PMID: 22877245
  • Narayanasamy, K.; Chery, L.; Basu, A.; Duraisingh, M.T.; Escalante, A.; Fowble, J.; Guler, J.L.; Herricks, T.; Kumar, A.; Majumder, P.; Maki, J.; Mascarenhas, A.; Rodrigues, J.; Roy, B.; Sen, S.; Shastri, J.; Smith, J.; Valecha, N.; White, J.; and Rathod, P.K. "Malaria evolution in South Asia: knowledge for control and elimination." Acta Trop. 2012, 121(3), 256-266. PMID: 22266213
  • Kumar, A.; Chery, L.; Biswas, C.; Dubhashi, N.; Dutta, P.; Dua, V.K.; Kacchap, M.; Kakati, S.; Khandeparkar, A.; Kour, D.; Mahajan, S.N.; Maji, A.; Majumder, P.; Mohanta, J.; Mohapatra, P.K.; Narayanasamy, K.; Roy, K.; Shastri, J.; Valecha, N.; Vikash, R.; Wani, R.; White, J.; and Rathod P.K. "Malaria in South Asia: prevalence and control." Acta Trop. 2012, 121(3), 246-255. PMID: 22248528
  • Herricks, T.; Seydel, K.B.; Turner, G.; Molyneux, M.; Heyderman, R.; Taylor, T.; and Rathod, P.K. "A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells." Lab Chip. 2011, 11(17), 2994-3000. PMID: 21743938
  • Kumar, A.; Dua, V.K.; Rathod, P.K. "Malaria-attributed death rates in India." The Lancet 2011, 377(9770), 991-992.
  • Larson, E.T.; Mudeppa, D.G.; et al. “The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.” J. Mol. Biol. 2010, 396(5), 1244-1259.
  • Deng, X.; Gujjar, R.; et al. "Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds." J. Biol. Chem. 2009, 284, 26999-27009.
  • Herricks, T.; Antia, M.; and Rathod, P.K. “Deformability limits of Plasmodium falciparum-infected red blood cells.” Cell Microbiol. 2009, 11, 1340-1353.
  • Gujjar, R.; Marwaha, A.; et al. “Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with anti-malarial activity in mice.” J. Med. Chem. 2009, 52 (7), 1864-1872.
  • Ganesan, K.; Ponmee, N.; Jiang, L.; Fowble, J.W.; White, J.; Kamchonwongpaisan, S.; Yuthavong, Y.; Wilairat, P.; Rathod, P.K. "A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates." PLoS Pathog. 2008, 4(11): e1000214. PMC2581438
  • Gonzales, J.M.; Patel, J.J.; Ponmee, N.; Jiang, L.; Tan, A.; Maher, S.P.; Wuchty, S.; Rathod, P.K.; and Ferdig, M.T. "Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation." PLoS Biol. 2008, 6(9): e238. PMC2581438
  • Antia, M.; Herricks, T.; and Rathod, P.K. “Microfluidic models for Malaria Pathogenesis.” Cell. Microbiol. 2008, 10(10), 1968-1974 (Invited Review). PMID18754851
  • Phillips, M.A.; Gujjar, R.; Malmquist, N.A.; White, J.; El Mazouni, F.; Baldwin, J.; and  Rathod, P.K. “Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite, Plasmodium falciparum. J. Med. Chem. 2008, 51, 3649-3653. PMC2624570
  • Hunter, J.H.; Gujjar, R.; Pang, C.K.T.; and Rathod, P.K. “Kinetics and Ligand-Binding Preferences of Mycobacterium tuberculosis Thymidylate Synthases, ThyA and ThyX.” PLoS One 2008, 3(5): e2237. PMC2386288
  • Antia, M.; Herricks, T.; and Rathod, P.K. “Microfluidic modeling of cell-cell interactions in malaria pathogenesis.” PloS Pathogens 2007, 3:e99. PMC1924869
  • Mudeppa, D.G.; Pang , C.K.T.; Tsuboi, T.; Endo, Y.; Buckner, F.S.; Varani, G.; and Rathod, P.K. "Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.” Mol. Biochem. Parasitol. 2007, 151, 216-219.
  • Shelby, J.P.; White, J.; Ganesan, K.; Rathod, P.K.; and Chiu, D.T. “A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes.” Proc. Natl. Acad. Sci. USA 2003, 100, 14618-14622.
  • Rathod, P.K. and Phillips, M.A. “Prized malaria drug target nailed.” Nature Struct. Biol. 2003, 10, 316-318.
  • Zhang, K. and Rathod, P. K. “Divergent regulation of dihydrofolate reductase between malaria parasite and human host.” Science 2002, 296, 545-547.
  • Rathod, P.K.; Ganesan, K.; Hayward, R.E.; Bozdech, Z.; and DeRisi, J. L. "DNA Microarrays for Malaria." Trends in Parasitology 2002, 18, 39-45.
  • Hayword, R.; DeRisi, J.; Alfadhli, S.; Kaslow, D.; Brown, P.; and Rathod, P.K. “Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria.” Mol. Microbiol. 2000, 35, 6-14.
  • Rathod, P. K.; McErlean, T.; and Lee, P.-C. "Variation in frequency of drug resistance in Plasmodium falciparum." Proc. Natl. Acad. Sci. USA 1997, 94, 9389-9393.
  • Laur, S. A.; Rathod, P. K.; Ghori, N.; and Haldar, K. "A membrane network for nutrient transport in red cells infected with the malaria parasite." Science 1997, 276, 1122-1125.
  • Gomez, Z. M. and Rathod, P. K. "Antimalarial activity of a 5-fluoroorotate and uridine combination in mice." Antimicrob. Agents. Chemother. 1990, 34, 1371-1375.
  • Rathod, P. K.;  Khatri, A.;  Hubbard, T.; and Milhous, W. K. "Selective activity of 5-fluoroorotate against Plasmodium falciparum in vitro." Antimicrob. Agents. Chemother. 1989, 33, 1090-1094.
  • Reyes, P.; Rathod, P. K.; Sanchez, D. J.; Mrema, J. E. K.; Riekman, K. H.; and Heidrich, H.-G. "Activities of purine and pyrimidine metabolizing enzymes of the human malarial parasite, Plasmodium falciparum." Mol. Biochem. Parasitol. 1982, 5, 275-290.

 

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Awards & Activities

Honors

  • Director, NIH International Center of Excellence for Malaria Research in South Asia (South Asia ICEMR) (2010-2017)
  • Grand Challenges Explorations Award, Bill & Melinda Gates Foundation (2009-2012)
  • Co-chair, Molecular Parasitology Meeting, Marine Biological Labs, Woods Hole, MA (2007-2009)
  • Co-chair, Drugs Against Parasitic Diseases Keystone Meeting, Copper Mountain, CO (2005)
  • Senior Scholar Award, Global Infectious Diseases, Ellison Medical Foundation (2002)
  • Molecular, Cellular, and Immunology of Parasites Award, American Society of Tropical Medicine and Hygiene (2002)
  • Module Director, Biology of Parasitism Course, Marine Biological Labs, Woods Hole, MA (2000-2002)
  • New Initiatives in Malaria Research Award, Burroughs Wellcome Fund (1997-2000)
  • Visiting Professor and Lecturer in Biochemistry, Stanford University Medical Center, CA (1995-2002)
  • Tropical Medicine and Parasitology Study Section, NIH (1995-2000)
  • Research Career Development Award, NIAID NIH(1994-1999)
  • First Independent Research Support and Transition (FIRST) AWARD, NIAID NIH (1988-1993)

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